Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon?
The substitution of fish oil and fishmeal with plant-based ingredients in commercial aquafeeds for Atlantic salmon, may introduce novel contaminants that have not previously been associated with farmed fish. The organophosphate pesticide pirimiphos-methyl (PM) is one of the novel contaminants that i...
Published in: | Food Additives & Contaminants: Part A |
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Language: | English |
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Online Access: | https://hdl.handle.net/11250/2719125 https://doi.org/10.1080/19440049.2020.1829717 |
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ftimr:oai:imr.brage.unit.no:11250/2719125 2023-05-15T15:29:45+02:00 Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? Berntssen, Marc HG Hoogenveen, Rudolf Rosenlund, Grethe Garlito, Borja Zeilmaker, Marco J. 2020 application/pdf https://hdl.handle.net/11250/2719125 https://doi.org/10.1080/19440049.2020.1829717 eng eng Food Additives & Contaminants. 2020, . urn:issn:1944-0049 https://hdl.handle.net/11250/2719125 https://doi.org/10.1080/19440049.2020.1829717 cristin:1855993 0 Food Additives & Contaminants Peer reviewed Journal article 2020 ftimr https://doi.org/10.1080/19440049.2020.1829717 2021-09-23T20:15:02Z The substitution of fish oil and fishmeal with plant-based ingredients in commercial aquafeeds for Atlantic salmon, may introduce novel contaminants that have not previously been associated with farmed fish. The organophosphate pesticide pirimiphos-methyl (PM) is one of the novel contaminants that is most prevalent in commercial salmon feed. In this study, the feed-to-fillet transfer of dietary PM and its main metabolites was investigated in Atlantic salmon fillet. Based on the experimental determined PM and metabolite uptake, metabolisation, and elimination kinetics, a physiologically based toxicokinetic (PBTK) compartmental model was developed. Fish fed PM had a relatively low (~4%) PM retention and two main metabolites (2-DAMP and Desethyl-PM) were identified in liver, muscle, kidney and bile. The absence of more metabolised forms of 2-DAMP and Desethyl-PM in Atlantic salmon indicates different metabolism in cold-water fish compared to previous studies on ruminants. The model was used to simulate the long term (>1.5 years) feed-to-fillet transfer of PM + metabolite in Atlantic salmon under realistic farming conditions including seasonal fluctuations in feed intake, growth, and fat deposition in muscle tissue. The model predictions show that with the constant presence of the highest observed PM concentration in commercial salmon feed, fillet PM+ metabolite levels were approximately 5 nmol kg−1, with highest levels for the metabolite 2-DAMP. No EU maximum residue levels (MRL) for PM and its main metabolites exist in seafood to date, but the predicted levels were lower than the MRL for PM in swine of 32.7 nmol kg−1. publishedVersion Article in Journal/Newspaper Atlantic salmon Institute for Marine Research: Brage IMR Food Additives & Contaminants: Part A 37 12 2109 2122 |
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Open Polar |
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Institute for Marine Research: Brage IMR |
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language |
English |
description |
The substitution of fish oil and fishmeal with plant-based ingredients in commercial aquafeeds for Atlantic salmon, may introduce novel contaminants that have not previously been associated with farmed fish. The organophosphate pesticide pirimiphos-methyl (PM) is one of the novel contaminants that is most prevalent in commercial salmon feed. In this study, the feed-to-fillet transfer of dietary PM and its main metabolites was investigated in Atlantic salmon fillet. Based on the experimental determined PM and metabolite uptake, metabolisation, and elimination kinetics, a physiologically based toxicokinetic (PBTK) compartmental model was developed. Fish fed PM had a relatively low (~4%) PM retention and two main metabolites (2-DAMP and Desethyl-PM) were identified in liver, muscle, kidney and bile. The absence of more metabolised forms of 2-DAMP and Desethyl-PM in Atlantic salmon indicates different metabolism in cold-water fish compared to previous studies on ruminants. The model was used to simulate the long term (>1.5 years) feed-to-fillet transfer of PM + metabolite in Atlantic salmon under realistic farming conditions including seasonal fluctuations in feed intake, growth, and fat deposition in muscle tissue. The model predictions show that with the constant presence of the highest observed PM concentration in commercial salmon feed, fillet PM+ metabolite levels were approximately 5 nmol kg−1, with highest levels for the metabolite 2-DAMP. No EU maximum residue levels (MRL) for PM and its main metabolites exist in seafood to date, but the predicted levels were lower than the MRL for PM in swine of 32.7 nmol kg−1. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Berntssen, Marc HG Hoogenveen, Rudolf Rosenlund, Grethe Garlito, Borja Zeilmaker, Marco J. |
spellingShingle |
Berntssen, Marc HG Hoogenveen, Rudolf Rosenlund, Grethe Garlito, Borja Zeilmaker, Marco J. Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
author_facet |
Berntssen, Marc HG Hoogenveen, Rudolf Rosenlund, Grethe Garlito, Borja Zeilmaker, Marco J. |
author_sort |
Berntssen, Marc HG |
title |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_short |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_full |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_fullStr |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_full_unstemmed |
Do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed Atlantic salmon? |
title_sort |
do background levels of the pesticide pirimiphosmethyl in plant-based aquafeeds affect food safety of farmed atlantic salmon? |
publishDate |
2020 |
url |
https://hdl.handle.net/11250/2719125 https://doi.org/10.1080/19440049.2020.1829717 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
0 Food Additives & Contaminants |
op_relation |
Food Additives & Contaminants. 2020, . urn:issn:1944-0049 https://hdl.handle.net/11250/2719125 https://doi.org/10.1080/19440049.2020.1829717 cristin:1855993 |
op_doi |
https://doi.org/10.1080/19440049.2020.1829717 |
container_title |
Food Additives & Contaminants: Part A |
container_volume |
37 |
container_issue |
12 |
container_start_page |
2109 |
op_container_end_page |
2122 |
_version_ |
1766360183752097792 |