Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean
Brominated flame-retardants (BFRs) such as polybrominated diphenyl ethers (PBDE) and hexabromocyclododecane (HBCD) are considered hazardous to human health. Due to their persistence, they are still present in the environment and in biota and seafood is major contributor of BFRs to human exposure. He...
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Online Access: | http://hdl.handle.net/11250/2561682 https://doi.org/10.1016/j.envint.2018.04.044 |
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ftimr:oai:imr.brage.unit.no:11250/2561682 2023-05-15T15:27:48+02:00 Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean Nøstbakken, Ole Jakob Duinker, Arne Rasinger, Josef Daniel Nilsen, Bente Merete Sanden, Monica Frantzen, Sylvia Hove, Helge Torbjørn Lundebye, Anne-Katrine Berntssen, Marc Hannisdal, Rita Madsen, Lise Måge, Amund 2018 application/pdf http://hdl.handle.net/11250/2561682 https://doi.org/10.1016/j.envint.2018.04.044 eng eng Fiskeri- og havbruksnæringens forskningsfond: 900112 Fiskeri- og havbruksnæringens forskningsfond: 232104 Fiskeri- og havbruksnæringens forskningsfond: 232094 Environment International. 2018, 119 544-557. urn:issn:0160-4120 http://hdl.handle.net/11250/2561682 https://doi.org/10.1016/j.envint.2018.04.044 cristin:1605937 544-557 119 Environment International Journal article Peer reviewed 2018 ftimr https://doi.org/10.1016/j.envint.2018.04.044 2021-09-23T20:14:49Z Brominated flame-retardants (BFRs) such as polybrominated diphenyl ethers (PBDE) and hexabromocyclododecane (HBCD) are considered hazardous to human health. Due to their persistence, they are still present in the environment and in biota and seafood is major contributor of BFRs to human exposure. Here, we used data from >9700 samples of wild and farmed fish, fish feed and fish feed ingredients collected from the North Atlantic between 2006 and 2016 aiming to investigate factors influencing the risk assessments of BFRs. Due to most representative number of analyses, PBDEs were the main focus of investigation. Mean ∑PBDE in fillet samples ranged from below quantification in Atlantic cod fillet to 2.0 μg kg−1 in Atlantic halibut. The main congener contributing to the ∑PBDE in all species was BDE 47. Factors affecting the level of BFR in seafood were multifaceted, and the levels were within species mainly determined by fish age, geographical origin and time of sampling. BDE 47, 99, 153 and HBCD were selected for margin of exposure (MOE) evaluation. When other sources of BFR than seafood were excluded, our risk assessment showed low risk at the current dietary intake of seafood. However, the dietary intake of BDE 99 may be of concern for toddlers when all sources are considered. The choice of fish species, dietary studies, choice of statistics, as well as exposure from other sources than seafood, were all factors that influenced the final MOE of BFRs. We propose the use of regression on order statistics as a tool for risk assessment, to illustrate means and spreads in large surveillance datasets to avoid the issue of measurements below the limit of quantification. A harmonized, updated evaluation of the risk associated with exposure to BFRs from diet, air and dust is warranted, where the fish species most commonly consumed also is taken into consideration. publishedVersion Article in Journal/Newspaper atlantic cod North Atlantic North East Atlantic Institute for Marine Research: Brage IMR Moe ENVELOPE(-45.683,-45.683,-60.733,-60.733) Environment International 119 544 557 |
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Open Polar |
collection |
Institute for Marine Research: Brage IMR |
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ftimr |
language |
English |
description |
Brominated flame-retardants (BFRs) such as polybrominated diphenyl ethers (PBDE) and hexabromocyclododecane (HBCD) are considered hazardous to human health. Due to their persistence, they are still present in the environment and in biota and seafood is major contributor of BFRs to human exposure. Here, we used data from >9700 samples of wild and farmed fish, fish feed and fish feed ingredients collected from the North Atlantic between 2006 and 2016 aiming to investigate factors influencing the risk assessments of BFRs. Due to most representative number of analyses, PBDEs were the main focus of investigation. Mean ∑PBDE in fillet samples ranged from below quantification in Atlantic cod fillet to 2.0 μg kg−1 in Atlantic halibut. The main congener contributing to the ∑PBDE in all species was BDE 47. Factors affecting the level of BFR in seafood were multifaceted, and the levels were within species mainly determined by fish age, geographical origin and time of sampling. BDE 47, 99, 153 and HBCD were selected for margin of exposure (MOE) evaluation. When other sources of BFR than seafood were excluded, our risk assessment showed low risk at the current dietary intake of seafood. However, the dietary intake of BDE 99 may be of concern for toddlers when all sources are considered. The choice of fish species, dietary studies, choice of statistics, as well as exposure from other sources than seafood, were all factors that influenced the final MOE of BFRs. We propose the use of regression on order statistics as a tool for risk assessment, to illustrate means and spreads in large surveillance datasets to avoid the issue of measurements below the limit of quantification. A harmonized, updated evaluation of the risk associated with exposure to BFRs from diet, air and dust is warranted, where the fish species most commonly consumed also is taken into consideration. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Nøstbakken, Ole Jakob Duinker, Arne Rasinger, Josef Daniel Nilsen, Bente Merete Sanden, Monica Frantzen, Sylvia Hove, Helge Torbjørn Lundebye, Anne-Katrine Berntssen, Marc Hannisdal, Rita Madsen, Lise Måge, Amund |
spellingShingle |
Nøstbakken, Ole Jakob Duinker, Arne Rasinger, Josef Daniel Nilsen, Bente Merete Sanden, Monica Frantzen, Sylvia Hove, Helge Torbjørn Lundebye, Anne-Katrine Berntssen, Marc Hannisdal, Rita Madsen, Lise Måge, Amund Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean |
author_facet |
Nøstbakken, Ole Jakob Duinker, Arne Rasinger, Josef Daniel Nilsen, Bente Merete Sanden, Monica Frantzen, Sylvia Hove, Helge Torbjørn Lundebye, Anne-Katrine Berntssen, Marc Hannisdal, Rita Madsen, Lise Måge, Amund |
author_sort |
Nøstbakken, Ole Jakob |
title |
Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean |
title_short |
Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean |
title_full |
Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean |
title_fullStr |
Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean |
title_full_unstemmed |
Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean |
title_sort |
factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the north east atlantic ocean |
publishDate |
2018 |
url |
http://hdl.handle.net/11250/2561682 https://doi.org/10.1016/j.envint.2018.04.044 |
long_lat |
ENVELOPE(-45.683,-45.683,-60.733,-60.733) |
geographic |
Moe |
geographic_facet |
Moe |
genre |
atlantic cod North Atlantic North East Atlantic |
genre_facet |
atlantic cod North Atlantic North East Atlantic |
op_source |
544-557 119 Environment International |
op_relation |
Fiskeri- og havbruksnæringens forskningsfond: 900112 Fiskeri- og havbruksnæringens forskningsfond: 232104 Fiskeri- og havbruksnæringens forskningsfond: 232094 Environment International. 2018, 119 544-557. urn:issn:0160-4120 http://hdl.handle.net/11250/2561682 https://doi.org/10.1016/j.envint.2018.04.044 cristin:1605937 |
op_doi |
https://doi.org/10.1016/j.envint.2018.04.044 |
container_title |
Environment International |
container_volume |
119 |
container_start_page |
544 |
op_container_end_page |
557 |
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1766358203208040448 |