Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage
A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The assoc...
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fthsosloakersoda:oai:oda.oslomet.no:10642/5945 2023-05-15T14:59:15+02:00 Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage Malm, Gunilla Haugen, Trine B. Rylander, Lars Giwercman, Aleksander 2018-02-16T09:50:16Z application/pdf https://hdl.handle.net/10642/5945 https://doi.org/10.4103/1008-682X.186870 en eng Medknow Publications Asian Journal of Andrology;Volume 19, Issue 1 Malm G, Haugen TB, Rylander L, Giwercman A. Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage. Asian Journal of Andrology . 2017;19(1):52-56 urn:issn:1008-682X urn:issn:1745-7262 https://hdl.handle.net/10642/5945 http://dx.doi.org/10.4103/1008-682X.186870 cristin:1482458 Open Access Asian Journal of Andrology Male infertility Melatonin Semen quality Sperm DNA indexes Journal article Peer reviewed 2018 fthsosloakersoda https://doi.org/10.4103/1008-682X.186870 2023-04-05T22:38:11Z A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The association between the major melatonin metabolite, urine 6‑sulfatoxymelatonin (aMT6s), and DFI was analyzed in 110 Oslo men (south of the Arctic Circle) and 86 Tromsoe men (north of the Arctic Circle). Two semen analyses, summer and winter, and four urine samples (early/late summer; early/late winter), were analyzed. The associations between aMT6s in urine and DFI were characterized in a cross‑sectional and longitudinal manner using correlation analysis and linear regression. Regardless of season and location, no significant correlations between aMT6s and DFI were observed. The correlation coefficients for associations between changes over time (early winter–early summer) in aMT6s and DFI were for the total cohort: rho = −0.08 ( P = 0.322), for the Oslo cohort: rho = −0.07 ( P = 0.485), and for the Tromsoe cohort: rho = −0.14 ( P = 0.273), respectively. Similar results were seen when comparing late winter and late summer. There was no any statistically significant correlation between changes over time in aMT6s and DFI for men with DFI below and above the median value (10%), respectively. The seasonal variation in melatonin excretion seems not to have any impact on DFI. publishedVersion Article in Journal/Newspaper Arctic Tromsoe OsloMet (Oslo Metropolitan University): ODA (Open Digital Archive) Arctic Rho ENVELOPE(-63.000,-63.000,-64.300,-64.300) Asian Journal of Andrology 0 0 0 |
institution |
Open Polar |
collection |
OsloMet (Oslo Metropolitan University): ODA (Open Digital Archive) |
op_collection_id |
fthsosloakersoda |
language |
English |
topic |
Male infertility Melatonin Semen quality Sperm DNA indexes |
spellingShingle |
Male infertility Melatonin Semen quality Sperm DNA indexes Malm, Gunilla Haugen, Trine B. Rylander, Lars Giwercman, Aleksander Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
topic_facet |
Male infertility Melatonin Semen quality Sperm DNA indexes |
description |
A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The association between the major melatonin metabolite, urine 6‑sulfatoxymelatonin (aMT6s), and DFI was analyzed in 110 Oslo men (south of the Arctic Circle) and 86 Tromsoe men (north of the Arctic Circle). Two semen analyses, summer and winter, and four urine samples (early/late summer; early/late winter), were analyzed. The associations between aMT6s in urine and DFI were characterized in a cross‑sectional and longitudinal manner using correlation analysis and linear regression. Regardless of season and location, no significant correlations between aMT6s and DFI were observed. The correlation coefficients for associations between changes over time (early winter–early summer) in aMT6s and DFI were for the total cohort: rho = −0.08 ( P = 0.322), for the Oslo cohort: rho = −0.07 ( P = 0.485), and for the Tromsoe cohort: rho = −0.14 ( P = 0.273), respectively. Similar results were seen when comparing late winter and late summer. There was no any statistically significant correlation between changes over time in aMT6s and DFI for men with DFI below and above the median value (10%), respectively. The seasonal variation in melatonin excretion seems not to have any impact on DFI. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Malm, Gunilla Haugen, Trine B. Rylander, Lars Giwercman, Aleksander |
author_facet |
Malm, Gunilla Haugen, Trine B. Rylander, Lars Giwercman, Aleksander |
author_sort |
Malm, Gunilla |
title |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_short |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_full |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_fullStr |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_full_unstemmed |
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage |
title_sort |
seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm dna damage |
publisher |
Medknow Publications |
publishDate |
2018 |
url |
https://hdl.handle.net/10642/5945 https://doi.org/10.4103/1008-682X.186870 |
long_lat |
ENVELOPE(-63.000,-63.000,-64.300,-64.300) |
geographic |
Arctic Rho |
geographic_facet |
Arctic Rho |
genre |
Arctic Tromsoe |
genre_facet |
Arctic Tromsoe |
op_source |
Asian Journal of Andrology |
op_relation |
Asian Journal of Andrology;Volume 19, Issue 1 Malm G, Haugen TB, Rylander L, Giwercman A. Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage. Asian Journal of Andrology . 2017;19(1):52-56 urn:issn:1008-682X urn:issn:1745-7262 https://hdl.handle.net/10642/5945 http://dx.doi.org/10.4103/1008-682X.186870 cristin:1482458 |
op_rights |
Open Access |
op_doi |
https://doi.org/10.4103/1008-682X.186870 |
container_title |
Asian Journal of Andrology |
container_volume |
0 |
container_issue |
0 |
container_start_page |
0 |
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1766331364181803008 |