Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug
Shikimic acid, more commonly known by its anionic form, shikimate, is an important intermediate compound of the ‘shikimate pathway’ in plants and microorganisms1. It is the principal precursor for the synthesis of aromatic amino acids, phenylalanine, tryptophan and tyrosine and other compounds such...
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2009
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ftiiscindia:oai:eprints.iisc.ernet.in:26104 2023-05-15T15:34:22+02:00 Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug Raghavendra, TR Vaidyanathan, Priti Swathi, HK Ramesha, BT Ravikanth, G Ganeshaiah, KN Srikrishna, A Shaanker, R Uma 2009 application/pdf http://eprints.iisc.ernet.in/26104/ http://eprints.iisc.ernet.in/26104/1/771.pdf http://www.ias.ac.in/currsci/mar252009/contents.htm unknown Indian Academy of Sciences. http://eprints.iisc.ernet.in/26104/1/771.pdf Raghavendra, TR and Vaidyanathan, Priti and Swathi, HK and Ramesha, BT and Ravikanth, G and Ganeshaiah, KN and Srikrishna, A and Shaanker, R Uma (2009) Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug. In: Current Science, 96 (6). pp. 771-772. Organic Chemistry Journal Article PeerReviewed 2009 ftiiscindia 2014-09-27T17:47:04Z Shikimic acid, more commonly known by its anionic form, shikimate, is an important intermediate compound of the ‘shikimate pathway’ in plants and microorganisms1. It is the principal precursor for the synthesis of aromatic amino acids, phenylalanine, tryptophan and tyrosine and other compounds such as alkaloids, phenolics and phenyl propanoids2. It is used extensively as a chiral building block for the synthesis of a number of compounds in both pharmaceutical and cosmetic industries3. In the recent past, the focus on shikimic acid has increased since it is the key precursor for the synthesis of Tamiflu, the only drug against avian flu caused by the H5N1 virus4,5. Shikimic acid is converted to a diethyl ketal intermediate, which is then reduced in two steps to an epoxide that is finally transformed to Tamiflu6. Article in Journal/Newspaper Avian flu Indian Institute of Science, Bangalore: ePrints@IIsc Ketal ENVELOPE(146.729,146.729,59.557,59.557) |
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Indian Institute of Science, Bangalore: ePrints@IIsc |
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ftiiscindia |
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topic |
Organic Chemistry |
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Organic Chemistry Raghavendra, TR Vaidyanathan, Priti Swathi, HK Ramesha, BT Ravikanth, G Ganeshaiah, KN Srikrishna, A Shaanker, R Uma Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug |
topic_facet |
Organic Chemistry |
description |
Shikimic acid, more commonly known by its anionic form, shikimate, is an important intermediate compound of the ‘shikimate pathway’ in plants and microorganisms1. It is the principal precursor for the synthesis of aromatic amino acids, phenylalanine, tryptophan and tyrosine and other compounds such as alkaloids, phenolics and phenyl propanoids2. It is used extensively as a chiral building block for the synthesis of a number of compounds in both pharmaceutical and cosmetic industries3. In the recent past, the focus on shikimic acid has increased since it is the key precursor for the synthesis of Tamiflu, the only drug against avian flu caused by the H5N1 virus4,5. Shikimic acid is converted to a diethyl ketal intermediate, which is then reduced in two steps to an epoxide that is finally transformed to Tamiflu6. |
format |
Article in Journal/Newspaper |
author |
Raghavendra, TR Vaidyanathan, Priti Swathi, HK Ramesha, BT Ravikanth, G Ganeshaiah, KN Srikrishna, A Shaanker, R Uma |
author_facet |
Raghavendra, TR Vaidyanathan, Priti Swathi, HK Ramesha, BT Ravikanth, G Ganeshaiah, KN Srikrishna, A Shaanker, R Uma |
author_sort |
Raghavendra, TR |
title |
Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug |
title_short |
Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug |
title_full |
Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug |
title_fullStr |
Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug |
title_full_unstemmed |
Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug |
title_sort |
prospecting for alternate sources of shikimic acid, a precursor of tamiflu, a bird-flu drug |
publisher |
Indian Academy of Sciences. |
publishDate |
2009 |
url |
http://eprints.iisc.ernet.in/26104/ http://eprints.iisc.ernet.in/26104/1/771.pdf http://www.ias.ac.in/currsci/mar252009/contents.htm |
long_lat |
ENVELOPE(146.729,146.729,59.557,59.557) |
geographic |
Ketal |
geographic_facet |
Ketal |
genre |
Avian flu |
genre_facet |
Avian flu |
op_relation |
http://eprints.iisc.ernet.in/26104/1/771.pdf Raghavendra, TR and Vaidyanathan, Priti and Swathi, HK and Ramesha, BT and Ravikanth, G and Ganeshaiah, KN and Srikrishna, A and Shaanker, R Uma (2009) Prospecting for alternate sources of shikimic acid, a precursor of Tamiflu, a bird-flu drug. In: Current Science, 96 (6). pp. 771-772. |
_version_ |
1766364793255493632 |