Evolution of Th1 and Th2 biased cytokines in divergent species of animals
Proteins or peptides that play a major role in immune as well as inflammatory responses via activation and regulation of other cells and tissues are known as cytokines. Their role in mammals is well defined, with a vast number of publications describing the structure of cytokines and their role in h...
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fticar:oai:ojs3.epubs.icar.org.in:article/93018 2023-05-15T15:50:17+02:00 Evolution of Th1 and Th2 biased cytokines in divergent species of animals KAUR, MANMEET MUKHOPADHYAY, CHANDRA SEKHAR ARORA, JASPREET SINGH DHANOA, JASDEEP KAUR 2019-08-26 application/pdf https://epubs.icar.org.in/index.php/IJAnS/article/view/93018 eng eng Directorate of Knowledge Management in Agriculture https://epubs.icar.org.in/index.php/IJAnS/article/view/93018/37549 https://epubs.icar.org.in/index.php/IJAnS/article/view/93018 Copyright (c) 2019 The Indian Journal of Animal Sciences The Indian Journal of Animal Sciences; Vol. 89 No. 8 (2019); 858–860 2394-3327 0367-8318 Bioinformatics Cytokines Divergent Evolution Phylogeny Species Th1 Th2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2019 fticar 2023-01-18T14:38:21Z Proteins or peptides that play a major role in immune as well as inflammatory responses via activation and regulation of other cells and tissues are known as cytokines. Their role in mammals is well defined, with a vast number of publications describing the structure of cytokines and their role in health and disease. Total 22 full-length CDS (and corresponding peptide) of the domains were selected as representatives of each type of cytokine, belonging to divergent animal species, for the biocomputational analysis. The secondary and tertiary structure of the different cytokine (peptide sequence) domains was predicted to compare the relatedness among the domains under study. Multiple sequence alignment and phylogenetic tree results indicated that IFN-gamma formed separate clusters for mammals, avian, and fish. In IL12, all were dispersed except Canis lupus and Sus scrofa. In IL13, chicken was completely dispersed from mammals and closely related to IL8 and TNF. These interleukins could have evolved independently from the respective ancestral sequences. Article in Journal/Newspaper Canis lupus Indian Agricultural Research Journals ( Indian Council of Agricultural Research) |
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Open Polar |
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Indian Agricultural Research Journals ( Indian Council of Agricultural Research) |
op_collection_id |
fticar |
language |
English |
topic |
Bioinformatics Cytokines Divergent Evolution Phylogeny Species Th1 Th2 |
spellingShingle |
Bioinformatics Cytokines Divergent Evolution Phylogeny Species Th1 Th2 KAUR, MANMEET MUKHOPADHYAY, CHANDRA SEKHAR ARORA, JASPREET SINGH DHANOA, JASDEEP KAUR Evolution of Th1 and Th2 biased cytokines in divergent species of animals |
topic_facet |
Bioinformatics Cytokines Divergent Evolution Phylogeny Species Th1 Th2 |
description |
Proteins or peptides that play a major role in immune as well as inflammatory responses via activation and regulation of other cells and tissues are known as cytokines. Their role in mammals is well defined, with a vast number of publications describing the structure of cytokines and their role in health and disease. Total 22 full-length CDS (and corresponding peptide) of the domains were selected as representatives of each type of cytokine, belonging to divergent animal species, for the biocomputational analysis. The secondary and tertiary structure of the different cytokine (peptide sequence) domains was predicted to compare the relatedness among the domains under study. Multiple sequence alignment and phylogenetic tree results indicated that IFN-gamma formed separate clusters for mammals, avian, and fish. In IL12, all were dispersed except Canis lupus and Sus scrofa. In IL13, chicken was completely dispersed from mammals and closely related to IL8 and TNF. These interleukins could have evolved independently from the respective ancestral sequences. |
format |
Article in Journal/Newspaper |
author |
KAUR, MANMEET MUKHOPADHYAY, CHANDRA SEKHAR ARORA, JASPREET SINGH DHANOA, JASDEEP KAUR |
author_facet |
KAUR, MANMEET MUKHOPADHYAY, CHANDRA SEKHAR ARORA, JASPREET SINGH DHANOA, JASDEEP KAUR |
author_sort |
KAUR, MANMEET |
title |
Evolution of Th1 and Th2 biased cytokines in divergent species of animals |
title_short |
Evolution of Th1 and Th2 biased cytokines in divergent species of animals |
title_full |
Evolution of Th1 and Th2 biased cytokines in divergent species of animals |
title_fullStr |
Evolution of Th1 and Th2 biased cytokines in divergent species of animals |
title_full_unstemmed |
Evolution of Th1 and Th2 biased cytokines in divergent species of animals |
title_sort |
evolution of th1 and th2 biased cytokines in divergent species of animals |
publisher |
Directorate of Knowledge Management in Agriculture |
publishDate |
2019 |
url |
https://epubs.icar.org.in/index.php/IJAnS/article/view/93018 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
The Indian Journal of Animal Sciences; Vol. 89 No. 8 (2019); 858–860 2394-3327 0367-8318 |
op_relation |
https://epubs.icar.org.in/index.php/IJAnS/article/view/93018/37549 https://epubs.icar.org.in/index.php/IJAnS/article/view/93018 |
op_rights |
Copyright (c) 2019 The Indian Journal of Animal Sciences |
_version_ |
1766385254370639872 |