Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua)
In the North Sea and North Atlantic coastal areas, fish experience relatively high background levels of persistent organic pollutants. This study aimed to compare the mode of action of environmentally relevant concentrations of mixtures of halogenated compounds in Atlantic cod. Juvenile male cod wit...
Published in: | Journal of Applied Toxicology |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2023
|
Subjects: | |
Online Access: | https://hdl.handle.net/11250/3104372 https://doi.org/10.1002/jat.4519 |
id |
ftimr:oai:imr.brage.unit.no:11250/3104372 |
---|---|
record_format |
openpolar |
spelling |
ftimr:oai:imr.brage.unit.no:11250/3104372 2023-12-24T10:14:53+01:00 Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) Olsvik, Pål Asgeir Meier, Sonnich Zhang, Xiaokang Goksøyr, Anders Karlsen, Odd André Yadetie, Fekadu 2023 application/pdf https://hdl.handle.net/11250/3104372 https://doi.org/10.1002/jat.4519 eng eng Norges forskningsråd: 245979 Norges forskningsråd: 184641 Norges forskningsråd: 248840 Journal of Applied Toxicology. 2023, 43 (12), 1859-1871. urn:issn:0260-437X https://hdl.handle.net/11250/3104372 https://doi.org/10.1002/jat.4519 cristin:2175001 1859-1871 43 Journal of Applied Toxicology 12 Peer reviewed Journal article 2023 ftimr https://doi.org/10.1002/jat.4519 2023-11-29T23:47:44Z In the North Sea and North Atlantic coastal areas, fish experience relatively high background levels of persistent organic pollutants. This study aimed to compare the mode of action of environmentally relevant concentrations of mixtures of halogenated compounds in Atlantic cod. Juvenile male cod with mean weight of 840 g were exposed by gavage to dietary mixtures of chlorinated (PCBs, DDT analogs, chlordane, lindane, and toxaphene), brominated (PBDEs), and fluorinated (PFOS) compounds for 4 weeks. One group received a combined mixture of all three compound groups. The results showed that the accumulated levels of chemicals in cod liver after 4 weeks of exposure reflected concentrations found in wild fish in this region. Pathway analysis revealed that the treatment effects by each of the three groups of chemicals (chlorinated, brominated, and fluorinated) converged on activation of the unfolded protein response (UPR). Upstream regulator analysis predicted that almost all the key transcription factors (XBP1, ERN1, ATF4, EIF2AK3, and NFE2L2) regulating the UPR were significantly activated. No additive effect was observed in cod co-treated with all three compound groups. In conclusion, the genome-wide transcriptomic study suggests that the UPR pathway is a sensitive common target of halogenated organic environmental pollutants in fish. publishedVersion Article in Journal/Newspaper atlantic cod Gadus morhua North Atlantic Institute for Marine Research: Brage IMR Journal of Applied Toxicology 43 12 1859 1871 |
institution |
Open Polar |
collection |
Institute for Marine Research: Brage IMR |
op_collection_id |
ftimr |
language |
English |
description |
In the North Sea and North Atlantic coastal areas, fish experience relatively high background levels of persistent organic pollutants. This study aimed to compare the mode of action of environmentally relevant concentrations of mixtures of halogenated compounds in Atlantic cod. Juvenile male cod with mean weight of 840 g were exposed by gavage to dietary mixtures of chlorinated (PCBs, DDT analogs, chlordane, lindane, and toxaphene), brominated (PBDEs), and fluorinated (PFOS) compounds for 4 weeks. One group received a combined mixture of all three compound groups. The results showed that the accumulated levels of chemicals in cod liver after 4 weeks of exposure reflected concentrations found in wild fish in this region. Pathway analysis revealed that the treatment effects by each of the three groups of chemicals (chlorinated, brominated, and fluorinated) converged on activation of the unfolded protein response (UPR). Upstream regulator analysis predicted that almost all the key transcription factors (XBP1, ERN1, ATF4, EIF2AK3, and NFE2L2) regulating the UPR were significantly activated. No additive effect was observed in cod co-treated with all three compound groups. In conclusion, the genome-wide transcriptomic study suggests that the UPR pathway is a sensitive common target of halogenated organic environmental pollutants in fish. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Olsvik, Pål Asgeir Meier, Sonnich Zhang, Xiaokang Goksøyr, Anders Karlsen, Odd André Yadetie, Fekadu |
spellingShingle |
Olsvik, Pål Asgeir Meier, Sonnich Zhang, Xiaokang Goksøyr, Anders Karlsen, Odd André Yadetie, Fekadu Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
author_facet |
Olsvik, Pål Asgeir Meier, Sonnich Zhang, Xiaokang Goksøyr, Anders Karlsen, Odd André Yadetie, Fekadu |
author_sort |
Olsvik, Pål Asgeir |
title |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_short |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_full |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_fullStr |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_full_unstemmed |
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua) |
title_sort |
environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of atlantic cod (gadus morhua) |
publishDate |
2023 |
url |
https://hdl.handle.net/11250/3104372 https://doi.org/10.1002/jat.4519 |
genre |
atlantic cod Gadus morhua North Atlantic |
genre_facet |
atlantic cod Gadus morhua North Atlantic |
op_source |
1859-1871 43 Journal of Applied Toxicology 12 |
op_relation |
Norges forskningsråd: 245979 Norges forskningsråd: 184641 Norges forskningsråd: 248840 Journal of Applied Toxicology. 2023, 43 (12), 1859-1871. urn:issn:0260-437X https://hdl.handle.net/11250/3104372 https://doi.org/10.1002/jat.4519 cristin:2175001 |
op_doi |
https://doi.org/10.1002/jat.4519 |
container_title |
Journal of Applied Toxicology |
container_volume |
43 |
container_issue |
12 |
container_start_page |
1859 |
op_container_end_page |
1871 |
_version_ |
1786199465466527744 |