The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos
Hibernation is an adaptation that helps many animals to conserve energy during food shortage in winter. Brown bears double their fat depots during summer and use these stored lipids during hibernation. Although bears seasonally become obese, they remain metabolically healthy. We analyzed the microbi...
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Online Access: | http://hdl.handle.net/11250/2381158 https://doi.org/10.1016/j.celrep.2016.01.026 |
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fthsinnlandet:oai:brage.inn.no:11250/2381158 2024-03-03T08:49:18+00:00 The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos Sommer, Felix Ståhlman, Marcus Ilkayeva, Olga Arnemo, Jon Martin Kindberg, Jonas Josefsson, Johan Newgard, Christopher B Fröbert, Ole Bäckhed, Fredrik 2016 application/pdf http://hdl.handle.net/11250/2381158 https://doi.org/10.1016/j.celrep.2016.01.026 eng eng Cell press Sommer, F., Ståhlman, M., Ilkayeva, O., Arnemo, J. M., Kindberg, J., Josefsson, J., . . . Bäckhed, F. (2016). The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos. Cell reports, 14(7), 1655-1661. doi:10.1016/j.celrep.2016.01.026 http://hdl.handle.net/11250/2381158 https://doi.org/10.1016/j.celrep.2016.01.026 1655-1661 14 Cell reports 7 VDP::Mathematics and natural science: 400::Zoology and botany: 480 Journal article Peer reviewed 2016 fthsinnlandet https://doi.org/10.1016/j.celrep.2016.01.026 2024-02-02T12:42:31Z Hibernation is an adaptation that helps many animals to conserve energy during food shortage in winter. Brown bears double their fat depots during summer and use these stored lipids during hibernation. Although bears seasonally become obese, they remain metabolically healthy. We analyzed the microbiota of free-ranging brown bears during their active phase and hibernation. Compared to the active phase, hibernation microbiota had reduced diversity, reduced levels of Firmicutes and Actinobacteria, and increased levels of Bacteroidetes. Several metabolites involved in lipid metabolism, including triglycerides, cholesterol, and bile acids, were also affected by hibernation. Transplantation of the bear microbiota from summer and winter to germ-free mice transferred some of the seasonal metabolic features and demonstrated that the summer microbiota promoted adiposity without impairing glucose tolerance, suggesting that seasonal variation in the microbiota may contribute to host energy metabolism in the hibernating brown bear. Article in Journal/Newspaper Ursus arctos Høgskolen i Innlandet: Brage INN Cell Reports 14 7 1655 1661 |
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Høgskolen i Innlandet: Brage INN |
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language |
English |
topic |
VDP::Mathematics and natural science: 400::Zoology and botany: 480 |
spellingShingle |
VDP::Mathematics and natural science: 400::Zoology and botany: 480 Sommer, Felix Ståhlman, Marcus Ilkayeva, Olga Arnemo, Jon Martin Kindberg, Jonas Josefsson, Johan Newgard, Christopher B Fröbert, Ole Bäckhed, Fredrik The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
topic_facet |
VDP::Mathematics and natural science: 400::Zoology and botany: 480 |
description |
Hibernation is an adaptation that helps many animals to conserve energy during food shortage in winter. Brown bears double their fat depots during summer and use these stored lipids during hibernation. Although bears seasonally become obese, they remain metabolically healthy. We analyzed the microbiota of free-ranging brown bears during their active phase and hibernation. Compared to the active phase, hibernation microbiota had reduced diversity, reduced levels of Firmicutes and Actinobacteria, and increased levels of Bacteroidetes. Several metabolites involved in lipid metabolism, including triglycerides, cholesterol, and bile acids, were also affected by hibernation. Transplantation of the bear microbiota from summer and winter to germ-free mice transferred some of the seasonal metabolic features and demonstrated that the summer microbiota promoted adiposity without impairing glucose tolerance, suggesting that seasonal variation in the microbiota may contribute to host energy metabolism in the hibernating brown bear. |
format |
Article in Journal/Newspaper |
author |
Sommer, Felix Ståhlman, Marcus Ilkayeva, Olga Arnemo, Jon Martin Kindberg, Jonas Josefsson, Johan Newgard, Christopher B Fröbert, Ole Bäckhed, Fredrik |
author_facet |
Sommer, Felix Ståhlman, Marcus Ilkayeva, Olga Arnemo, Jon Martin Kindberg, Jonas Josefsson, Johan Newgard, Christopher B Fröbert, Ole Bäckhed, Fredrik |
author_sort |
Sommer, Felix |
title |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_short |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_full |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_fullStr |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_full_unstemmed |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_sort |
gut microbiota modulates energy metabolism in the hibernating brown bear ursus arctos |
publisher |
Cell press |
publishDate |
2016 |
url |
http://hdl.handle.net/11250/2381158 https://doi.org/10.1016/j.celrep.2016.01.026 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
1655-1661 14 Cell reports 7 |
op_relation |
Sommer, F., Ståhlman, M., Ilkayeva, O., Arnemo, J. M., Kindberg, J., Josefsson, J., . . . Bäckhed, F. (2016). The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos. Cell reports, 14(7), 1655-1661. doi:10.1016/j.celrep.2016.01.026 http://hdl.handle.net/11250/2381158 https://doi.org/10.1016/j.celrep.2016.01.026 |
op_doi |
https://doi.org/10.1016/j.celrep.2016.01.026 |
container_title |
Cell Reports |
container_volume |
14 |
container_issue |
7 |
container_start_page |
1655 |
op_container_end_page |
1661 |
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1792506488498946048 |