Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in Finland
Objectives Farming as an occupation is considered a risk factor for asthma and reduced lung function. By contrast, living on a farm during infancy has been reported to be associated with lower risk of asthma in adulthood. However, little is known about the association between farming environment dur...
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ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/85533 2023-05-15T17:42:52+02:00 Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in Finland Lampi, J Koskela, H Hartikainen, A-L Ramasamy, A Alves, AC Jaervelin, M-R Pekkanen, J 2015-06-30 http://hdl.handle.net/10044/1/85533 https://doi.org/10.1136/bmjopen-2014-007350 English eng BMJ Journals BMJ Open 2044-6055 http://hdl.handle.net/10044/1/85533 doi:10.1136/bmjopen-2014-007350 © 2015 The Author(s). This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ CC-BY-NC 7 1 Science & Technology Life Sciences & Biomedicine Medicine General & Internal General & Internal Medicine RESPIRATORY-FUNCTION ASTHMA EXPOSURE ATOPY ENDOTOXIN PREVALENCE WHEEZE WOMEN MEN EPIDEMIOLOGY OCCUPATIONAL & INDUSTRIAL MEDICINE RESPIRATORY MEDICINE (see Thoracic Medicine) Adult Agriculture Animals Domestic Cats Cohort Studies Dogs Environmental Exposure Female Finland Forced Expiratory Volume Humans Lung Male Pets Prospective Studies Protective Factors Sex Factors Spirometry Vital Capacity 1103 Clinical Sciences 1117 Public Health and Health Services 1199 Other Medical and Health Sciences Journal Article 2015 ftimperialcol https://doi.org/10.1136/bmjopen-2014-007350 2021-01-21T23:39:16Z Objectives Farming as an occupation is considered a risk factor for asthma and reduced lung function. By contrast, living on a farm during infancy has been reported to be associated with lower risk of asthma in adulthood. However, little is known about the association between farming environment during infancy and lung function in adulthood. We aimed to study the prospective longitudinal association between farming environment during infancy and lung function in adulthood. Design A prospective birth cohort study. Setting Northern Finland. Participants 5666 participants born in 1966 were followed up at the age of 31 years. Primary outcome measures Spirometry at the age of 31 years. Results To be born into a farmer’s family was associated with higher forced expiratory volume in 1 s (FEV1) (36 mL; 95% CI 6 to 67 mL) and forced vital capacity (FVC) (40 mL; 95% CI 5 to 75 mL) at the age of 31 years. Contact with farm animals during infancy was associated with higher FEV1. No associations were seen with FEV1/FVC (FEV1/FVC ratio). Having dogs in childhood revealed similar associations. There was a suggestive dose-dependent association with the number of animal species during childhood and higher FEV1 and FVC at adulthood, especially among women. Conclusions Farming environment in early life may have a positive impact on lung function in adulthood. Article in Journal/Newspaper Northern Finland Imperial College London: Spiral BMJ Open 5 7 e007350 |
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Open Polar |
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Imperial College London: Spiral |
op_collection_id |
ftimperialcol |
language |
English |
topic |
Science & Technology Life Sciences & Biomedicine Medicine General & Internal General & Internal Medicine RESPIRATORY-FUNCTION ASTHMA EXPOSURE ATOPY ENDOTOXIN PREVALENCE WHEEZE WOMEN MEN EPIDEMIOLOGY OCCUPATIONAL & INDUSTRIAL MEDICINE RESPIRATORY MEDICINE (see Thoracic Medicine) Adult Agriculture Animals Domestic Cats Cohort Studies Dogs Environmental Exposure Female Finland Forced Expiratory Volume Humans Lung Male Pets Prospective Studies Protective Factors Sex Factors Spirometry Vital Capacity 1103 Clinical Sciences 1117 Public Health and Health Services 1199 Other Medical and Health Sciences |
spellingShingle |
