Changes in plasma and liver glutathione levels in Atlantic salmon Salmo salar suffering from infectious salmon anemia (ISA)
The levels of reduced glutathione (GSH) in plasma and liver in healthy Atlantic salmon Salmo salar and salmon suffering from infectious salmon anaemia (ISA) were measured using high-performance liquid chromatography (HPLC). The infected salmon had an increased level of plasma GSH Compared to control...
Published in: | Diseases of Aquatic Organisms |
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Language: | English |
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1992
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Online Access: | http://hdl.handle.net/11250/108808 https://doi.org/10.3354/dao014031 |
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ftimr:oai:imr.brage.unit.no:11250/108808 2023-05-15T15:31:09+02:00 Changes in plasma and liver glutathione levels in Atlantic salmon Salmo salar suffering from infectious salmon anemia (ISA) Hjeltnes, Brit K. Samuelsen, Ole Bent Svardal, Asbjørn Martin 1992-10-08 262362 bytes application/pdf http://hdl.handle.net/11250/108808 https://doi.org/10.3354/dao014031 eng eng urn:issn:0177-5103 http://hdl.handle.net/11250/108808 http://dx.doi.org/10.3354/dao014031 31-33 14 Diseases of Aquatic Organisms 1 laks salmon infectious salmon anaemia (ISA) infeksiøs lakseanemi (ILA) fiskesykdommer fish diseases Journal article Peer reviewed 1992 ftimr https://doi.org/10.3354/dao014031 2021-09-23T20:14:48Z The levels of reduced glutathione (GSH) in plasma and liver in healthy Atlantic salmon Salmo salar and salmon suffering from infectious salmon anaemia (ISA) were measured using high-performance liquid chromatography (HPLC). The infected salmon had an increased level of plasma GSH Compared to controls, the mean values being 72.31 +/- 11.56 and 52.8 +/- 2.92 muM, respectively. The increased GSH level in plasma was found to be significant (p < 0.0001, unpaired t-test) and may be a result of intracellular release. The hepatic GSH level was significantly lower in the infected salmons compared to controls (p < 0,0001, unpaired t-test) and the mean values were calculated to be 1618.7 +/- 543.7 and 2512.1 +/- 326.9 nmol g-1 liver (wet wt), respectively. A decrease in hepatic GSH of up to 70 % in diseased fish compared to controls was observed. Such low levels of GSH in the liver may affect the capability of this organ in the transformation and excretion of xenobiotics from the body. Article in Journal/Newspaper Atlantic salmon Salmo salar Institute for Marine Research: Brage IMR Diseases of Aquatic Organisms 14 31 33 |
institution |
Open Polar |
collection |
Institute for Marine Research: Brage IMR |
op_collection_id |
ftimr |
language |
English |
topic |
laks salmon infectious salmon anaemia (ISA) infeksiøs lakseanemi (ILA) fiskesykdommer fish diseases |
spellingShingle |
laks salmon infectious salmon anaemia (ISA) infeksiøs lakseanemi (ILA) fiskesykdommer fish diseases Hjeltnes, Brit K. Samuelsen, Ole Bent Svardal, Asbjørn Martin Changes in plasma and liver glutathione levels in Atlantic salmon Salmo salar suffering from infectious salmon anemia (ISA) |
topic_facet |
laks salmon infectious salmon anaemia (ISA) infeksiøs lakseanemi (ILA) fiskesykdommer fish diseases |
description |
The levels of reduced glutathione (GSH) in plasma and liver in healthy Atlantic salmon Salmo salar and salmon suffering from infectious salmon anaemia (ISA) were measured using high-performance liquid chromatography (HPLC). The infected salmon had an increased level of plasma GSH Compared to controls, the mean values being 72.31 +/- 11.56 and 52.8 +/- 2.92 muM, respectively. The increased GSH level in plasma was found to be significant (p < 0.0001, unpaired t-test) and may be a result of intracellular release. The hepatic GSH level was significantly lower in the infected salmons compared to controls (p < 0,0001, unpaired t-test) and the mean values were calculated to be 1618.7 +/- 543.7 and 2512.1 +/- 326.9 nmol g-1 liver (wet wt), respectively. A decrease in hepatic GSH of up to 70 % in diseased fish compared to controls was observed. Such low levels of GSH in the liver may affect the capability of this organ in the transformation and excretion of xenobiotics from the body. |
format |
Article in Journal/Newspaper |
author |
Hjeltnes, Brit K. Samuelsen, Ole Bent Svardal, Asbjørn Martin |
author_facet |
Hjeltnes, Brit K. Samuelsen, Ole Bent Svardal, Asbjørn Martin |
author_sort |
Hjeltnes, Brit K. |
title |
Changes in plasma and liver glutathione levels in Atlantic salmon Salmo salar suffering from infectious salmon anemia (ISA) |
title_short |
Changes in plasma and liver glutathione levels in Atlantic salmon Salmo salar suffering from infectious salmon anemia (ISA) |
title_full |
Changes in plasma and liver glutathione levels in Atlantic salmon Salmo salar suffering from infectious salmon anemia (ISA) |
title_fullStr |
Changes in plasma and liver glutathione levels in Atlantic salmon Salmo salar suffering from infectious salmon anemia (ISA) |
title_full_unstemmed |
Changes in plasma and liver glutathione levels in Atlantic salmon Salmo salar suffering from infectious salmon anemia (ISA) |
title_sort |
changes in plasma and liver glutathione levels in atlantic salmon salmo salar suffering from infectious salmon anemia (isa) |
publishDate |
1992 |
url |
http://hdl.handle.net/11250/108808 https://doi.org/10.3354/dao014031 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
31-33 14 Diseases of Aquatic Organisms 1 |
op_relation |
urn:issn:0177-5103 http://hdl.handle.net/11250/108808 http://dx.doi.org/10.3354/dao014031 |
op_doi |
https://doi.org/10.3354/dao014031 |
container_title |
Diseases of Aquatic Organisms |
container_volume |
14 |
container_start_page |
31 |
op_container_end_page |
33 |
_version_ |
1766361638900858880 |