Evolutionary relationships of Ljungan virus variants circulating in multi-host systems across Europe
The picornavirus named ‘Ljungan virus’ (LV, species Parechovirus B) has been detected in a dozen small mammal species from across Europe, but detailed information on its genetic diversity and host specificity is lacking. Here, we analyze the evolutionary relationships of LV variants circulating in f...
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Online Access: | http://hdl.handle.net/10449/69472 https://doi.org/10.3390/v13071317 |
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ftiasma:oai:openpub.fmach.it:10449/69472 2024-04-21T08:06:59+00:00 Evolutionary relationships of Ljungan virus variants circulating in multi-host systems across Europe Rossi, Chiara Zadra, Nicola Fevola, Cristina Ecke, Frauke Hörnfeldt, Birger Kallies, René Kazimirova, Maria Magnusson, Magnus Olsson, Gert E. Ulrich, Rainer G. Jääskeläinen, Anne J. Henttonen, Heikki Hauffe, Heidi C. Rossi, C. Zadra, N. Fevola, C. Ecke, F. Hörnfeldt, B. Kallies, R. Kazimirova, M. Magnusson, M. Olsson, G.E. Ulrich, R.G. Jääskeläinen, A.J. Henttonen, H. Hauffe, H.C. 2021 Elettronico/Electronic http://hdl.handle.net/10449/69472 https://doi.org/10.3390/v13071317 eng eng country:CH info:eu-repo/semantics/altIdentifier/wos/WOS:000677027800001 volume:13 issue:7 journal:VIRUSES info:eu-repo/grantAgreement/EC/FP7/261504 http://hdl.handle.net/10449/69472 doi:10.3390/v13071317 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85110722423 info:eu-repo/semantics/openAccess Picornaviridae Parechovirus B Ljungan virus Small mammals Rodent-borne virus Zoonosis Bank vole Settore BIO/05 - ZOOLOGIA info:eu-repo/semantics/article 2021 ftiasma https://doi.org/10.3390/v13071317 2024-03-27T17:49:46Z The picornavirus named ‘Ljungan virus’ (LV, species Parechovirus B) has been detected in a dozen small mammal species from across Europe, but detailed information on its genetic diversity and host specificity is lacking. Here, we analyze the evolutionary relationships of LV variants circulating in free-living mammal populations by comparing the phylogenetics of the VP1 region (encoding the capsid protein and associated with LV serotype) and the 3Dpol region (encoding the RNA polymerase) from 24 LV RNA-positive animals and a fragment of the 5′ untranslated region (UTR) sequence (used for defining strains) in sympatric small mammals. We define three new VP1 genotypes: two in bank voles (Myodes glareolus) (genotype 8 from Finland, Sweden, France, and Italy, and genotype 9 from France and Italy) and one in field voles (Microtus arvalis) (genotype 7 from Finland). There are several other indications that LV variants are host-specific, at least in parts of their range. Our results suggest that LV evolution is rapid, ongoing and affected by genetic drift, purifying selection, spillover and host evolutionary history. Although recent studies suggest that LV does not have zoonotic potential, its widespread geographical and host distribution in natural populations of well-characterized small mammals could make it useful as a model for studying RNA virus evolution and transmission. Article in Journal/Newspaper Microtus arvalis Fondazione Edmund Mach: IRIS-OpenPub Viruses 13 7 1317 |
institution |
Open Polar |
collection |
Fondazione Edmund Mach: IRIS-OpenPub |
op_collection_id |
ftiasma |
language |
English |
topic |
Picornaviridae Parechovirus B Ljungan virus Small mammals Rodent-borne virus Zoonosis Bank vole Settore BIO/05 - ZOOLOGIA |
spellingShingle |
Picornaviridae Parechovirus B Ljungan virus Small mammals Rodent-borne virus Zoonosis Bank vole Settore BIO/05 - ZOOLOGIA Rossi, Chiara Zadra, Nicola Fevola, Cristina Ecke, Frauke Hörnfeldt, Birger Kallies, René Kazimirova, Maria Magnusson, Magnus Olsson, Gert E. Ulrich, Rainer G. Jääskeläinen, Anne J. Henttonen, Heikki Hauffe, Heidi C. Evolutionary relationships of Ljungan virus variants circulating in multi-host systems across Europe |
