A population-based follow-up study shows high psychosis risk in women with PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% of women. Besides metabolic and fertility aspects, attention has lately been directed towards the detrimental effect of PCOS on psychological health. The objective of the study was to investigate whether women with P...
Published in: | Archives of Women's Mental Health |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Springer
2021
|
Subjects: | |
Online Access: | http://hdl.handle.net/10044/1/93457 https://doi.org/10.1007/s00737-021-01195-4 |
id |
ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/93457 |
---|---|
record_format |
openpolar |
spelling |
ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/93457 2023-05-15T17:42:45+02:00 A population-based follow-up study shows high psychosis risk in women with PCOS Karjula, S Arffman, RK Morin-Papunen, L Franks, S Jarvelin, M-R Tapanainen, JS Miettunen, J Piltonen, TT 2021-11-09 http://hdl.handle.net/10044/1/93457 https://doi.org/10.1007/s00737-021-01195-4 English eng Springer Archives of Womens Mental Health 1434-1816 http://hdl.handle.net/10044/1/93457 doi:10.1007/s00737-021-01195-4 © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. http://creativecommons.org/licenses/by/4.0/ CC-BY 311 301 Science & Technology Life Sciences & Biomedicine Psychiatry Polycystic ovary syndrome PCOS Psychosis Hirsutism Testosterone POLYCYSTIC-OVARY-SYNDROME OLIGOMENORRHEA AND/OR HIRSUTISM SELF-REPORTED SYMPTOMS SEX-DIFFERENCES WEIGHT-GAIN SCHIZOPHRENIA PREVALENCE DISORDERS CARE ESTROGEN Adult Female Follow-Up Studies Humans Hyperandrogenism Middle Aged Psychotic Disorders 1701 Psychology 1702 Cognitive Sciences Journal Article 2021 ftimperialcol https://doi.org/10.1007/s00737-021-01195-4 2022-03-31T22:40:56Z Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% of women. Besides metabolic and fertility aspects, attention has lately been directed towards the detrimental effect of PCOS on psychological health. The objective of the study was to investigate whether women with PCOS are at higher risk for psychotic disorders. The study population derives from the Northern Finland Birth Cohort 1966 (N = 5889 women). The women with PCOS were identified by two simple questions on oligo-amenorrhea and hirsutism at age 31. Women reporting both symptoms were considered PCOS (N = 124) and asymptomatic women as controls (N = 2145). The diagnosis of psychosis was traced using multiple national registers up to the year 2016. Symptoms of psychopathology were identified using validated questionnaires at age 31. Women with PCOS showed an increased risk for any psychosis by age 50 (HR [95% CI] 2.99, [1.52–5.82]). Also, the risk for psychosis after age 31 was increased (HR 2.68 [1.21–5.92]). The results did not change after adjusting for parental history of psychosis, nor were they explained by body mass index or hyperandrogenism at adulthood. The scales of psychopathology differed between women with PCOS and non-PCOS controls showing more psychopathologies among the affected women. PCOS cases were found to be at a three-fold risk for psychosis, and they had increased psychopathological symptoms. PCOS should be taken into consideration when treating women in psychiatric care. More studies are required to further assess the relationship between PCOS and psychotic diseases. Article in Journal/Newspaper Northern Finland Imperial College London: Spiral Archives of Women's Mental Health 25 2 301 311 |
institution |
Open Polar |
collection |
Imperial College London: Spiral |
op_collection_id |
ftimperialcol |
language |
English |
topic |
Science & Technology Life Sciences & Biomedicine Psychiatry Polycystic ovary syndrome PCOS Psychosis Hirsutism Testosterone POLYCYSTIC-OVARY-SYNDROME OLIGOMENORRHEA AND/OR HIRSUTISM SELF-REPORTED SYMPTOMS SEX-DIFFERENCES WEIGHT-GAIN SCHIZOPHRENIA PREVALENCE DISORDERS CARE ESTROGEN Adult Female Follow-Up Studies Humans Hyperandrogenism Middle Aged Psychotic Disorders 1701 Psychology 1702 Cognitive Sciences |
spellingShingle |
