Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators?
Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals (<5kg), in which Tb generally drop drastically, display leukopenia during hibernation. This raised the question of whether the decreased leukocyte counts...
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Online Access: | http://hdl.handle.net/11250/134538 https://doi.org/10.7150/ijms.4476 |
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fthsinnlandet:oai:brage.inn.no:11250/134538 2024-03-03T08:42:17+00:00 Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? Sahdo, Berolla Evans, Alina L. Arnemo, Jon Martin Fröbert, Ole Särndahl, Eva Blanc, Stéphane 2013 application/pdf http://hdl.handle.net/11250/134538 https://doi.org/10.7150/ijms.4476 eng eng IVYSPRING http://www.medsci.org/v10p0508.htm Sahdo, B., Evans, A., Arnemo, J. M., Fröbert, O., Särndahl, E., & Blanc, S. (2013). Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? International Journal of Medical Sciences, 10(5), 508-514. doi: http://dx.doi.org/10.7150/ijms.4476 http://hdl.handle.net/11250/134538 https://doi.org/10.7150/ijms.4476 508-514 10 International Journal of Medical Sciences 5 brown bears ursus arctos hibernation innate immunity leukocytes torpor VDP::Mathematics and natural science: 400::Zoology and botany: 480 Journal article Peer reviewed 2013 fthsinnlandet https://doi.org/10.7150/ijms.4476 2024-02-02T12:42:28Z Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals (<5kg), in which Tb generally drop drastically, display leukopenia during hibernation. This raised the question of whether the decreased leukocyte counts in mammalian hibernators is due to torpor per se or is secondary to low Tb. The present study examined immune cell counts in brown bears (Ursus arctos), where torpor is only associated with shallow decreases in Tb. The results were compared across hibernator species for which immune and Tb data were available. Methods and Results: The white blood cell counts were determined by flow cytometry in 13 bears captured in the field both during summer and winter over 2 years time. Tb dropped from 39.6±0.8 to 33.5±1.1°C during hibernation. Blood neutrophils and monocytes were lower during hibernation than during the active period (47%, p= 0.001; 43%, p=0.039, respectively), whereas no change in lymphocyte counts was detected (p=0.599). Further, combining our data and those from 10 studies on 9 hibernating species suggested that the decline in Tb explained the decrease in innate immune cells (R2=0.83, p<0.0001). Conclusions: Bears have fewer innate immune cells in circulation during hibernation, which may represent a suppressed innate immune system. Across species comparison suggests that, both in small and large hibernators, Tb is the main driver of immune function regulation during winter dormancy. The lack of a difference in lymphocyte counts in this context requires further investigations. Article in Journal/Newspaper Arctic brown bear Ursus arctos Høgskolen i Innlandet: Brage INN Arctic International Journal of Medical Sciences 10 5 508 514 |
institution |
Open Polar |
collection |
Høgskolen i Innlandet: Brage INN |
op_collection_id |
fthsinnlandet |
language |
English |
topic |
brown bears ursus arctos hibernation innate immunity leukocytes torpor VDP::Mathematics and natural science: 400::Zoology and botany: 480 |
spellingShingle |
brown bears ursus arctos hibernation innate immunity leukocytes torpor VDP::Mathematics and natural science: 400::Zoology and botany: 480 Sahdo, Berolla Evans, Alina L. Arnemo, Jon Martin Fröbert, Ole Särndahl, Eva Blanc, Stéphane Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? |
topic_facet |
brown bears ursus arctos hibernation innate immunity leukocytes torpor VDP::Mathematics and natural science: 400::Zoology and botany: 480 |
description |
Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals (<5kg), in which Tb generally drop drastically, display leukopenia during hibernation. This raised the question of whether the decreased leukocyte counts in mammalian hibernators is due to torpor per se or is secondary to low Tb. The present study examined immune cell counts in brown bears (Ursus arctos), where torpor is only associated with shallow decreases in Tb. The results were compared across hibernator species for which immune and Tb data were available. Methods and Results: The white blood cell counts were determined by flow cytometry in 13 bears captured in the field both during summer and winter over 2 years time. Tb dropped from 39.6±0.8 to 33.5±1.1°C during hibernation. Blood neutrophils and monocytes were lower during hibernation than during the active period (47%, p= 0.001; 43%, p=0.039, respectively), whereas no change in lymphocyte counts was detected (p=0.599). Further, combining our data and those from 10 studies on 9 hibernating species suggested that the decline in Tb explained the decrease in innate immune cells (R2=0.83, p<0.0001). Conclusions: Bears have fewer innate immune cells in circulation during hibernation, which may represent a suppressed innate immune system. Across species comparison suggests that, both in small and large hibernators, Tb is the main driver of immune function regulation during winter dormancy. The lack of a difference in lymphocyte counts in this context requires further investigations. |
format |
Article in Journal/Newspaper |
author |
Sahdo, Berolla Evans, Alina L. Arnemo, Jon Martin Fröbert, Ole Särndahl, Eva Blanc, Stéphane |
author_facet |
Sahdo, Berolla Evans, Alina L. Arnemo, Jon Martin Fröbert, Ole Särndahl, Eva Blanc, Stéphane |
author_sort |
Sahdo, Berolla |
title |
Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? |
title_short |
Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? |
title_full |
Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? |
title_fullStr |
Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? |
title_full_unstemmed |
Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? |
title_sort |
body temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (ursus arctos): a common feature among hibernators? |
publisher |
IVYSPRING |
publishDate |
2013 |
url |
http://hdl.handle.net/11250/134538 https://doi.org/10.7150/ijms.4476 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic brown bear Ursus arctos |
genre_facet |
Arctic brown bear Ursus arctos |
op_source |
508-514 10 International Journal of Medical Sciences 5 |
op_relation |
http://www.medsci.org/v10p0508.htm Sahdo, B., Evans, A., Arnemo, J. M., Fröbert, O., Särndahl, E., & Blanc, S. (2013). Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? International Journal of Medical Sciences, 10(5), 508-514. doi: http://dx.doi.org/10.7150/ijms.4476 http://hdl.handle.net/11250/134538 https://doi.org/10.7150/ijms.4476 |
op_doi |
https://doi.org/10.7150/ijms.4476 |
container_title |
International Journal of Medical Sciences |
container_volume |
10 |
container_issue |
5 |
container_start_page |
508 |
op_container_end_page |
514 |
_version_ |
1792497709078282240 |