Hibernating brown bears are protected against atherogenic dyslipidemia
To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classes, trigly...
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fthsinnlandet:oai:brage.inn.no:11250/2994612 2024-03-03T08:49:18+00:00 Hibernating brown bears are protected against atherogenic dyslipidemia Giroud, Sylvain Chery, Isabelle Arrivé, Mathilde Prost, Michel Zumsteg, Julie Heintz, Dimitri Evans, Alina Gauquelin-Koch, Guillemette Arnemo, Jon Martin Swenson, Jon E. Lefai, Etienne Bertile, Fabrice Simon, Chantal Blanc, Stéphane 2021 application/pdf https://hdl.handle.net/11250/2994612 https://doi.org/10.1038/s41598-021-98085-7 eng eng Scientific Reports. 2021, 11 . urn:issn:2045-2322 https://hdl.handle.net/11250/2994612 https://doi.org/10.1038/s41598-021-98085-7 cristin:1942135 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no 16 11 Scientific Reports Brown bears Hibernation atherogenic dyslipidemia Peer reviewed Journal article 2021 fthsinnlandet https://doi.org/10.1038/s41598-021-98085-7 2024-02-02T12:42:11Z To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classes, triglyceride-related plasma-enzyme activities, and muscle lipid composition along with plasma-levels of antioxidant capacities and inflammatory markers. Although hibernating bears increased nearly all lipid levels, a 36%-higher cholesteryl-ester transfer-protein activity allowed to stabilize lipid composition of high-density lipoproteins (HDL). Levels of inflammatory metabolites, i.e., 7-ketocholesterol and 11ß-prostaglandin F2α, declined in winter and correlated inversely with cardioprotective HDL2b-proportions and HDL-sizes that increased during hibernation. Lower muscle cholesterol concentrations and lecithin-cholesterol acyltransferase activity in winter suggest that hibernating bears tightly controlled peripheral-cholesterol synthesis and/or release. Finally, greater plasma-antioxidant capacities prevented excessive lipid-specific oxidative damages in plasma and muscles of hibernating bears. Hence, the brown bear manages large lipid fluxes during hibernation, without developing adverse atherogenic effects that occur in humans and non-hibernators. publishedVersion Article in Journal/Newspaper Ursus arctos Høgskolen i Innlandet: Brage INN Scientific Reports 11 1 |
institution |
Open Polar |
collection |
Høgskolen i Innlandet: Brage INN |
op_collection_id |
fthsinnlandet |
language |
English |
topic |
Brown bears Hibernation atherogenic dyslipidemia |
spellingShingle |
Brown bears Hibernation atherogenic dyslipidemia Giroud, Sylvain Chery, Isabelle Arrivé, Mathilde Prost, Michel Zumsteg, Julie Heintz, Dimitri Evans, Alina Gauquelin-Koch, Guillemette Arnemo, Jon Martin Swenson, Jon E. Lefai, Etienne Bertile, Fabrice Simon, Chantal Blanc, Stéphane Hibernating brown bears are protected against atherogenic dyslipidemia |
topic_facet |
Brown bears Hibernation atherogenic dyslipidemia |
description |
To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classes, triglyceride-related plasma-enzyme activities, and muscle lipid composition along with plasma-levels of antioxidant capacities and inflammatory markers. Although hibernating bears increased nearly all lipid levels, a 36%-higher cholesteryl-ester transfer-protein activity allowed to stabilize lipid composition of high-density lipoproteins (HDL). Levels of inflammatory metabolites, i.e., 7-ketocholesterol and 11ß-prostaglandin F2α, declined in winter and correlated inversely with cardioprotective HDL2b-proportions and HDL-sizes that increased during hibernation. Lower muscle cholesterol concentrations and lecithin-cholesterol acyltransferase activity in winter suggest that hibernating bears tightly controlled peripheral-cholesterol synthesis and/or release. Finally, greater plasma-antioxidant capacities prevented excessive lipid-specific oxidative damages in plasma and muscles of hibernating bears. Hence, the brown bear manages large lipid fluxes during hibernation, without developing adverse atherogenic effects that occur in humans and non-hibernators. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Giroud, Sylvain Chery, Isabelle Arrivé, Mathilde Prost, Michel Zumsteg, Julie Heintz, Dimitri Evans, Alina Gauquelin-Koch, Guillemette Arnemo, Jon Martin Swenson, Jon E. Lefai, Etienne Bertile, Fabrice Simon, Chantal Blanc, Stéphane |
author_facet |
Giroud, Sylvain Chery, Isabelle Arrivé, Mathilde Prost, Michel Zumsteg, Julie Heintz, Dimitri Evans, Alina Gauquelin-Koch, Guillemette Arnemo, Jon Martin Swenson, Jon E. Lefai, Etienne Bertile, Fabrice Simon, Chantal Blanc, Stéphane |
author_sort |
Giroud, Sylvain |
title |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_short |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_full |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_fullStr |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_full_unstemmed |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_sort |
hibernating brown bears are protected against atherogenic dyslipidemia |
publishDate |
2021 |
url |
https://hdl.handle.net/11250/2994612 https://doi.org/10.1038/s41598-021-98085-7 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
16 11 Scientific Reports |
op_relation |
Scientific Reports. 2021, 11 . urn:issn:2045-2322 https://hdl.handle.net/11250/2994612 https://doi.org/10.1038/s41598-021-98085-7 cristin:1942135 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_doi |
https://doi.org/10.1038/s41598-021-98085-7 |
container_title |
Scientific Reports |
container_volume |
11 |
container_issue |
1 |
_version_ |
1792506489476218880 |