Vitamin D intake and the risk of colorectal cancer: an updated meta-analysis and systematic review of case-control and prospective cohort studies
Obesity, a sedentary lifestyle, high red meat consumption and alcohol, and tobacco are considered the driving factors behind colorectal cancer (CRC) worldwide. Both diet and lifestyle are recognized to play an important role in the prevention of CRC. Forty years later, the vitamin D–cancer hypothesi...
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ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/89892 2023-05-15T17:22:57+02:00 Vitamin D intake and the risk of colorectal cancer: an updated meta-analysis and systematic review of case-control and prospective cohort studies Boughanem, H Canudas, S Hernandez-Alonso, P Becerra-Tomas, N Babio, N Salas-Salvado, J Macias-Gonzalez, M 2021-05-31 http://hdl.handle.net/10044/1/89892 https://doi.org/10.3390/cancers13112814 English eng MDPI AG Cancers 2072-6694 http://hdl.handle.net/10044/1/89892 doi:10.3390/cancers13112814 © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY 19 1 Science & Technology Life Sciences & Biomedicine Oncology vitamin D intake meta-analysis systematic review colorectal cancer incidence case-control prospective DIETARY CALCIUM DAIRY-PRODUCTS RECTAL-CANCER COLON-CANCER ASSOCIATION MICRONUTRIENTS POLYMORPHISMS NEWFOUNDLAND INHIBITION PHOSPHORUS 1112 Oncology and Carcinogenesis Journal Article 2021 ftimperialcol https://doi.org/10.3390/cancers13112814 2021-07-01T22:39:05Z Obesity, a sedentary lifestyle, high red meat consumption and alcohol, and tobacco are considered the driving factors behind colorectal cancer (CRC) worldwide. Both diet and lifestyle are recognized to play an important role in the prevention of CRC. Forty years later, the vitamin D–cancer hypothesis is considered consistent. However, the relationship between low vitamin D intake and CRC is still controversial. The aim of this meta-analysis is to determine the associations between Vitamin D intake and CRC. MEDLINE-PubMed and Cochrane databases were searched up to May 2020 for studies evaluating the association between vitamin D intake (from foods and supplements) and CRC. Two reviewers, working independently, screened all titles and abstracts to identify the studies that met the inclusion criteria (case-control or prospective cohort (PC) studies published in English). Data were pooled by the generic inverse variance method using a random or fixed effect model. Heterogeneity was identified using the Cochran Q-test and quantified by the I2 statistic. A total of 31 original studies were included for the quantitative meta-analysis, comprising a total 47.540 cases and 70.567 controls in case-control studies, and a total of 14.676 CRC-incident cases (out of 808.130 subjects in PC studies) from 17 countries. A significant 25% lower risk was reported comparing the highest vs. the lowest dietary vitamin D consumption and CRC risk (odds ratio (95% confidence interval): 0.75 (0.67; 0.85)) in case-control studies, whereas a non-significant association was reported in case of prospective studies (hazard ratio (95% confidence interval): 0.94 (0.79; 1.11). The present meta-analysis demonstrates that high dietary vitamin D is associated to CRC prevention. However, larger and high-quality prospective studies and clinical trials are warranted to confirm this association. Article in Journal/Newspaper Newfoundland Imperial College London: Spiral Cancers 13 11 2814 |
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Open Polar |
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Imperial College London: Spiral |
op_collection_id |
ftimperialcol |
language |
English |
topic |
Science & Technology Life Sciences & Biomedicine Oncology vitamin D intake meta-analysis systematic review colorectal cancer incidence case-control prospective DIETARY CALCIUM DAIRY-PRODUCTS RECTAL-CANCER COLON-CANCER ASSOCIATION MICRONUTRIENTS POLYMORPHISMS NEWFOUNDLAND INHIBITION PHOSPHORUS 1112 Oncology and Carcinogenesis |
spellingShingle |
Science & Technology Life Sciences & Biomedicine Oncology vitamin D intake meta-analysis systematic review colorectal cancer incidence case-control prospective DIETARY CALCIUM DAIRY-PRODUCTS RECTAL-CANCER COLON-CANCER ASSOCIATION MICRONUTRIENTS POLYMORPHISMS NEWFOUNDLAND INHIBITION PHOSPHORUS 1112 Oncology and Carcinogenesis Boughanem, H Canudas, S Hernandez-Alonso, P Becerra-Tomas, N Babio, N Salas-Salvado, J Macias-Gonzalez, M Vitamin D intake and the risk of colorectal cancer: an updated meta-analysis and systematic review of case-control and prospective cohort studies |
