A genome-wide association study of body mass index across early life and childhood
Background: Several studies have investigated the effect of known adult body mass index (BMI) associated single nucleotide polymorphisms (SNPs) on BMI in childhood. There has been no genome-wide association study (GWAS) of BMI trajectories over childhood. Methods: We conducted a GWAS meta-analysis o...
Published in: | International Journal of Epidemiology |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Oxford University Press (OUP): Policy B - Oxford Open Option D
2015
|
Subjects: | |
Online Access: | http://hdl.handle.net/10044/1/48221 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357106100032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 https://doi.org/10.1093/ije/dyv077 |
id |
ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/48221 |
---|---|
record_format |
openpolar |
spelling |
ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/48221 2023-05-15T17:42:55+02:00 A genome-wide association study of body mass index across early life and childhood Warrington, NM Howe, LD Paternoster, L Kaakinen, M Herrala, S Huikari, V Wu, YY Kemp, JP Timpson, NJ St Pourcain, B Smith, GD Tilling, K Jarvelin, M-R Pennell, CE Evans, DM Lawlor, DA Briollais, L Palmer, LJ 2015-04-16 http://hdl.handle.net/10044/1/48221 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357106100032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 https://doi.org/10.1093/ije/dyv077 English eng Oxford University Press (OUP): Policy B - Oxford Open Option D International Journal of Epidemiology © 2015 The Author all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY 712 700 Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health Body mass index genome-wide association study trajectory childhood ALSPAC Raine ADULT OBESITY COMMON VARIANTS EARLY-ONSET LOCI GENE BMI WEIGHT INFANT FTO DIFFERENTIATION Adenylyl Cyclases Adolescent Body Height Body Weight Child Preschool Chromosomes Human Pair 9 Female Genotype Granulocyte Colony-Stimulating Factor Humans Male Mutation Missense Pediatric Obesity Polymorphism Single Nucleotide RNA-Binding Proteins Receptor Melanocortin Type 4 Epidemiology 0104 Statistics 1117 Public Health And Health Services Journal Article 2015 ftimperialcol https://doi.org/10.1093/ije/dyv077 2018-09-16T05:58:19Z Background: Several studies have investigated the effect of known adult body mass index (BMI) associated single nucleotide polymorphisms (SNPs) on BMI in childhood. There has been no genome-wide association study (GWAS) of BMI trajectories over childhood. Methods: We conducted a GWAS meta-analysis of BMI trajectories from 1 to 17 years of age in 9377 children (77 967 measurements) from the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Western Australian Pregnancy Cohort (Raine) Study. Genome-wide significant loci were examined in a further 3918 individuals (48 530 measurements) from Northern Finland. Linear mixed effects models with smoothing splines were used in each cohort for longitudinal modelling of BMI. Results: A novel SNP, downstream from the FAM120AOS gene on chromosome 9, was detected in the meta-analysis of ALSPAC and Raine. This association was driven by a difference in BMI at 8 years (T allele of rs944990 increased BMI; PSNP = 1.52 × 10−8), with a modest association with change in BMI over time (PWald(Change) = 0.006). Three known adult BMI-associated loci (FTO, MC4R and ADCY3) and one childhood obesity locus (OLFM4) reached genome-wide significance (PWald < 1.13 × 10−8) with BMI at 8 years and/or change over time. Conclusions: This GWAS of BMI trajectories over childhood identified a novel locus that warrants further investigation. We also observed genome-wide significance with previously established obesity loci, making the novel observation that these loci affected both the level and the rate of change in BMI. We have demonstrated that the use of repeated measures data can increase power to allow detection of genetic loci with smaller sample sizes. Article in Journal/Newspaper Northern Finland Imperial College London: Spiral International Journal of Epidemiology 44 2 700 712 |
institution |
Open Polar |
collection |
Imperial College London: Spiral |
op_collection_id |
ftimperialcol |
language |
English |
topic |
Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health Body mass index genome-wide association study trajectory childhood ALSPAC Raine ADULT OBESITY COMMON VARIANTS EARLY-ONSET LOCI GENE BMI WEIGHT INFANT FTO DIFFERENTIATION Adenylyl Cyclases Adolescent Body Height Body Weight Child Preschool Chromosomes Human Pair 9 Female Genotype Granulocyte Colony-Stimulating Factor Humans Male Mutation Missense Pediatric Obesity Polymorphism Single Nucleotide RNA-Binding Proteins Receptor Melanocortin Type 4 Epidemiology 0104 Statistics 1117 Public Health And Health Services |
spellingShingle |
Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health Body mass index genome-wide association study trajectory childhood ALSPAC Raine ADULT OBESITY COMMON VARIANTS EARLY-ONSET LOCI GENE BMI WEIGHT INFANT FTO DIFFERENTIATION Adenylyl Cyclases Adolescent Body Height Body Weight Child Preschool Chromosomes Human Pair 9 Female Genotype Granulocyte Colony-Stimulating Factor Humans Male Mutation Missense Pediatric Obesity Polymorphism Single Nucleotide RNA-Binding Proteins Receptor Melanocortin Type 4 Epidemiology 0104 Statistics 1117 Public Health And Health Services Warrington, NM Howe, LD Paternoster, L Kaakinen, M Herrala, S Huikari, V Wu, YY Kemp, JP Timpson, NJ St Pourcain, B Smith, GD Tilling, K Jarvelin, M-R Pennell, CE Evans, DM Lawlor, DA Briollais, L Palmer, LJ A genome-wide association study of body mass index across early life and childhood |
topic_facet |
Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health Body mass index genome-wide association study trajectory childhood ALSPAC Raine ADULT OBESITY COMMON VARIANTS EARLY-ONSET LOCI GENE BMI WEIGHT INFANT FTO DIFFERENTIATION Adenylyl Cyclases Adolescent Body Height Body Weight Child Preschool Chromosomes Human Pair 9 Female Genotype Granulocyte Colony-Stimulating Factor Humans Male Mutation Missense Pediatric Obesity Polymorphism Single Nucleotide RNA-Binding Proteins Receptor Melanocortin Type 4 Epidemiology 0104 Statistics 1117 Public Health And Health Services |
description |
Background: Several studies have investigated the effect of known adult body mass index (BMI) associated single nucleotide polymorphisms (SNPs) on BMI in childhood. There has been no genome-wide association study (GWAS) of BMI trajectories over childhood. Methods: We conducted a GWAS meta-analysis of BMI trajectories from 1 to 17 years of age in 9377 children (77 967 measurements) from the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Western Australian Pregnancy Cohort (Raine) Study. Genome-wide significant loci were examined in a further 3918 individuals (48 530 measurements) from Northern Finland. Linear mixed effects models with smoothing splines were used in each cohort for longitudinal modelling of BMI. Results: A novel SNP, downstream from the FAM120AOS gene on chromosome 9, was detected in the meta-analysis of ALSPAC and Raine. This association was driven by a difference in BMI at 8 years (T allele of rs944990 increased BMI; PSNP = 1.52 × 10−8), with a modest association with change in BMI over time (PWald(Change) = 0.006). Three known adult BMI-associated loci (FTO, MC4R and ADCY3) and one childhood obesity locus (OLFM4) reached genome-wide significance (PWald < 1.13 × 10−8) with BMI at 8 years and/or change over time. Conclusions: This GWAS of BMI trajectories over childhood identified a novel locus that warrants further investigation. We also observed genome-wide significance with previously established obesity loci, making the novel observation that these loci affected both the level and the rate of change in BMI. We have demonstrated that the use of repeated measures data can increase power to allow detection of genetic loci with smaller sample sizes. |
format |
Article in Journal/Newspaper |
author |
Warrington, NM Howe, LD Paternoster, L Kaakinen, M Herrala, S Huikari, V Wu, YY Kemp, JP Timpson, NJ St Pourcain, B Smith, GD Tilling, K Jarvelin, M-R Pennell, CE Evans, DM Lawlor, DA Briollais, L Palmer, LJ |
author_facet |
Warrington, NM Howe, LD Paternoster, L Kaakinen, M Herrala, S Huikari, V Wu, YY Kemp, JP Timpson, NJ St Pourcain, B Smith, GD Tilling, K Jarvelin, M-R Pennell, CE Evans, DM Lawlor, DA Briollais, L Palmer, LJ |
author_sort |
Warrington, NM |
title |
A genome-wide association study of body mass index across early life and childhood |
title_short |
A genome-wide association study of body mass index across early life and childhood |
title_full |
A genome-wide association study of body mass index across early life and childhood |
title_fullStr |
A genome-wide association study of body mass index across early life and childhood |
title_full_unstemmed |
A genome-wide association study of body mass index across early life and childhood |
title_sort |
genome-wide association study of body mass index across early life and childhood |
publisher |
Oxford University Press (OUP): Policy B - Oxford Open Option D |
publishDate |
2015 |
url |
http://hdl.handle.net/10044/1/48221 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357106100032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 https://doi.org/10.1093/ije/dyv077 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
712 700 |
op_relation |
International Journal of Epidemiology |
op_rights |
© 2015 The Author all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/ije/dyv077 |
container_title |
International Journal of Epidemiology |
container_volume |
44 |
container_issue |
2 |
container_start_page |
700 |
op_container_end_page |
712 |
_version_ |
1766144848588439552 |