Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study
Mini-abstract: Low bone mineral density (BMD) gives an increased risk of fractures, which can lead to premature death. Can BMD of the wrist predict mortality? BMD consistent with osteopenia and osteoporosis gave a significantly increased risk of death for both men and women in a general population i...
Published in: | Osteoporosis International |
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Language: | English |
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Springer Verlag
2018
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Online Access: | https://hdl.handle.net/10642/6182 https://doi.org/10.1007/s00198-018-4653-z |
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fthsosloakersoda:oai:oda.oslomet.no:10642/6182 2023-05-15T18:34:20+02:00 Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Ståhle, Agneta Emaus, Nina Strand, Bjørn Heine 2018-08-15T08:47:30Z application/pdf https://hdl.handle.net/10642/6182 https://doi.org/10.1007/s00198-018-4653-z en eng Springer Verlag Osteoporosis International; Hauger AV, Bergland A, Holvik K, Ståhle A, Emaus N, Strand BH. Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study. Osteoporosis International. 2018 urn:issn:0937-941X urn:issn:1433-2965 https://hdl.handle.net/10642/6182 http://dx.doi.org/10.1007/s00198-018-4653-z cristin:1602122 The final publication is available at Springer via http://dx.doi.org/10.1007/s00198-018-4653-z Osteoporosis International Osteoporosis Osteopenia Bone mineral density Mortalitities Grip strength Hip fractures VDP::Medisinske fag: 700 VDP::Midical sciences: 700 Journal article Peer reviewed 2018 fthsosloakersoda https://doi.org/10.1007/s00198-018-4653-z 2021-10-11T16:53:47Z Mini-abstract: Low bone mineral density (BMD) gives an increased risk of fractures, which can lead to premature death. Can BMD of the wrist predict mortality? BMD consistent with osteopenia and osteoporosis gave a significantly increased risk of death for both men and women in a general population in Tromsø, Norway. Summary: Low bone mineral density (BMD) gives an increased risk of fractures, which can lead to premature death. Can BMD of the wrist predict mortality?BMD consistent With osteopenia and osteoporosis gave a significantly increased risk of death for both men and women in a general population in Tromsø, Norway. Purpose: To investigate if bone mineral density (BMD) levels of the distal forearm, consistent with osteopenia and osteoporosis, can predict mortality and if grip strength is an effect modifier. Methods: The study population constituted 6565 participants aged 50–79 years at baseline in the Tromsø Study wave conducted in 1994–1995. Forearm BMD measured by SXA was categorized as "normal", "osteopenia", or "osteoporosis" following WHO’s definition. Cox regression with all-cause mortality as the outcome over 22 years of follow-up was performed for men and women separately, adjusting for health-related factors, as well as BMD by grip strength interaction. A secondary analysis with a 15-year follow-up also adjusted for hip fractures and osteoporotic fractures. Results: During follow-up, 3176 of participants died (47%). Those categorized as osteoporotic had higher mortality hazard ratio (HR) compared to those with normal BMD; men HR=1.37 (95% confidence interval (CI) 1.19, 1.58) and women HR=1.32 (1.14,1.53)were adjusted for age, body mass index, physical activity, smoking habits, education, health status, chronic diseases, and grip strength. Corresponding HRs for osteopenia were men HR=1.13 (1.00, 1.27) and women HR=1.17 (1.01, 1.35). Further adjustments for fractures did only marginally attenuate the results, and HRs were still significant. There was no grip strength by BMD interaction. Conclusion: Men and women with low distal forearm BMD values, consistent with osteoporosis or osteopenia, had an increased mortality compared to normal BMD participants. High grip strength did not modify this association, and the association remained after adjustment for a range of health-related factors. acceptedVersion Article in Journal/Newspaper Tromsø OsloMet (Oslo Metropolitan University): ODA (Open Digital Archive) Norway Tromsø Osteoporosis International 29 11 2447 2456 |
institution |
Open Polar |
collection |
OsloMet (Oslo Metropolitan University): ODA (Open Digital Archive) |
op_collection_id |
fthsosloakersoda |
language |
English |
topic |
Osteoporosis Osteopenia Bone mineral density Mortalitities Grip strength Hip fractures VDP::Medisinske fag: 700 VDP::Midical sciences: 700 |
