Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon
Lufenuron is a benzoylurea insecticide currently in use to combat sea lice infestation in salmon aquaculture in Chile. With pending approval in Norway, the aim of this work was to study the uptake and toxicity of lufenuron in liver tissue of Atlantic salmon. Juvenile salmon weighing 40 g were given...
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Online Access: | https://hdl.handle.net/11250/3111685 https://doi.org/10.1111/jfd.13880 |
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ftimr:oai:imr.brage.unit.no:11250/3111685 2024-02-11T10:02:07+01:00 Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon Olsvik, Pål Asgeir Brokke, Kristine Ertnæs Samuelsen, Ole Hannisdal, Rita 2023 application/pdf https://hdl.handle.net/11250/3111685 https://doi.org/10.1111/jfd.13880 eng eng Havforskningsinstituttet: 15357 Journal of Fish Diseases. 2023, 1-14. urn:issn:0140-7775 https://hdl.handle.net/11250/3111685 https://doi.org/10.1111/jfd.13880 cristin:2201768 1-14 Journal of Fish Diseases Peer reviewed Journal article 2023 ftimr https://doi.org/10.1111/jfd.13880 2024-01-17T23:47:42Z Lufenuron is a benzoylurea insecticide currently in use to combat sea lice infestation in salmon aquaculture in Chile. With pending approval in Norway, the aim of this work was to study the uptake and toxicity of lufenuron in liver tissue of Atlantic salmon. Juvenile salmon weighing 40 g were given a standard 7-day oral dose, and bioaccumulation and transcriptional responses in the liver were examined 1 day after the end-of-treatment (day 8) and after 1 week of elimination (day 14). Bioaccumulation levels of lufenuron were 29 ± 3 mg/kg at day 8 and 14 ± 1 mg/kg at day 14, indicating relatively rapid clearance. However, residues of lufenuron were still present in the liver after 513 days of depuration. The exposure gave a transient inhibition of transcription in the liver at day 8 (2437 significant DEGs, p-adj < .05), followed by a weaker compensatory response at day 14 (169 significant DEGs). Pathways associated with RNA metabolism such as the sumoylation pathway were most strongly affected at day 8, while the apelin pathway was most profoundly affected at day 14. In conclusion, this study shows that lufenuron easily bioaccumulates and that a standard 7-day oral dose induces a transient inhibition of transcription in liver of salmon. publishedVersion Article in Journal/Newspaper Atlantic salmon Institute for Marine Research: Brage IMR Norway Journal of Fish Diseases 47 2 |
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Open Polar |
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Institute for Marine Research: Brage IMR |
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language |
English |
description |
Lufenuron is a benzoylurea insecticide currently in use to combat sea lice infestation in salmon aquaculture in Chile. With pending approval in Norway, the aim of this work was to study the uptake and toxicity of lufenuron in liver tissue of Atlantic salmon. Juvenile salmon weighing 40 g were given a standard 7-day oral dose, and bioaccumulation and transcriptional responses in the liver were examined 1 day after the end-of-treatment (day 8) and after 1 week of elimination (day 14). Bioaccumulation levels of lufenuron were 29 ± 3 mg/kg at day 8 and 14 ± 1 mg/kg at day 14, indicating relatively rapid clearance. However, residues of lufenuron were still present in the liver after 513 days of depuration. The exposure gave a transient inhibition of transcription in the liver at day 8 (2437 significant DEGs, p-adj < .05), followed by a weaker compensatory response at day 14 (169 significant DEGs). Pathways associated with RNA metabolism such as the sumoylation pathway were most strongly affected at day 8, while the apelin pathway was most profoundly affected at day 14. In conclusion, this study shows that lufenuron easily bioaccumulates and that a standard 7-day oral dose induces a transient inhibition of transcription in liver of salmon. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Olsvik, Pål Asgeir Brokke, Kristine Ertnæs Samuelsen, Ole Hannisdal, Rita |
spellingShingle |
Olsvik, Pål Asgeir Brokke, Kristine Ertnæs Samuelsen, Ole Hannisdal, Rita Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon |
author_facet |
Olsvik, Pål Asgeir Brokke, Kristine Ertnæs Samuelsen, Ole Hannisdal, Rita |
author_sort |
Olsvik, Pål Asgeir |
title |
Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon |
title_short |
Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon |
title_full |
Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon |
title_fullStr |
Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon |
title_full_unstemmed |
Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon |
title_sort |
lufenuron treatment temporarily represses gene expression and affects the sumo pathway in liver of atlantic salmon |
publishDate |
2023 |
url |
https://hdl.handle.net/11250/3111685 https://doi.org/10.1111/jfd.13880 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
1-14 Journal of Fish Diseases |
op_relation |
Havforskningsinstituttet: 15357 Journal of Fish Diseases. 2023, 1-14. urn:issn:0140-7775 https://hdl.handle.net/11250/3111685 https://doi.org/10.1111/jfd.13880 cristin:2201768 |
op_doi |
https://doi.org/10.1111/jfd.13880 |
container_title |
Journal of Fish Diseases |
container_volume |
47 |
container_issue |
2 |
_version_ |
1790598019595370496 |