Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort
BACKGROUND: Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. OBJECTIVE: To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast...
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ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/59254 2023-05-15T16:52:55+02:00 Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort Selby, A Munro, A Grimshaw, KE Cornelius, V Keil, T Grabenhenrich, L Clausen, M Dubakiene, R Fiocchi, A Kowalski, ML Papadopoulos, NG Reche, M Sigurdardottir, ST Sprikkelman, AB Xepapadaki, P Mills, ENC Beyer, K Roberts, G England 2018-01-29 http://hdl.handle.net/10044/1/59254 https://doi.org/10.1136/thoraxjnl-2016-209429 eng eng BMJ Publishing Group Thorax © 2018 Article author(s) (or their employer(s) unless otherwise stated in the text of the article). All rights reserved. No commercial use is permitted unless otherwise expressly granted. 1061 1049 Science & Technology Life Sciences & Biomedicine Respiratory System asthma epidemiology paediatric asthma DAY-CARE ATTENDANCE RESPIRATORY HEALTH SURVEY COWS MILK ALLERGY FOOD ALLERGY PRESCHOOL-CHILDREN ASTHMA PREVALENCE PARENTAL SMOKING TOBACCO-SMOKE EXPOSURE SYMPTOMS Asthma Child Preschool Europe Female Follow-Up Studies Humans Hypersensitivity Incidence Infant Male Pregnancy Prenatal Exposure Delayed Effects Prevalence Respiratory Sounds Respiratory Tract Infections Retrospective Studies Risk Factors Surveys and Questionnaires 1103 Clinical Sciences Journal Article 2018 ftimperialcol https://doi.org/10.1136/thoraxjnl-2016-209429 2019-08-15T22:37:28Z BACKGROUND: Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. OBJECTIVE: To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast feeding and smoke exposure. METHODS: Infants from nine countries were recruited into the EuroPrevall birth cohort. At 12 and 24 months, data on wheeze, allergic signs/symptoms, feeding, smoke exposure, infections and day care attendance were collected using questionnaires. Poisson regression was used to assess risk factors for wheeze. RESULTS: 12 049 infants were recruited. Data from the second year of life were available in 8805 (73.1%). The prevalence of wheeze in the second year of life ranged from <2% in Lodz (Poland) and Vilnius (Lithuania) to 13.1% (95% CI 10.7% to 15.5%) in Southampton (UK) and 17.2% (95% CI 15.0% 19.5%) in Reykjavik (Iceland). In multivariable analysis, frequent lower respiratory tract infections in the first and second years of life (incidence rate ratio (IRR) 1.9 (95% CI 1.3 to 2.6) and 2.5 (95% CI 1.9 to3.4), respectively), postnatal maternal smoking (IRR 1.6, 95% CI 1.1 to 2.4), day care attendance (IRR 1.6, 95% CI 1.1 to 2.5) and male gender (IRR 1.3, 95% CI 1.0 to 1.7) were associated with wheeze. The strength of their association with wheeze differed between countries. Food allergy and breast feeding were not independently associated with wheeze. CONCLUSION: The prevalence of early childhood wheeze varied considerably across Europe. Lower respiratory tract infections, day care attendance, postnatal smoke exposure and male gender are important risk factors. Further research is needed to identify additional modifiable risk factors that may differ between countries. Article in Journal/Newspaper Iceland Imperial College London: Spiral Thorax 73 11 1049 1061 |
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Open Polar |
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Imperial College London: Spiral |
op_collection_id |
ftimperialcol |
language |
English |
topic |
Science & Technology Life Sciences & Biomedicine Respiratory System asthma epidemiology paediatric asthma DAY-CARE ATTENDANCE RESPIRATORY HEALTH SURVEY COWS MILK ALLERGY FOOD ALLERGY PRESCHOOL-CHILDREN ASTHMA PREVALENCE PARENTAL SMOKING TOBACCO-SMOKE EXPOSURE SYMPTOMS Asthma Child Preschool Europe Female Follow-Up Studies Humans Hypersensitivity Incidence Infant Male Pregnancy Prenatal Exposure Delayed Effects Prevalence Respiratory Sounds Respiratory Tract Infections Retrospective Studies Risk Factors Surveys and Questionnaires 1103 Clinical Sciences |
spellingShingle |