spellingShingle |
Osteoporosis Osteopenia Bone mineral density Mortalitities Grip strength Hip fractures VDP::Medisinske fag: 700 VDP::Midical sciences: 700 Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Ståhle, Agneta Emaus, Nina Strand, Bjørn Heine Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
topic_facet |
Osteoporosis Osteopenia Bone mineral density Mortalitities Grip strength Hip fractures VDP::Medisinske fag: 700 VDP::Midical sciences: 700 |
description |
Mini-abstract: Low bone mineral density (BMD) gives an increased risk of fractures, which can lead to premature death. Can BMD of the wrist predict mortality? BMD consistent with osteopenia and osteoporosis gave a significantly increased risk of death for both men and women in a general population in Tromsø, Norway. Summary: Low bone mineral density (BMD) gives an increased risk of fractures, which can lead to premature death. Can BMD of the wrist predict mortality?BMD consistent With osteopenia and osteoporosis gave a significantly increased risk of death for both men and women in a general population in Tromsø, Norway. Purpose: To investigate if bone mineral density (BMD) levels of the distal forearm, consistent with osteopenia and osteoporosis, can predict mortality and if grip strength is an effect modifier. Methods: The study population constituted 6565 participants aged 50–79 years at baseline in the Tromsø Study wave conducted in 1994–1995. Forearm BMD measured by SXA was categorized as "normal", "osteopenia", or "osteoporosis" following WHO’s definition. Cox regression with all-cause mortality as the outcome over 22 years of follow-up was performed for men and women separately, adjusting for health-related factors, as well as BMD by grip strength interaction. A secondary analysis with a 15-year follow-up also adjusted for hip fractures and osteoporotic fractures. Results: During follow-up, 3176 of participants died (47%). Those categorized as osteoporotic had higher mortality hazard ratio (HR) compared to those with normal BMD; men HR=1.37 (95% confidence interval (CI) 1.19, 1.58) and women HR=1.32 (1.14,1.53)were adjusted for age, body mass index, physical activity, smoking habits, education, health status, chronic diseases, and grip strength. Corresponding HRs for osteopenia were men HR=1.13 (1.00, 1.27) and women HR=1.17 (1.01, 1.35). Further adjustments for fractures did only marginally attenuate the results, and HRs were still significant. There was no grip strength by BMD interaction. Conclusion: Men and women with low distal forearm BMD values, consistent with osteoporosis or osteopenia, had an increased mortality compared to normal BMD participants. High grip strength did not modify this association, and the association remained after adjustment for a range of health-related factors. acceptedVersion |
format |
Article in Journal/Newspaper |
author |
Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Ståhle, Agneta Emaus, Nina Strand, Bjørn Heine |
author_facet |
Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Ståhle, Agneta Emaus, Nina Strand, Bjørn Heine |
author_sort |
Hauger, Annette Vogt |
title |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_short |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_full |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_fullStr |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_full_unstemmed |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_sort |
osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based tromsø study |
publisher |
Springer Verlag |
publishDate |
2018 |
url |
https://hdl.handle.net/10642/6182 https://doi.org/10.1007/s00198-018-4653-z |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Osteoporosis International |
op_relation |
Osteoporosis International; Hauger AV, Bergland A, Holvik K, Ståhle A, Emaus N, Strand BH. Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study. Osteoporosis International. 2018 urn:issn:0937-941X urn:issn:1433-2965 https://hdl.handle.net/10642/6182 http://dx.doi.org/10.1007/s00198-018-4653-z cristin:1602122 |
op_rights |
The final publication is available at Springer via http://dx.doi.org/10.1007/s00198-018-4653-z |
op_doi |
https://doi.org/10.1007/s00198-018-4653-z |
container_title |
Osteoporosis International |
container_volume |
29 |
container_issue |
11 |
container_start_page |
2447 |
op_container_end_page |
2456 |
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1766219042925838336 |