Evolution of the immune system influences speciation rates in teleost fishes
Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic and phenotypic variation, including diverse immune defense strategies. The genomic basis of a particularly aberrant strategy is exemplified by Atlantic cod, in which a loss of major histocompatibility comp...
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Online Access: | http://hdl.handle.net/11250/2484950 https://doi.org/10.1038/ng.3645 |
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ftimr:oai:imr.brage.unit.no:11250/2484950 2023-05-15T15:27:27+02:00 Evolution of the immune system influences speciation rates in teleost fishes Malmstrøm, Martin Matschiner, Michael Tørresen, Ole Kristian Star, Bastiaan Snipen, Lars-Gustav Hansen, Thomas F Baalsrud, Helle Tessand Nederbragt, Alexander Johan Hanel, Reinhold Salzburger, Walter Stenseth, Nils Christian Jakobsen, Kjetill Sigurd Jentoft, Sissel 2016 application/pdf http://hdl.handle.net/11250/2484950 https://doi.org/10.1038/ng.3645 eng eng Norges forskningsråd: 179569 Norges forskningsråd: 222378 Nature Genetics. 2016, 48 (10), 1204-1210. urn:issn:1061-4036 http://hdl.handle.net/11250/2484950 https://doi.org/10.1038/ng.3645 cristin:1392896 1204-1210 48 Nature Genetics 10 Journal article Peer reviewed 2016 ftimr https://doi.org/10.1038/ng.3645 2021-09-23T20:16:03Z Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic and phenotypic variation, including diverse immune defense strategies. The genomic basis of a particularly aberrant strategy is exemplified by Atlantic cod, in which a loss of major histocompatibility complex (MHC) II functionality coincides with a marked expansion of MHC I genes. Through low-coverage genome sequencing (9–39×), assembly and comparative analyses for 66 teleost species, we show here that MHC II is missing in the entire Gadiformes lineage and thus was lost once in their common ancestor. In contrast, we find that MHC I gene expansions have occurred multiple times, both inside and outside this clade. Moreover, we identify an association between high MHC I copy number and elevated speciation rates using trait-dependent diversification models. Our results extend current understanding of the plasticity of the adaptive immune system and suggest an important role for immune-related genes in animal diversification. publishedVersion Article in Journal/Newspaper atlantic cod Institute for Marine Research: Brage IMR Nature Genetics 48 10 1204 1210 |
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Institute for Marine Research: Brage IMR |
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English |
description |
Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic and phenotypic variation, including diverse immune defense strategies. The genomic basis of a particularly aberrant strategy is exemplified by Atlantic cod, in which a loss of major histocompatibility complex (MHC) II functionality coincides with a marked expansion of MHC I genes. Through low-coverage genome sequencing (9–39×), assembly and comparative analyses for 66 teleost species, we show here that MHC II is missing in the entire Gadiformes lineage and thus was lost once in their common ancestor. In contrast, we find that MHC I gene expansions have occurred multiple times, both inside and outside this clade. Moreover, we identify an association between high MHC I copy number and elevated speciation rates using trait-dependent diversification models. Our results extend current understanding of the plasticity of the adaptive immune system and suggest an important role for immune-related genes in animal diversification. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Malmstrøm, Martin Matschiner, Michael Tørresen, Ole Kristian Star, Bastiaan Snipen, Lars-Gustav Hansen, Thomas F Baalsrud, Helle Tessand Nederbragt, Alexander Johan Hanel, Reinhold Salzburger, Walter Stenseth, Nils Christian Jakobsen, Kjetill Sigurd Jentoft, Sissel |
spellingShingle |
Malmstrøm, Martin Matschiner, Michael Tørresen, Ole Kristian Star, Bastiaan Snipen, Lars-Gustav Hansen, Thomas F Baalsrud, Helle Tessand Nederbragt, Alexander Johan Hanel, Reinhold Salzburger, Walter Stenseth, Nils Christian Jakobsen, Kjetill Sigurd Jentoft, Sissel Evolution of the immune system influences speciation rates in teleost fishes |
author_facet |
Malmstrøm, Martin Matschiner, Michael Tørresen, Ole Kristian Star, Bastiaan Snipen, Lars-Gustav Hansen, Thomas F Baalsrud, Helle Tessand Nederbragt, Alexander Johan Hanel, Reinhold Salzburger, Walter Stenseth, Nils Christian Jakobsen, Kjetill Sigurd Jentoft, Sissel |
author_sort |
Malmstrøm, Martin |
title |
Evolution of the immune system influences speciation rates in teleost fishes |
title_short |
Evolution of the immune system influences speciation rates in teleost fishes |
title_full |
Evolution of the immune system influences speciation rates in teleost fishes |
title_fullStr |
Evolution of the immune system influences speciation rates in teleost fishes |
title_full_unstemmed |
Evolution of the immune system influences speciation rates in teleost fishes |
title_sort |
evolution of the immune system influences speciation rates in teleost fishes |
publishDate |
2016 |
url |
http://hdl.handle.net/11250/2484950 https://doi.org/10.1038/ng.3645 |
genre |
atlantic cod |
genre_facet |
atlantic cod |
op_source |
1204-1210 48 Nature Genetics 10 |
op_relation |
Norges forskningsråd: 179569 Norges forskningsråd: 222378 Nature Genetics. 2016, 48 (10), 1204-1210. urn:issn:1061-4036 http://hdl.handle.net/11250/2484950 https://doi.org/10.1038/ng.3645 cristin:1392896 |
op_doi |
https://doi.org/10.1038/ng.3645 |
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Nature Genetics |
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48 |
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10 |
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1204 |
op_container_end_page |
1210 |
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1766357888723320832 |