Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon
Methionine is an indispensable amino acid with an important role as the main methyl donor in cellular metabolism for both fish and mammals. Metabolization of methionine to the methyl donor S-adenosylmethionine (SAM) has consequence for polyamine, carnitine, phospholipid, and creatine synthesis as we...
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ftimr:oai:imr.brage.unit.no:11250/3106812 2024-01-07T09:42:13+01:00 Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon Espe, Marit Adam, Anne-Catrin Saito, Takaya Skjærven, Kaja Helvik 2023 application/pdf https://hdl.handle.net/11250/3106812 https://doi.org/10.1155/2023/5706177 eng eng Havforskningsinstituttet: 15469 Aquaculture Nutrition. 2023, 2023 . urn:issn:1353-5773 https://hdl.handle.net/11250/3106812 https://doi.org/10.1155/2023/5706177 cristin:2208991 10 2023 Aquaculture Nutrition Peer reviewed Journal article 2023 ftimr https://doi.org/10.1155/2023/5706177 2023-12-13T23:47:43Z Methionine is an indispensable amino acid with an important role as the main methyl donor in cellular metabolism for both fish and mammals. Metabolization of methionine to the methyl donor S-adenosylmethionine (SAM) has consequence for polyamine, carnitine, phospholipid, and creatine synthesis as well as epigenetic modifications such as DNA- and histone tail methylation. Methionine can also be converted to cysteine and contributes as a precursor for taurine and glutathione synthesis. Moreover, methionine is the start codon for every protein being synthetized and thereby serves an important role in initiating translation. Modern salmon feed is dominated by plant ingredients containing less taurine, carnitine, and creatine than animal-based ingredients. This shift results in competition for SAM due to an increasing need to endogenously synthesize associated metabolites. The availability of methionine has profound implications for various metabolic pathways including allosteric regulation. This necessitates a higher nutritional need to meet the requirement as a methyl donor, surpassing the quantities for protein synthesis and growth. This comprehensive review provides an overview of the key metabolic pathways in which methionine plays a central role as methyl donor and unfolds the implications for methylation capacity, metabolism, and overall health particularly emphasizing the development of fatty liver, oxidation, and inflammation when methionine abundance is insufficient focusing on nutrition for Atlantic salmon (Salmo salar). publishedVersion Article in Journal/Newspaper Atlantic salmon Salmo salar Institute for Marine Research: Brage IMR Aquaculture Nutrition 2023 1 10 |
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Institute for Marine Research: Brage IMR |
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English |
description |
Methionine is an indispensable amino acid with an important role as the main methyl donor in cellular metabolism for both fish and mammals. Metabolization of methionine to the methyl donor S-adenosylmethionine (SAM) has consequence for polyamine, carnitine, phospholipid, and creatine synthesis as well as epigenetic modifications such as DNA- and histone tail methylation. Methionine can also be converted to cysteine and contributes as a precursor for taurine and glutathione synthesis. Moreover, methionine is the start codon for every protein being synthetized and thereby serves an important role in initiating translation. Modern salmon feed is dominated by plant ingredients containing less taurine, carnitine, and creatine than animal-based ingredients. This shift results in competition for SAM due to an increasing need to endogenously synthesize associated metabolites. The availability of methionine has profound implications for various metabolic pathways including allosteric regulation. This necessitates a higher nutritional need to meet the requirement as a methyl donor, surpassing the quantities for protein synthesis and growth. This comprehensive review provides an overview of the key metabolic pathways in which methionine plays a central role as methyl donor and unfolds the implications for methylation capacity, metabolism, and overall health particularly emphasizing the development of fatty liver, oxidation, and inflammation when methionine abundance is insufficient focusing on nutrition for Atlantic salmon (Salmo salar). publishedVersion |
format |
Article in Journal/Newspaper |
author |
Espe, Marit Adam, Anne-Catrin Saito, Takaya Skjærven, Kaja Helvik |
spellingShingle |
Espe, Marit Adam, Anne-Catrin Saito, Takaya Skjærven, Kaja Helvik Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon |
author_facet |
Espe, Marit Adam, Anne-Catrin Saito, Takaya Skjærven, Kaja Helvik |
author_sort |
Espe, Marit |
title |
Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon |
title_short |
Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon |
title_full |
Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon |
title_fullStr |
Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon |
title_full_unstemmed |
Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon |
title_sort |
methionine: an indispensable amino acid in cellular metabolism and health of atlantic salmon |
publishDate |
2023 |
url |
https://hdl.handle.net/11250/3106812 https://doi.org/10.1155/2023/5706177 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
10 2023 Aquaculture Nutrition |
op_relation |
Havforskningsinstituttet: 15469 Aquaculture Nutrition. 2023, 2023 . urn:issn:1353-5773 https://hdl.handle.net/11250/3106812 https://doi.org/10.1155/2023/5706177 cristin:2208991 |
op_doi |
https://doi.org/10.1155/2023/5706177 |
container_title |
Aquaculture Nutrition |
container_volume |
2023 |
container_start_page |
1 |
op_container_end_page |
10 |
_version_ |
1787423155172671488 |