Micronutrient supplementation affects DNA methylation in male gonads with potential intergenerational epigenetic inheritance involving the embryonic development through glutamate receptor-associated genes

DNA methylation has an important role in intergenerational inheritance. An increasing number of studies have reported evidence of germline inheritance of DNA methylation induced by nutritional signals in mammals. Vitamins and minerals as micronutrients contribute to growth performance in vertebrates...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: Saito, Takaya, Whatmore, Paul, Taylor, John F., Fernandes, Jorge Manuel de Oliveira, Adam, Anne-Catrin, Tocher, Douglas R., Espe, Marit, Skjærven, Kaja Helvik
Format: Article in Journal/Newspaper
Language:English
Published: 2022
Subjects:
Atlantic salmon
Salmo salar
Online Access:https://hdl.handle.net/11250/3014630
https://doi.org/10.1186/s12864-022-08348-4
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Summary:DNA methylation has an important role in intergenerational inheritance. An increasing number of studies have reported evidence of germline inheritance of DNA methylation induced by nutritional signals in mammals. Vitamins and minerals as micronutrients contribute to growth performance in vertebrates, including Atlantic salmon (Salmo salar), and also have a role in epigenetics as environmental factors that alter DNA methylation status. It is important to understand whether micronutrients in the paternal diet can influence the offspring through alterations of DNA methylation signatures in male germ cells. publishedVersion

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