topic_facet |
Picornaviridae Parechovirus B Ljungan virus Small mammals Rodent-borne virus Zoonosis Bank vole Settore BIO/05 - ZOOLOGIA |
description |
The picornavirus named ‘Ljungan virus’ (LV, species Parechovirus B) has been detected in a dozen small mammal species from across Europe, but detailed information on its genetic diversity and host specificity is lacking. Here, we analyze the evolutionary relationships of LV variants circulating in free-living mammal populations by comparing the phylogenetics of the VP1 region (encoding the capsid protein and associated with LV serotype) and the 3Dpol region (encoding the RNA polymerase) from 24 LV RNA-positive animals and a fragment of the 5′ untranslated region (UTR) sequence (used for defining strains) in sympatric small mammals. We define three new VP1 genotypes: two in bank voles (Myodes glareolus) (genotype 8 from Finland, Sweden, France, and Italy, and genotype 9 from France and Italy) and one in field voles (Microtus arvalis) (genotype 7 from Finland). There are several other indications that LV variants are host-specific, at least in parts of their range. Our results suggest that LV evolution is rapid, ongoing and affected by genetic drift, purifying selection, spillover and host evolutionary history. Although recent studies suggest that LV does not have zoonotic potential, its widespread geographical and host distribution in natural populations of well-characterized small mammals could make it useful as a model for studying RNA virus evolution and transmission. |
author2 |
Rossi, C. Zadra, N. Fevola, C. Ecke, F. Hörnfeldt, B. Kallies, R. Kazimirova, M. Magnusson, M. Olsson, G.E. Ulrich, R.G. Jääskeläinen, A.J. Henttonen, H. Hauffe, H.C. |
format |
Article in Journal/Newspaper |
author |
Rossi, Chiara Zadra, Nicola Fevola, Cristina Ecke, Frauke Hörnfeldt, Birger Kallies, René Kazimirova, Maria Magnusson, Magnus Olsson, Gert E. Ulrich, Rainer G. Jääskeläinen, Anne J. Henttonen, Heikki Hauffe, Heidi C. |
author_facet |
Rossi, Chiara Zadra, Nicola Fevola, Cristina Ecke, Frauke Hörnfeldt, Birger Kallies, René Kazimirova, Maria Magnusson, Magnus Olsson, Gert E. Ulrich, Rainer G. Jääskeläinen, Anne J. Henttonen, Heikki Hauffe, Heidi C. |
author_sort |
Rossi, Chiara |
title |
Evolutionary relationships of Ljungan virus variants circulating in multi-host systems across Europe |
title_short |
Evolutionary relationships of Ljungan virus variants circulating in multi-host systems across Europe |
title_full |
Evolutionary relationships of Ljungan virus variants circulating in multi-host systems across Europe |
title_fullStr |
Evolutionary relationships of Ljungan virus variants circulating in multi-host systems across Europe |
title_full_unstemmed |
Evolutionary relationships of Ljungan virus variants circulating in multi-host systems across Europe |
title_sort |
evolutionary relationships of ljungan virus variants circulating in multi-host systems across europe |
publisher |
country:CH |
publishDate |
2021 |
url |
http://hdl.handle.net/10449/69472 https://doi.org/10.3390/v13071317 |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/WOS:000677027800001 volume:13 issue:7 journal:VIRUSES info:eu-repo/grantAgreement/EC/FP7/261504 http://hdl.handle.net/10449/69472 doi:10.3390/v13071317 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85110722423 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/v13071317 |
container_title |
Viruses |
container_volume |
13 |
container_issue |
7 |
container_start_page |
1317 |
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1796946518446440448 |