Structure based discovery of small molecule suppressors targeting bacterial lysozyme inhibitors

• Published in: Biochemical and Biophysical Research Communications
• Main Authors: Voet, Arnout, Callewaert, Lien, Ulens, Tim, Vanderkelen, Lise, Van Herreweghe, Joris, Michiels, Chris W., De Maeyer, Marc
• Format: Article in Journal/Newspaper
• Language: English
• Published: Academic Press 2011
• Subjects: Science & Technology; Life Sciences & Biomedicine; Biochemistry & Molecular Biology; Biophysics; Salmonella; PliC; MliC; Pharmacophore; Docking; Drug design; SMPPII; PROTEIN-PROTEIN INTERACTIONS; GRAM-NEGATIVE BACTERIA; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; EGG-WHITE; PEPTIDOGLYCAN; IVY; RECOGNITION; SPECIFICITY; RESISTANCE; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Computer Simulation; Drug Discovery; Models; Molecular; Molecular Sequence Data; Muramidase; Protein Conformation; Recombinant Proteins; Salmonella typhimurium; 0304 Medicinal and Biomolecular Chemistry; 0601 Biochemistry and Cell Biology; 1101 Medical Biochemistry and Metabolomics; 3101 Biochemistry and cell biology; 3404 Medicinal and biomolecular chemistry; Norway; Tromso
• Online Access: https://lirias.kuleuven.be/handle/123456789/299466; https://doi.org/10.1016/j.bbrc.2011.01.053; https://pubmed.ncbi.nlm.nih.gov/21256115

The production of lysozyme inhibitors, competitively binding to the lysozyme active site, is a bacterial strategy to prevent the lytic activity of host lysozymes. Therefore, suppression of the lysozyme-inhibitor interaction is an interesting new approach for drug development since restoration of the...