25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966
Higher vitamin D status, lower adiposity, and longer telomere length are each reportedly associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between vitamin D status (measured by circulating 25-hydroxyvitamin D (25(OH)D) concentration), adipo...
Published in: | American Journal of Epidemiology |
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Online Access: | http://hdl.handle.net/10044/1/40397 https://doi.org/10.1093/aje/kwv203 |
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ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/40397 2023-05-15T17:42:15+02:00 25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966 Williams, DM Palaniswamy, S Sebert, S Buxton, JL Blakemore, AIF Hyppoenen, E Jarvelin, M-R Wellcome Trust 2015-07-28 http://hdl.handle.net/10044/1/40397 https://doi.org/10.1093/aje/kwv203 unknown Oxford University Press American Journal of Epidemiology © The Author 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY 198 191 Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health biological aging Northern Finland Birth Cohorts telomere length vitamin D VITAMIN-D STATUS BODY-MASS INDEX MENDELIAN RANDOMIZATION CARDIOVASCULAR-DISEASE D DEFICIENCY ASSOCIATION RISK METAANALYSIS WOMEN MORTALITY Adiposity Adult Body Mass Index C-Reactive Protein Cross-Sectional Studies Female Finland Humans Leukocytes Male Prospective Studies Telomere Homeostasis Epidemiology 11 Medical And Health Sciences 01 Mathematical Sciences Journal Article 2015 ftimperialcol https://doi.org/10.1093/aje/kwv203 2018-09-16T05:56:59Z Higher vitamin D status, lower adiposity, and longer telomere length are each reportedly associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between vitamin D status (measured by circulating 25-hydroxyvitamin D (25(OH)D) concentration), adiposity, and telomere length are not well established. We conducted a cross-sectional analysis of associations of 25(OH)D and body mass index (BMI; weight (kg)/height (m)2) with mean relative leukocyte telomere length (LTL) using data gathered on 5,096 participants from Northern Finland Birth Cohort 1966 at age 31 years (1997). 25(OH)D was not associated with LTL in either basic or confounder/mediator-adjusted models. BMI was inversely associated with LTL after adjustment for potential confounding by age, sex, socioeconomic position, physical activity, diet, smoking, alcohol intake, and use of oral contraceptives (per 1-unit increase in BMI, mean difference in LTL = −0.4%, 95% confidence interval: −0.6, −0.2). The BMI-LTL association was also independent of 25(OH)D and was attenuated slightly, but remained, after adjustment for C-reactive protein, a marker of low-grade inflammation (mean difference in LTL = −0.3%, 95% confidence interval −0.6, −0.1). These findings suggest that vitamin D status is unlikely to be an important determinant of LTL, at least by young adulthood. Inflammation may partly mediate associations of adiposity with LTL. Article in Journal/Newspaper Northern Finland Imperial College London: Spiral American Journal of Epidemiology 183 3 191 198 |
institution |
Open Polar |
collection |
Imperial College London: Spiral |
op_collection_id |
ftimperialcol |
language |
unknown |
topic |
Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health biological aging Northern Finland Birth Cohorts telomere length vitamin D VITAMIN-D STATUS BODY-MASS INDEX MENDELIAN RANDOMIZATION CARDIOVASCULAR-DISEASE D DEFICIENCY ASSOCIATION RISK METAANALYSIS WOMEN MORTALITY Adiposity Adult Body Mass Index C-Reactive Protein Cross-Sectional Studies Female Finland Humans Leukocytes Male Prospective Studies Telomere Homeostasis Epidemiology 11 Medical And Health Sciences 01 Mathematical Sciences |
spellingShingle |
Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health biological aging Northern Finland Birth Cohorts telomere length vitamin D VITAMIN-D STATUS BODY-MASS INDEX MENDELIAN RANDOMIZATION CARDIOVASCULAR-DISEASE D DEFICIENCY ASSOCIATION RISK METAANALYSIS WOMEN MORTALITY Adiposity Adult Body Mass Index C-Reactive Protein Cross-Sectional Studies Female Finland Humans Leukocytes Male Prospective Studies Telomere Homeostasis Epidemiology 11 Medical And Health Sciences 01 Mathematical Sciences Williams, DM Palaniswamy, S Sebert, S Buxton, JL Blakemore, AIF Hyppoenen, E Jarvelin, M-R 25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966 |
topic_facet |
Science & Technology Life Sciences & Biomedicine Public Environmental & Occupational Health biological aging Northern Finland Birth Cohorts telomere length vitamin D VITAMIN-D STATUS BODY-MASS INDEX MENDELIAN RANDOMIZATION CARDIOVASCULAR-DISEASE D DEFICIENCY ASSOCIATION RISK METAANALYSIS WOMEN MORTALITY Adiposity Adult Body Mass Index C-Reactive Protein Cross-Sectional Studies Female Finland Humans Leukocytes Male Prospective Studies Telomere Homeostasis Epidemiology 11 Medical And Health Sciences 01 Mathematical Sciences |
description |
Higher vitamin D status, lower adiposity, and longer telomere length are each reportedly associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between vitamin D status (measured by circulating 25-hydroxyvitamin D (25(OH)D) concentration), adiposity, and telomere length are not well established. We conducted a cross-sectional analysis of associations of 25(OH)D and body mass index (BMI; weight (kg)/height (m)2) with mean relative leukocyte telomere length (LTL) using data gathered on 5,096 participants from Northern Finland Birth Cohort 1966 at age 31 years (1997). 25(OH)D was not associated with LTL in either basic or confounder/mediator-adjusted models. BMI was inversely associated with LTL after adjustment for potential confounding by age, sex, socioeconomic position, physical activity, diet, smoking, alcohol intake, and use of oral contraceptives (per 1-unit increase in BMI, mean difference in LTL = −0.4%, 95% confidence interval: −0.6, −0.2). The BMI-LTL association was also independent of 25(OH)D and was attenuated slightly, but remained, after adjustment for C-reactive protein, a marker of low-grade inflammation (mean difference in LTL = −0.3%, 95% confidence interval −0.6, −0.1). These findings suggest that vitamin D status is unlikely to be an important determinant of LTL, at least by young adulthood. Inflammation may partly mediate associations of adiposity with LTL. |
author2 |
Wellcome Trust |
format |
Article in Journal/Newspaper |
author |
Williams, DM Palaniswamy, S Sebert, S Buxton, JL Blakemore, AIF Hyppoenen, E Jarvelin, M-R |
author_facet |
Williams, DM Palaniswamy, S Sebert, S Buxton, JL Blakemore, AIF Hyppoenen, E Jarvelin, M-R |
author_sort |
Williams, DM |
title |
25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966 |
title_short |
25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966 |
title_full |
25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966 |
title_fullStr |
25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966 |
title_full_unstemmed |
25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966 |
title_sort |
25-hydroxyvitamin d concentration and leukocyte telomere length in young adults: findings from the northern finland birth cohort 1966 |
publisher |
Oxford University Press |
publishDate |
2015 |
url |
http://hdl.handle.net/10044/1/40397 https://doi.org/10.1093/aje/kwv203 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
198 191 |
op_relation |
American Journal of Epidemiology |
op_rights |
© The Author 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/aje/kwv203 |
container_title |
American Journal of Epidemiology |
container_volume |
183 |
container_issue |
3 |
container_start_page |
191 |
op_container_end_page |
198 |
_version_ |
1766144091602550784 |