Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment furunculosis in Atlantic salmon Salmo salar held seawater
This study was performed to determine the efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, in the treatment of experimental induced furunculosis in Atlantic salmon Salmo salar held in seawater. Two strains of the causative bacterium Aeromonas salmonicida subsp. s...
Published in: | Diseases of Aquatic Organisms |
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Language: | English |
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1999
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Online Access: | http://hdl.handle.net/11250/108374 https://doi.org/10.3354/dao037053 |
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ftimr:oai:imr.brage.unit.no:11250/108374 2023-05-15T15:31:45+02:00 Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment furunculosis in Atlantic salmon Salmo salar held seawater Samuelsen, Ole Bent Hjeltnes, Brit K. Torkildsen, Lise 1999-06-23 630696 bytes application/pdf http://hdl.handle.net/11250/108374 https://doi.org/10.3354/dao037053 eng eng urn:issn:0177-5103 http://hdl.handle.net/11250/108374 http://dx.doi.org/10.3354/dao037053 53-59 37 Diseases of Aquatic Organisms 1 laks salmon furunculosis Journal article Peer reviewed 1999 ftimr https://doi.org/10.3354/dao037053 2021-09-23T20:16:10Z This study was performed to determine the efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, in the treatment of experimental induced furunculosis in Atlantic salmon Salmo salar held in seawater. Two strains of the causative bacterium Aeromonas salmonicida subsp. salmonicida, 1 sensitive (VI-88/09/03175) and 1 resistant (3475/90) to oxolinic acid, were used. In 2 trials, cohabitational challenges were performed by introducing 8 fish challenged in advance by an intraperitoneal injection of 2.2 x 10(4) colony forming units of strain 3475/90 (Trial 1) or strain VI-88/09/03175 (Trial 2) to 10 aquaria each containing 40 healthy fish. The treatment groups in both trials consisted of 4 groups receiving either oxolinic acid (2 groups) or Vetoquinol (2 groups) and 1 control group. An unchallenged, unmedicated group was used to determine the natural mortality in the population. The recommended therapeutic dose of 25 mg oxolinic acid kg(-1) fish at Days 1, 2, 4, 6, 8 and 10 following initiation of treatment was used. Oral medication initiated at Day 10 (Trial 1) or Day 11 (Trial 2) following challenge significantly (p < 0.05) lowered the specific mortality in all drug-treated groups compared to the untreated control groups. Mortality in Vetoquinol-treated groups was significantly (p < 0.05) lower than in oxolinic acid-treated groups in Trial 1 whereas no significant (p < 0.05) difference in survival rate was found between the medicated groups in Trial 2. Article in Journal/Newspaper Atlantic salmon Salmo salar Institute for Marine Research: Brage IMR Diseases of Aquatic Organisms 37 53 59 |
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Open Polar |
collection |
Institute for Marine Research: Brage IMR |
op_collection_id |
ftimr |
language |
English |
topic |
laks salmon furunculosis |
spellingShingle |
laks salmon furunculosis Samuelsen, Ole Bent Hjeltnes, Brit K. Torkildsen, Lise Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment furunculosis in Atlantic salmon Salmo salar held seawater |
topic_facet |
laks salmon furunculosis |
description |
This study was performed to determine the efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, in the treatment of experimental induced furunculosis in Atlantic salmon Salmo salar held in seawater. Two strains of the causative bacterium Aeromonas salmonicida subsp. salmonicida, 1 sensitive (VI-88/09/03175) and 1 resistant (3475/90) to oxolinic acid, were used. In 2 trials, cohabitational challenges were performed by introducing 8 fish challenged in advance by an intraperitoneal injection of 2.2 x 10(4) colony forming units of strain 3475/90 (Trial 1) or strain VI-88/09/03175 (Trial 2) to 10 aquaria each containing 40 healthy fish. The treatment groups in both trials consisted of 4 groups receiving either oxolinic acid (2 groups) or Vetoquinol (2 groups) and 1 control group. An unchallenged, unmedicated group was used to determine the natural mortality in the population. The recommended therapeutic dose of 25 mg oxolinic acid kg(-1) fish at Days 1, 2, 4, 6, 8 and 10 following initiation of treatment was used. Oral medication initiated at Day 10 (Trial 1) or Day 11 (Trial 2) following challenge significantly (p < 0.05) lowered the specific mortality in all drug-treated groups compared to the untreated control groups. Mortality in Vetoquinol-treated groups was significantly (p < 0.05) lower than in oxolinic acid-treated groups in Trial 1 whereas no significant (p < 0.05) difference in survival rate was found between the medicated groups in Trial 2. |
format |
Article in Journal/Newspaper |
author |
Samuelsen, Ole Bent Hjeltnes, Brit K. Torkildsen, Lise |
author_facet |
Samuelsen, Ole Bent Hjeltnes, Brit K. Torkildsen, Lise |
author_sort |
Samuelsen, Ole Bent |
title |
Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment furunculosis in Atlantic salmon Salmo salar held seawater |
title_short |
Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment furunculosis in Atlantic salmon Salmo salar held seawater |
title_full |
Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment furunculosis in Atlantic salmon Salmo salar held seawater |
title_fullStr |
Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment furunculosis in Atlantic salmon Salmo salar held seawater |
title_full_unstemmed |
Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment furunculosis in Atlantic salmon Salmo salar held seawater |
title_sort |
efficacy of orally administered oxolinic acid and vetoquinol, an oxolinic acid ester, for the treatment furunculosis in atlantic salmon salmo salar held seawater |
publishDate |
1999 |
url |
http://hdl.handle.net/11250/108374 https://doi.org/10.3354/dao037053 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
53-59 37 Diseases of Aquatic Organisms 1 |
op_relation |
urn:issn:0177-5103 http://hdl.handle.net/11250/108374 http://dx.doi.org/10.3354/dao037053 |
op_doi |
https://doi.org/10.3354/dao037053 |
container_title |
Diseases of Aquatic Organisms |
container_volume |
37 |
container_start_page |
53 |
op_container_end_page |
59 |
_version_ |
1766362271030706176 |