Vaccination with ectoparasite proteins involved in midgut function and blood digestion reduces salmon louse infestations
Infestation with the salmon louse Lepeophtheirus salmonis (Copepoda, Caligidae) affects Atlantic salmon (Salmo salar L.) production in European aquaculture. Furthermore, high levels of salmon lice in farms significantly increase challenge pressure against wild salmon populations. Currently, availabl...
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Online Access: | https://hdl.handle.net/11250/2686807 https://doi.org/10.3390/vaccines8010032 |
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ftimr:oai:imr.brage.unit.no:11250/2686807 2023-05-15T15:31:09+02:00 Vaccination with ectoparasite proteins involved in midgut function and blood digestion reduces salmon louse infestations Contreras, Marinela Karlsen, Marius Villar, Margarita Olsen, Rolf Hetlelid Leknes, Lisa Marie Furevik, Anette Yttredal, Karine Lindmo Tartor, Haitham Grove, Søren Alberdi, Pilar Brudeseth, Bjørn de la Fuente, José 2020 application/pdf https://hdl.handle.net/11250/2686807 https://doi.org/10.3390/vaccines8010032 eng eng Vaccines. 2020, 8 (1), 1-17. urn:issn:2076-393X https://hdl.handle.net/11250/2686807 https://doi.org/10.3390/vaccines8010032 cristin:1838292 1-17 8 Vaccines 1 Peer reviewed Journal article 2020 ftimr https://doi.org/10.3390/vaccines8010032 2021-09-23T20:16:03Z Infestation with the salmon louse Lepeophtheirus salmonis (Copepoda, Caligidae) affects Atlantic salmon (Salmo salar L.) production in European aquaculture. Furthermore, high levels of salmon lice in farms significantly increase challenge pressure against wild salmon populations. Currently, available control methods for salmon louse have limitations, and vaccination appears as an attractive, environmentally sound strategy. In this study, we addressed one of the main limitations for vaccine development, the identification of candidate protective antigens. Based on recent advances in tick vaccine research, herein, we targeted the salmon louse midgut function and blood digestion for the identification of candidate target proteins for the control of ectoparasite infestations. The results of this translational approach resulted in the identification and subsequent evaluation of the new candidate protective antigens, putative Toll-like receptor 6 (P30), and potassium chloride, and amino acid transporter (P33). Vaccination with these antigens provided protection in Atlantic salmon by reducing adult female (P33) or chalimus II (P30) sea lice infestations. These results support the development of vaccines for the control of sea lice infestations publishedVersion Article in Journal/Newspaper Atlantic salmon Salmo salar Institute for Marine Research: Brage IMR Vaccines 8 1 32 |
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Institute for Marine Research: Brage IMR |
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English |
description |
Infestation with the salmon louse Lepeophtheirus salmonis (Copepoda, Caligidae) affects Atlantic salmon (Salmo salar L.) production in European aquaculture. Furthermore, high levels of salmon lice in farms significantly increase challenge pressure against wild salmon populations. Currently, available control methods for salmon louse have limitations, and vaccination appears as an attractive, environmentally sound strategy. In this study, we addressed one of the main limitations for vaccine development, the identification of candidate protective antigens. Based on recent advances in tick vaccine research, herein, we targeted the salmon louse midgut function and blood digestion for the identification of candidate target proteins for the control of ectoparasite infestations. The results of this translational approach resulted in the identification and subsequent evaluation of the new candidate protective antigens, putative Toll-like receptor 6 (P30), and potassium chloride, and amino acid transporter (P33). Vaccination with these antigens provided protection in Atlantic salmon by reducing adult female (P33) or chalimus II (P30) sea lice infestations. These results support the development of vaccines for the control of sea lice infestations publishedVersion |
format |
Article in Journal/Newspaper |
author |
Contreras, Marinela Karlsen, Marius Villar, Margarita Olsen, Rolf Hetlelid Leknes, Lisa Marie Furevik, Anette Yttredal, Karine Lindmo Tartor, Haitham Grove, Søren Alberdi, Pilar Brudeseth, Bjørn de la Fuente, José |
spellingShingle |
Contreras, Marinela Karlsen, Marius Villar, Margarita Olsen, Rolf Hetlelid Leknes, Lisa Marie Furevik, Anette Yttredal, Karine Lindmo Tartor, Haitham Grove, Søren Alberdi, Pilar Brudeseth, Bjørn de la Fuente, José Vaccination with ectoparasite proteins involved in midgut function and blood digestion reduces salmon louse infestations |
author_facet |
Contreras, Marinela Karlsen, Marius Villar, Margarita Olsen, Rolf Hetlelid Leknes, Lisa Marie Furevik, Anette Yttredal, Karine Lindmo Tartor, Haitham Grove, Søren Alberdi, Pilar Brudeseth, Bjørn de la Fuente, José |
author_sort |
Contreras, Marinela |
title |
Vaccination with ectoparasite proteins involved in midgut function and blood digestion reduces salmon louse infestations |
title_short |
Vaccination with ectoparasite proteins involved in midgut function and blood digestion reduces salmon louse infestations |
title_full |
Vaccination with ectoparasite proteins involved in midgut function and blood digestion reduces salmon louse infestations |
title_fullStr |
Vaccination with ectoparasite proteins involved in midgut function and blood digestion reduces salmon louse infestations |
title_full_unstemmed |
Vaccination with ectoparasite proteins involved in midgut function and blood digestion reduces salmon louse infestations |
title_sort |
vaccination with ectoparasite proteins involved in midgut function and blood digestion reduces salmon louse infestations |
publishDate |
2020 |
url |
https://hdl.handle.net/11250/2686807 https://doi.org/10.3390/vaccines8010032 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
1-17 8 Vaccines 1 |
op_relation |
Vaccines. 2020, 8 (1), 1-17. urn:issn:2076-393X https://hdl.handle.net/11250/2686807 https://doi.org/10.3390/vaccines8010032 cristin:1838292 |
op_doi |
https://doi.org/10.3390/vaccines8010032 |
container_title |
Vaccines |
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8 |
container_issue |
1 |
container_start_page |
32 |
_version_ |
1766361639233257472 |