Science & Technology Life Sciences & Biomedicine Psychiatry Polycystic ovary syndrome PCOS Psychosis Hirsutism Testosterone POLYCYSTIC-OVARY-SYNDROME OLIGOMENORRHEA AND/OR HIRSUTISM SELF-REPORTED SYMPTOMS SEX-DIFFERENCES WEIGHT-GAIN SCHIZOPHRENIA PREVALENCE DISORDERS CARE ESTROGEN Adult Female Follow-Up Studies Humans Hyperandrogenism Middle Aged Psychotic Disorders 1701 Psychology 1702 Cognitive Sciences Karjula, S Arffman, RK Morin-Papunen, L Franks, S Jarvelin, M-R Tapanainen, JS Miettunen, J Piltonen, TT A population-based follow-up study shows high psychosis risk in women with PCOS |
topic_facet |
Science & Technology Life Sciences & Biomedicine Psychiatry Polycystic ovary syndrome PCOS Psychosis Hirsutism Testosterone POLYCYSTIC-OVARY-SYNDROME OLIGOMENORRHEA AND/OR HIRSUTISM SELF-REPORTED SYMPTOMS SEX-DIFFERENCES WEIGHT-GAIN SCHIZOPHRENIA PREVALENCE DISORDERS CARE ESTROGEN Adult Female Follow-Up Studies Humans Hyperandrogenism Middle Aged Psychotic Disorders 1701 Psychology 1702 Cognitive Sciences |
description |
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% of women. Besides metabolic and fertility aspects, attention has lately been directed towards the detrimental effect of PCOS on psychological health. The objective of the study was to investigate whether women with PCOS are at higher risk for psychotic disorders. The study population derives from the Northern Finland Birth Cohort 1966 (N = 5889 women). The women with PCOS were identified by two simple questions on oligo-amenorrhea and hirsutism at age 31. Women reporting both symptoms were considered PCOS (N = 124) and asymptomatic women as controls (N = 2145). The diagnosis of psychosis was traced using multiple national registers up to the year 2016. Symptoms of psychopathology were identified using validated questionnaires at age 31. Women with PCOS showed an increased risk for any psychosis by age 50 (HR [95% CI] 2.99, [1.52–5.82]). Also, the risk for psychosis after age 31 was increased (HR 2.68 [1.21–5.92]). The results did not change after adjusting for parental history of psychosis, nor were they explained by body mass index or hyperandrogenism at adulthood. The scales of psychopathology differed between women with PCOS and non-PCOS controls showing more psychopathologies among the affected women. PCOS cases were found to be at a three-fold risk for psychosis, and they had increased psychopathological symptoms. PCOS should be taken into consideration when treating women in psychiatric care. More studies are required to further assess the relationship between PCOS and psychotic diseases. |
format |
Article in Journal/Newspaper |
author |
Karjula, S Arffman, RK Morin-Papunen, L Franks, S Jarvelin, M-R Tapanainen, JS Miettunen, J Piltonen, TT |
author_facet |
Karjula, S Arffman, RK Morin-Papunen, L Franks, S Jarvelin, M-R Tapanainen, JS Miettunen, J Piltonen, TT |
author_sort |
Karjula, S |
title |
A population-based follow-up study shows high psychosis risk in women with PCOS |
title_short |
A population-based follow-up study shows high psychosis risk in women with PCOS |
title_full |
A population-based follow-up study shows high psychosis risk in women with PCOS |
title_fullStr |
A population-based follow-up study shows high psychosis risk in women with PCOS |
title_full_unstemmed |
A population-based follow-up study shows high psychosis risk in women with PCOS |
title_sort |
population-based follow-up study shows high psychosis risk in women with pcos |
publisher |
Springer |
publishDate |
2021 |
url |
http://hdl.handle.net/10044/1/93457 https://doi.org/10.1007/s00737-021-01195-4 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
311 301 |
op_relation |
Archives of Womens Mental Health 1434-1816 http://hdl.handle.net/10044/1/93457 doi:10.1007/s00737-021-01195-4 |
op_rights |
© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00737-021-01195-4 |
container_title |
Archives of Women's Mental Health |
container_volume |
25 |
container_issue |
2 |
container_start_page |
301 |
op_container_end_page |
311 |
_version_ |
1766144652053839872 |