miRNAs Predicted to Regulate Host Anti-viral Gene Pathways in IPNV-Challenged Atlantic Salmon Fry Are Affected by Viral Load, and Associated With the Major IPN Resistance QTL Genotypes in Late Infection

• Published in: Frontiers in Immunology
• Main Authors: Woldemariam, Nardos Tesfaye, Agafonov, Aleksander, Sindre, Hilde, Høyheim, Bjørn, Andreassen, Rune
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Media 2020
• Subjects: Atlantic salmon; Ribonucleic acids; MicroRNAs; Infectious pancreatic necrosis viruses; IPNVs; Immune responses; Host-virus interactions; Ikka; Norway
• Online Access: https://hdl.handle.net/10642/9380; https://doi.org/10.3389/fimmu.2020.02113

Infectious pancreatic necrosis virus (IPNV) infection has been a major problem in salmonid aquaculture. Marker-assisted selection of individuals with resistant genotype at the major IPN quantitative trait locus (IPN-QTL) has significantly reduced mortality in recent years. We have identified host mi...