Cardiometabolic risk factors in young ddults who were born preterm
Adults who were born preterm with a very low birth weight have higher blood pressure and impaired glucose regulation later in life compared with those born at term. We investigated cardiometabolic risk factors in young adults who were born at any degree of prematurity in the Preterm Birth and Early...
Published in: | American Journal of Epidemiology |
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Oxford University Press (OUP)
2014
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Online Access: | http://hdl.handle.net/10044/1/42455 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356180300005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 https://doi.org/10.1093/aje/kwu443 |
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ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/42455 2023-05-15T17:42:55+02:00 Cardiometabolic risk factors in young ddults who were born preterm Sipola-Leppanen, M Vaarasmaki, M Tikanmaki, M Matinolli, H-M Miettola, S Hovi, P Wehkalampi, K Ruokonen, A Sundvall, J Pouta, A Eriksson, JG Jarvelin, M-R Kajantie, E 2014-12-09 http://hdl.handle.net/10044/1/42455 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356180300005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 https://doi.org/10.1093/aje/kwu443 English eng Oxford University Press (OUP) American Journal of Epidemiology © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY 873 861 Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health blood pressure glucose metabolism hypertension late preterm obesity prematurity LOW-BIRTH-WEIGHT DENSITY-LIPOPROTEIN CHOLESTEROL SYSTOLIC BLOOD-PRESSURE CARDIOVASCULAR RISK SYSTEMATIC ANALYSIS GENERAL-POPULATION VASCULAR MORTALITY METABOLIC SYNDROME INDIVIDUAL DATA FETAL-GROWTH Adult Blood Glucose Body Weights and Measures Female Finland Gestational Age Humans Infant Newborn Insulin Resistance Lipids Male Metabolic Syndrome X Premature Birth Risk Factors Epidemiology 11 Medical And Health Sciences 01 Mathematical Sciences Journal Article 2014 ftimperialcol https://doi.org/10.1093/aje/kwu443 2018-09-16T05:57:36Z Adults who were born preterm with a very low birth weight have higher blood pressure and impaired glucose regulation later in life compared with those born at term. We investigated cardiometabolic risk factors in young adults who were born at any degree of prematurity in the Preterm Birth and Early Life Programming of Adult Health and Disease (ESTER) Study, a population-based cohort study of individuals born in 1985–1989 in Northern Finland. In 2009–2011, 3 groups underwent clinical examination: 134 participants born at less than 34 gestational weeks (early preterm), 242 born at 34–36 weeks (late preterm), and 344 born at 37 weeks or later (controls). Compared with controls, adults who were born preterm had higher body fat percentages (after adjustment for sex, age, and cohort (1985–1986 or 1987–1989), for those born early preterm, difference = 6.2%, 95% confidence interval (CI): 0.4, 13.2; for those born late preterm, difference = 8.0%, 95% CI: 2.4, 13.8), waist circumferences, blood pressure (for those born early preterm, difference = 3.0 mm Hg, 95% CI: 0.9, 5.1; for those born late preterm, difference = 1.7, 95% CI: −0.1, 3.4), plasma uric acid levels (for those born early preterm, difference = 20.1%, 95% CI: 7.9, 32.3; for those born late preterm, difference = 20.2%, 95% CI: 10.7, 30.5), alanine aminotransferase levels, and aspartate transaminase levels. They were also more likely to have metabolic syndrome (for those born early preterm, odds ratio = 3.7, 95% CI: 1.6, 8.2; for those born late preterm, odds ratio = 2.5, 95% CI: 1.2, 5.3). Elevated levels of conventional and emerging risk factors suggest a higher risk of cardiometabolic disease later in life. These risk factors are also present in the large group of adults born late preterm. Article in Journal/Newspaper Northern Finland Imperial College London: Spiral American Journal of Epidemiology 181 11 861 873 |
institution |
Open Polar |
collection |
Imperial College London: Spiral |
op_collection_id |
ftimperialcol |
language |
English |
topic |
Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health blood pressure glucose metabolism hypertension late preterm obesity prematurity LOW-BIRTH-WEIGHT DENSITY-LIPOPROTEIN CHOLESTEROL SYSTOLIC BLOOD-PRESSURE CARDIOVASCULAR RISK SYSTEMATIC ANALYSIS GENERAL-POPULATION VASCULAR MORTALITY METABOLIC SYNDROME INDIVIDUAL DATA FETAL-GROWTH Adult Blood Glucose Body Weights and Measures Female Finland Gestational Age Humans Infant Newborn Insulin Resistance Lipids Male Metabolic Syndrome X Premature Birth Risk Factors Epidemiology 11 Medical And Health Sciences 01 Mathematical Sciences |
spellingShingle |
Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health blood pressure glucose metabolism hypertension late preterm obesity prematurity LOW-BIRTH-WEIGHT DENSITY-LIPOPROTEIN CHOLESTEROL SYSTOLIC BLOOD-PRESSURE CARDIOVASCULAR RISK SYSTEMATIC ANALYSIS GENERAL-POPULATION VASCULAR MORTALITY METABOLIC SYNDROME INDIVIDUAL DATA FETAL-GROWTH Adult Blood Glucose Body Weights and Measures Female Finland Gestational Age Humans Infant Newborn Insulin Resistance Lipids Male Metabolic Syndrome X Premature Birth Risk Factors Epidemiology 11 Medical And Health Sciences 01 Mathematical Sciences Sipola-Leppanen, M Vaarasmaki, M Tikanmaki, M Matinolli, H-M Miettola, S Hovi, P Wehkalampi, K Ruokonen, A Sundvall, J Pouta, A Eriksson, JG Jarvelin, M-R Kajantie, E Cardiometabolic risk factors in young ddults who were born preterm |
topic_facet |
Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health blood pressure glucose metabolism hypertension late preterm obesity prematurity LOW-BIRTH-WEIGHT DENSITY-LIPOPROTEIN CHOLESTEROL SYSTOLIC BLOOD-PRESSURE CARDIOVASCULAR RISK SYSTEMATIC ANALYSIS GENERAL-POPULATION VASCULAR MORTALITY METABOLIC SYNDROME INDIVIDUAL DATA FETAL-GROWTH Adult Blood Glucose Body Weights and Measures Female Finland Gestational Age Humans Infant Newborn Insulin Resistance Lipids Male Metabolic Syndrome X Premature Birth Risk Factors Epidemiology 11 Medical And Health Sciences 01 Mathematical Sciences |
description |
Adults who were born preterm with a very low birth weight have higher blood pressure and impaired glucose regulation later in life compared with those born at term. We investigated cardiometabolic risk factors in young adults who were born at any degree of prematurity in the Preterm Birth and Early Life Programming of Adult Health and Disease (ESTER) Study, a population-based cohort study of individuals born in 1985–1989 in Northern Finland. In 2009–2011, 3 groups underwent clinical examination: 134 participants born at less than 34 gestational weeks (early preterm), 242 born at 34–36 weeks (late preterm), and 344 born at 37 weeks or later (controls). Compared with controls, adults who were born preterm had higher body fat percentages (after adjustment for sex, age, and cohort (1985–1986 or 1987–1989), for those born early preterm, difference = 6.2%, 95% confidence interval (CI): 0.4, 13.2; for those born late preterm, difference = 8.0%, 95% CI: 2.4, 13.8), waist circumferences, blood pressure (for those born early preterm, difference = 3.0 mm Hg, 95% CI: 0.9, 5.1; for those born late preterm, difference = 1.7, 95% CI: −0.1, 3.4), plasma uric acid levels (for those born early preterm, difference = 20.1%, 95% CI: 7.9, 32.3; for those born late preterm, difference = 20.2%, 95% CI: 10.7, 30.5), alanine aminotransferase levels, and aspartate transaminase levels. They were also more likely to have metabolic syndrome (for those born early preterm, odds ratio = 3.7, 95% CI: 1.6, 8.2; for those born late preterm, odds ratio = 2.5, 95% CI: 1.2, 5.3). Elevated levels of conventional and emerging risk factors suggest a higher risk of cardiometabolic disease later in life. These risk factors are also present in the large group of adults born late preterm. |
format |
Article in Journal/Newspaper |
author |
Sipola-Leppanen, M Vaarasmaki, M Tikanmaki, M Matinolli, H-M Miettola, S Hovi, P Wehkalampi, K Ruokonen, A Sundvall, J Pouta, A Eriksson, JG Jarvelin, M-R Kajantie, E |
author_facet |
Sipola-Leppanen, M Vaarasmaki, M Tikanmaki, M Matinolli, H-M Miettola, S Hovi, P Wehkalampi, K Ruokonen, A Sundvall, J Pouta, A Eriksson, JG Jarvelin, M-R Kajantie, E |
author_sort |
Sipola-Leppanen, M |
title |
Cardiometabolic risk factors in young ddults who were born preterm |
title_short |
Cardiometabolic risk factors in young ddults who were born preterm |
title_full |
Cardiometabolic risk factors in young ddults who were born preterm |
title_fullStr |
Cardiometabolic risk factors in young ddults who were born preterm |
title_full_unstemmed |
Cardiometabolic risk factors in young ddults who were born preterm |
title_sort |
cardiometabolic risk factors in young ddults who were born preterm |
publisher |
Oxford University Press (OUP) |
publishDate |
2014 |
url |
http://hdl.handle.net/10044/1/42455 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356180300005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 https://doi.org/10.1093/aje/kwu443 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
873 861 |
op_relation |
American Journal of Epidemiology |
op_rights |
© The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/aje/kwu443 |
container_title |
American Journal of Epidemiology |
container_volume |
181 |
container_issue |
11 |
container_start_page |
861 |
op_container_end_page |
873 |
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1766144848368238592 |