Science & Technology Life Sciences & Biomedicine Respiratory System asthma epidemiology paediatric asthma DAY-CARE ATTENDANCE RESPIRATORY HEALTH SURVEY COWS MILK ALLERGY FOOD ALLERGY PRESCHOOL-CHILDREN ASTHMA PREVALENCE PARENTAL SMOKING TOBACCO-SMOKE EXPOSURE SYMPTOMS Asthma Child Preschool Europe Female Follow-Up Studies Humans Hypersensitivity Incidence Infant Male Pregnancy Prenatal Exposure Delayed Effects Prevalence Respiratory Sounds Respiratory Tract Infections Retrospective Studies Risk Factors Surveys and Questionnaires 1103 Clinical Sciences Selby, A Munro, A Grimshaw, KE Cornelius, V Keil, T Grabenhenrich, L Clausen, M Dubakiene, R Fiocchi, A Kowalski, ML Papadopoulos, NG Reche, M Sigurdardottir, ST Sprikkelman, AB Xepapadaki, P Mills, ENC Beyer, K Roberts, G Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
topic_facet |
Science & Technology Life Sciences & Biomedicine Respiratory System asthma epidemiology paediatric asthma DAY-CARE ATTENDANCE RESPIRATORY HEALTH SURVEY COWS MILK ALLERGY FOOD ALLERGY PRESCHOOL-CHILDREN ASTHMA PREVALENCE PARENTAL SMOKING TOBACCO-SMOKE EXPOSURE SYMPTOMS Asthma Child Preschool Europe Female Follow-Up Studies Humans Hypersensitivity Incidence Infant Male Pregnancy Prenatal Exposure Delayed Effects Prevalence Respiratory Sounds Respiratory Tract Infections Retrospective Studies Risk Factors Surveys and Questionnaires 1103 Clinical Sciences |
description |
BACKGROUND: Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. OBJECTIVE: To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast feeding and smoke exposure. METHODS: Infants from nine countries were recruited into the EuroPrevall birth cohort. At 12 and 24 months, data on wheeze, allergic signs/symptoms, feeding, smoke exposure, infections and day care attendance were collected using questionnaires. Poisson regression was used to assess risk factors for wheeze. RESULTS: 12 049 infants were recruited. Data from the second year of life were available in 8805 (73.1%). The prevalence of wheeze in the second year of life ranged from <2% in Lodz (Poland) and Vilnius (Lithuania) to 13.1% (95% CI 10.7% to 15.5%) in Southampton (UK) and 17.2% (95% CI 15.0% 19.5%) in Reykjavik (Iceland). In multivariable analysis, frequent lower respiratory tract infections in the first and second years of life (incidence rate ratio (IRR) 1.9 (95% CI 1.3 to 2.6) and 2.5 (95% CI 1.9 to3.4), respectively), postnatal maternal smoking (IRR 1.6, 95% CI 1.1 to 2.4), day care attendance (IRR 1.6, 95% CI 1.1 to 2.5) and male gender (IRR 1.3, 95% CI 1.0 to 1.7) were associated with wheeze. The strength of their association with wheeze differed between countries. Food allergy and breast feeding were not independently associated with wheeze. CONCLUSION: The prevalence of early childhood wheeze varied considerably across Europe. Lower respiratory tract infections, day care attendance, postnatal smoke exposure and male gender are important risk factors. Further research is needed to identify additional modifiable risk factors that may differ between countries. |
format |
Article in Journal/Newspaper |
author |
Selby, A Munro, A Grimshaw, KE Cornelius, V Keil, T Grabenhenrich, L Clausen, M Dubakiene, R Fiocchi, A Kowalski, ML Papadopoulos, NG Reche, M Sigurdardottir, ST Sprikkelman, AB Xepapadaki, P Mills, ENC Beyer, K Roberts, G |
author_facet |
Selby, A Munro, A Grimshaw, KE Cornelius, V Keil, T Grabenhenrich, L Clausen, M Dubakiene, R Fiocchi, A Kowalski, ML Papadopoulos, NG Reche, M Sigurdardottir, ST Sprikkelman, AB Xepapadaki, P Mills, ENC Beyer, K Roberts, G |
author_sort |
Selby, A |
title |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_short |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_full |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_fullStr |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_full_unstemmed |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_sort |
prevalence estimates and risk factors for early childhood wheeze across europe: the europrevall birth cohort |
publisher |
BMJ Publishing Group |
publishDate |
2018 |
url |
http://hdl.handle.net/10044/1/59254 https://doi.org/10.1136/thoraxjnl-2016-209429 |
op_coverage |
England |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
1061 1049 |
op_relation |
Thorax |
op_rights |
© 2018 Article author(s) (or their employer(s) unless otherwise stated in the text of the article). All rights reserved. No commercial use is permitted unless otherwise expressly granted. |
op_doi |
https://doi.org/10.1136/thoraxjnl-2016-209429 |
container_title |
Thorax |
container_volume |
73 |
container_issue |
11 |
container_start_page |
1049 |
op_container_end_page |
1061 |
_version_ |
1766043412596785152 |