Science & Technology Life Sciences & Biomedicine Medicine General & Internal General & Internal Medicine RESPIRATORY-FUNCTION ASTHMA EXPOSURE ATOPY ENDOTOXIN PREVALENCE WHEEZE WOMEN MEN EPIDEMIOLOGY OCCUPATIONAL & INDUSTRIAL MEDICINE RESPIRATORY MEDICINE (see Thoracic Medicine) Adult Agriculture Animals Domestic Cats Cohort Studies Dogs Environmental Exposure Female Finland Forced Expiratory Volume Humans Lung Male Pets Prospective Studies Protective Factors Sex Factors Spirometry Vital Capacity 1103 Clinical Sciences 1117 Public Health and Health Services 1199 Other Medical and Health Sciences Lampi, J Koskela, H Hartikainen, A-L Ramasamy, A Alves, AC Jaervelin, M-R Pekkanen, J Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in Finland |
topic_facet |
Science & Technology Life Sciences & Biomedicine Medicine General & Internal General & Internal Medicine RESPIRATORY-FUNCTION ASTHMA EXPOSURE ATOPY ENDOTOXIN PREVALENCE WHEEZE WOMEN MEN EPIDEMIOLOGY OCCUPATIONAL & INDUSTRIAL MEDICINE RESPIRATORY MEDICINE (see Thoracic Medicine) Adult Agriculture Animals Domestic Cats Cohort Studies Dogs Environmental Exposure Female Finland Forced Expiratory Volume Humans Lung Male Pets Prospective Studies Protective Factors Sex Factors Spirometry Vital Capacity 1103 Clinical Sciences 1117 Public Health and Health Services 1199 Other Medical and Health Sciences |
description |
Objectives Farming as an occupation is considered a risk factor for asthma and reduced lung function. By contrast, living on a farm during infancy has been reported to be associated with lower risk of asthma in adulthood. However, little is known about the association between farming environment during infancy and lung function in adulthood. We aimed to study the prospective longitudinal association between farming environment during infancy and lung function in adulthood. Design A prospective birth cohort study. Setting Northern Finland. Participants 5666 participants born in 1966 were followed up at the age of 31 years. Primary outcome measures Spirometry at the age of 31 years. Results To be born into a farmer’s family was associated with higher forced expiratory volume in 1 s (FEV1) (36 mL; 95% CI 6 to 67 mL) and forced vital capacity (FVC) (40 mL; 95% CI 5 to 75 mL) at the age of 31 years. Contact with farm animals during infancy was associated with higher FEV1. No associations were seen with FEV1/FVC (FEV1/FVC ratio). Having dogs in childhood revealed similar associations. There was a suggestive dose-dependent association with the number of animal species during childhood and higher FEV1 and FVC at adulthood, especially among women. Conclusions Farming environment in early life may have a positive impact on lung function in adulthood. |
format |
Article in Journal/Newspaper |
author |
Lampi, J Koskela, H Hartikainen, A-L Ramasamy, A Alves, AC Jaervelin, M-R Pekkanen, J |
author_facet |
Lampi, J Koskela, H Hartikainen, A-L Ramasamy, A Alves, AC Jaervelin, M-R Pekkanen, J |
author_sort |
Lampi, J |
title |
Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in Finland |
title_short |
Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in Finland |
title_full |
Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in Finland |
title_fullStr |
Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in Finland |
title_full_unstemmed |
Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in Finland |
title_sort |
farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in finland |
publisher |
BMJ Journals |
publishDate |
2015 |
url |
http://hdl.handle.net/10044/1/85533 https://doi.org/10.1136/bmjopen-2014-007350 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
7 1 |
op_relation |
BMJ Open 2044-6055 http://hdl.handle.net/10044/1/85533 doi:10.1136/bmjopen-2014-007350 |
op_rights |
© 2015 The Author(s). This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1136/bmjopen-2014-007350 |
container_title |
BMJ Open |
container_volume |
5 |
container_issue |
7 |
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e007350 |
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1766144787567607808 |