topic_facet |
Science & Technology Life Sciences & Biomedicine Oncology vitamin D intake meta-analysis systematic review colorectal cancer incidence case-control prospective DIETARY CALCIUM DAIRY-PRODUCTS RECTAL-CANCER COLON-CANCER ASSOCIATION MICRONUTRIENTS POLYMORPHISMS NEWFOUNDLAND INHIBITION PHOSPHORUS 1112 Oncology and Carcinogenesis |
description |
Obesity, a sedentary lifestyle, high red meat consumption and alcohol, and tobacco are considered the driving factors behind colorectal cancer (CRC) worldwide. Both diet and lifestyle are recognized to play an important role in the prevention of CRC. Forty years later, the vitamin D–cancer hypothesis is considered consistent. However, the relationship between low vitamin D intake and CRC is still controversial. The aim of this meta-analysis is to determine the associations between Vitamin D intake and CRC. MEDLINE-PubMed and Cochrane databases were searched up to May 2020 for studies evaluating the association between vitamin D intake (from foods and supplements) and CRC. Two reviewers, working independently, screened all titles and abstracts to identify the studies that met the inclusion criteria (case-control or prospective cohort (PC) studies published in English). Data were pooled by the generic inverse variance method using a random or fixed effect model. Heterogeneity was identified using the Cochran Q-test and quantified by the I2 statistic. A total of 31 original studies were included for the quantitative meta-analysis, comprising a total 47.540 cases and 70.567 controls in case-control studies, and a total of 14.676 CRC-incident cases (out of 808.130 subjects in PC studies) from 17 countries. A significant 25% lower risk was reported comparing the highest vs. the lowest dietary vitamin D consumption and CRC risk (odds ratio (95% confidence interval): 0.75 (0.67; 0.85)) in case-control studies, whereas a non-significant association was reported in case of prospective studies (hazard ratio (95% confidence interval): 0.94 (0.79; 1.11). The present meta-analysis demonstrates that high dietary vitamin D is associated to CRC prevention. However, larger and high-quality prospective studies and clinical trials are warranted to confirm this association. |
format |
Article in Journal/Newspaper |
author |
Boughanem, H Canudas, S Hernandez-Alonso, P Becerra-Tomas, N Babio, N Salas-Salvado, J Macias-Gonzalez, M |
author_facet |
Boughanem, H Canudas, S Hernandez-Alonso, P Becerra-Tomas, N Babio, N Salas-Salvado, J Macias-Gonzalez, M |
author_sort |
Boughanem, H |
title |
Vitamin D intake and the risk of colorectal cancer: an updated meta-analysis and systematic review of case-control and prospective cohort studies |
title_short |
Vitamin D intake and the risk of colorectal cancer: an updated meta-analysis and systematic review of case-control and prospective cohort studies |
title_full |
Vitamin D intake and the risk of colorectal cancer: an updated meta-analysis and systematic review of case-control and prospective cohort studies |
title_fullStr |
Vitamin D intake and the risk of colorectal cancer: an updated meta-analysis and systematic review of case-control and prospective cohort studies |
title_full_unstemmed |
Vitamin D intake and the risk of colorectal cancer: an updated meta-analysis and systematic review of case-control and prospective cohort studies |
title_sort |
vitamin d intake and the risk of colorectal cancer: an updated meta-analysis and systematic review of case-control and prospective cohort studies |
publisher |
MDPI AG |
publishDate |
2021 |
url |
http://hdl.handle.net/10044/1/89892 https://doi.org/10.3390/cancers13112814 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
19 1 |
op_relation |
Cancers 2072-6694 http://hdl.handle.net/10044/1/89892 doi:10.3390/cancers13112814 |
op_rights |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/cancers13112814 |
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Cancers |
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13 |
container_issue |
11 |
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2814 |
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1766109893116297216 |