Effects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar)
Post-smolt Atlantic salmon (Salmo salar) were fed with standard feed added one of five concentrations of either pure deoxynivalenol (DON; 0.5–6 mg/kg) or pure ochratoxin A (OTA; 0.2–2.4 mg/kg), or no added toxins for up to 8 weeks. Performance effects (feed intake, feed efficiency, gain, length and...
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Online Access: | http://hdl.handle.net/11250/2569538 https://doi.org/10.1016/j.fct.2018.08.079 |
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ftimr:oai:imr.brage.unit.no:11250/2569538 2023-05-15T15:31:23+02:00 Effects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar) Bernhoft, Aksel Høgåsen, Helga Rachel Rosenlund, Grethe Moldal, Torfinn Grove, Søren Berntssen, Marc Thoresen, Stein Istre Alexander, Jan 2018 application/pdf http://hdl.handle.net/11250/2569538 https://doi.org/10.1016/j.fct.2018.08.079 eng eng Norges forskningsråd: 199626 Food and Chemical Toxicology. 2018, 121 374-386. urn:issn:0278-6915 http://hdl.handle.net/11250/2569538 https://doi.org/10.1016/j.fct.2018.08.079 cristin:1620215 374-386 121 Food and Chemical Toxicology Journal article Peer reviewed 2018 ftimr https://doi.org/10.1016/j.fct.2018.08.079 2021-09-23T20:14:43Z Post-smolt Atlantic salmon (Salmo salar) were fed with standard feed added one of five concentrations of either pure deoxynivalenol (DON; 0.5–6 mg/kg) or pure ochratoxin A (OTA; 0.2–2.4 mg/kg), or no added toxins for up to 8 weeks. Performance effects (feed intake, feed efficiency, gain, length and condition factor), various clinical biochemical parameters, packed cell volume and vaccination response against Aeromonas salmonicidae were all inversely correlated with DON dose, whereas relative liver weight increased with DON dose. In fish fed OTA, however, the effects at the doses tested were rather small. We observed no effects of OTA exposure on performance parameters, but some clinical biochemical parameters tended to increase with OTA dose primarily at 3 weeks, and compared with controls OTA exposure caused increased mRNA expression of two immune markers in the spleen. No liver histopathological effects were found from DON or OTA exposure. For DON, we derived a BMDL20 of 0.3 mg/kg feed for reduced total protein in plasma, a BMDL5 of 0.5 mg/kg feed for reduced condition factor, and a NOAEL of 1 mg/kg feed for DON. For OTA, a BMDL or NOAEL could not be derived (>2.4 mg/kg). publishedVersion Article in Journal/Newspaper Atlantic salmon Salmo salar Institute for Marine Research: Brage IMR Food and Chemical Toxicology 121 374 386 |
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Open Polar |
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Institute for Marine Research: Brage IMR |
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ftimr |
language |
English |
description |
Post-smolt Atlantic salmon (Salmo salar) were fed with standard feed added one of five concentrations of either pure deoxynivalenol (DON; 0.5–6 mg/kg) or pure ochratoxin A (OTA; 0.2–2.4 mg/kg), or no added toxins for up to 8 weeks. Performance effects (feed intake, feed efficiency, gain, length and condition factor), various clinical biochemical parameters, packed cell volume and vaccination response against Aeromonas salmonicidae were all inversely correlated with DON dose, whereas relative liver weight increased with DON dose. In fish fed OTA, however, the effects at the doses tested were rather small. We observed no effects of OTA exposure on performance parameters, but some clinical biochemical parameters tended to increase with OTA dose primarily at 3 weeks, and compared with controls OTA exposure caused increased mRNA expression of two immune markers in the spleen. No liver histopathological effects were found from DON or OTA exposure. For DON, we derived a BMDL20 of 0.3 mg/kg feed for reduced total protein in plasma, a BMDL5 of 0.5 mg/kg feed for reduced condition factor, and a NOAEL of 1 mg/kg feed for DON. For OTA, a BMDL or NOAEL could not be derived (>2.4 mg/kg). publishedVersion |
format |
Article in Journal/Newspaper |
author |
Bernhoft, Aksel Høgåsen, Helga Rachel Rosenlund, Grethe Moldal, Torfinn Grove, Søren Berntssen, Marc Thoresen, Stein Istre Alexander, Jan |
spellingShingle |
Bernhoft, Aksel Høgåsen, Helga Rachel Rosenlund, Grethe Moldal, Torfinn Grove, Søren Berntssen, Marc Thoresen, Stein Istre Alexander, Jan Effects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar) |
author_facet |
Bernhoft, Aksel Høgåsen, Helga Rachel Rosenlund, Grethe Moldal, Torfinn Grove, Søren Berntssen, Marc Thoresen, Stein Istre Alexander, Jan |
author_sort |
Bernhoft, Aksel |
title |
Effects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar) |
title_short |
Effects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar) |
title_full |
Effects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar) |
title_fullStr |
Effects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar) |
title_full_unstemmed |
Effects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar) |
title_sort |
effects of dietary deoxynivalenol or ochratoxin a on performance and selected health indices in atlantic salmon (salmo salar) |
publishDate |
2018 |
url |
http://hdl.handle.net/11250/2569538 https://doi.org/10.1016/j.fct.2018.08.079 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
374-386 121 Food and Chemical Toxicology |
op_relation |
Norges forskningsråd: 199626 Food and Chemical Toxicology. 2018, 121 374-386. urn:issn:0278-6915 http://hdl.handle.net/11250/2569538 https://doi.org/10.1016/j.fct.2018.08.079 cristin:1620215 |
op_doi |
https://doi.org/10.1016/j.fct.2018.08.079 |
container_title |
Food and Chemical Toxicology |
container_volume |
121 |
container_start_page |
374 |
op_container_end_page |
386 |
_version_ |
1766361884974383104 |