Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation
Dette er post-print versjonen av artikkelen. Den trykte versjonen kan leses her: http://www.sciencedirect.com/science/article/pii/S1873506111000286 In the den, hibernating brown bears do not develop tissue atrophy or organ damage, despite almost no physical activity. Mesenchymal stem cells could pla...
Published in: | Stem Cell Research |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Elsevier
2011
|
Subjects: | |
Online Access: | http://hdl.handle.net/11250/134346 https://doi.org/10.1016/j.scr.2011.03.003 |
id |
fthsinnlandet:oai:brage.inn.no:11250/134346 |
---|---|
record_format |
openpolar |
spelling |
fthsinnlandet:oai:brage.inn.no:11250/134346 2024-03-03T08:49:17+00:00 Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation Fink, Trine Rasmussen, Jeppe G. Emmersen, Jeppe Fahlman, Åsa Brunberg, Sven Josefsson, Johan Arnemo, Jon Martin Zachar, Vladimir Swenson, Jon E. Fröbert, Ole 2011 application/pdf http://hdl.handle.net/11250/134346 https://doi.org/10.1016/j.scr.2011.03.003 eng eng Elsevier Fink, T. Rasmussen, J.G., Emmersen, J., Fahlman, Å., Brunberg, S., Josefsson, J., Arnemo, J.M., Zachar, V., Swenson, J.E. & Fröbert, O. (2011). Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation. Stem Cell Research 7(1), 89-95 http://hdl.handle.net/11250/134346 http://dx.doi.org/10.1016/j.scr.2011.03.003 89-95 7 Stem Cell Research 1 brown bears ursus arctos hibernation Mesenchymal stem cells apidose osteogenesis chondrogenesis differentiation VDP::Mathematics and natural science: 400::Zoology and botany: 480::Zoological anatomy: 481 Journal article Peer reviewed 2011 fthsinnlandet https://doi.org/10.1016/j.scr.2011.03.003 2024-02-02T12:42:26Z Dette er post-print versjonen av artikkelen. Den trykte versjonen kan leses her: http://www.sciencedirect.com/science/article/pii/S1873506111000286 In the den, hibernating brown bears do not develop tissue atrophy or organ damage, despite almost no physical activity. Mesenchymal stem cells could play an important role in tissue repair and regeneration in brown bears. Our objective was to determine if adipose tissue-derived stem cells (ASCs) can be recovered from adipose tissue of wild Scandinavian brown bears and characterize osteogenic, chondrogenic, and adipogenic differentiation in the cells. Following immobilization of 8 wild brown bears 7-10 days after leaving the den in mid-April, adipose tissue biopsies (5-8 ml) were obtained subcutaneously from 7 bears. ASCs were recovered and characterized. Adipose stem cell cultures were established from 6 of 7 bears. Adipose tissue-derived stem cells from yearlings spontaneously formed bone-like nodules surrounded by cartilaginous deposits, suggesting differentiation into osteogenic and chondrogenic lineages. This ability appears to be lost gradually with age. This is the first study to demonstrate stem cell recovery and growth from brown bears, and it is the first report of ASCs spontaneously differentiating into osteocytes and chondrocytes. These findings could have implications for the use of hibernating brown bears as a model to study osteoporosis. Article in Journal/Newspaper Ursus arctos Høgskolen i Innlandet: Brage INN Stem Cell Research 7 1 89 95 |
institution |
Open Polar |
collection |
Høgskolen i Innlandet: Brage INN |
op_collection_id |
fthsinnlandet |
language |
English |
topic |
brown bears ursus arctos hibernation Mesenchymal stem cells apidose osteogenesis chondrogenesis differentiation VDP::Mathematics and natural science: 400::Zoology and botany: 480::Zoological anatomy: 481 |
spellingShingle |
brown bears ursus arctos hibernation Mesenchymal stem cells apidose osteogenesis chondrogenesis differentiation VDP::Mathematics and natural science: 400::Zoology and botany: 480::Zoological anatomy: 481 Fink, Trine Rasmussen, Jeppe G. Emmersen, Jeppe Fahlman, Åsa Brunberg, Sven Josefsson, Johan Arnemo, Jon Martin Zachar, Vladimir Swenson, Jon E. Fröbert, Ole Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation |
topic_facet |
brown bears ursus arctos hibernation Mesenchymal stem cells apidose osteogenesis chondrogenesis differentiation VDP::Mathematics and natural science: 400::Zoology and botany: 480::Zoological anatomy: 481 |
description |
Dette er post-print versjonen av artikkelen. Den trykte versjonen kan leses her: http://www.sciencedirect.com/science/article/pii/S1873506111000286 In the den, hibernating brown bears do not develop tissue atrophy or organ damage, despite almost no physical activity. Mesenchymal stem cells could play an important role in tissue repair and regeneration in brown bears. Our objective was to determine if adipose tissue-derived stem cells (ASCs) can be recovered from adipose tissue of wild Scandinavian brown bears and characterize osteogenic, chondrogenic, and adipogenic differentiation in the cells. Following immobilization of 8 wild brown bears 7-10 days after leaving the den in mid-April, adipose tissue biopsies (5-8 ml) were obtained subcutaneously from 7 bears. ASCs were recovered and characterized. Adipose stem cell cultures were established from 6 of 7 bears. Adipose tissue-derived stem cells from yearlings spontaneously formed bone-like nodules surrounded by cartilaginous deposits, suggesting differentiation into osteogenic and chondrogenic lineages. This ability appears to be lost gradually with age. This is the first study to demonstrate stem cell recovery and growth from brown bears, and it is the first report of ASCs spontaneously differentiating into osteocytes and chondrocytes. These findings could have implications for the use of hibernating brown bears as a model to study osteoporosis. |
format |
Article in Journal/Newspaper |
author |
Fink, Trine Rasmussen, Jeppe G. Emmersen, Jeppe Fahlman, Åsa Brunberg, Sven Josefsson, Johan Arnemo, Jon Martin Zachar, Vladimir Swenson, Jon E. Fröbert, Ole |
author_facet |
Fink, Trine Rasmussen, Jeppe G. Emmersen, Jeppe Fahlman, Åsa Brunberg, Sven Josefsson, Johan Arnemo, Jon Martin Zachar, Vladimir Swenson, Jon E. Fröbert, Ole |
author_sort |
Fink, Trine |
title |
Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation |
title_short |
Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation |
title_full |
Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation |
title_fullStr |
Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation |
title_full_unstemmed |
Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation |
title_sort |
adipose-derived stem cells from the brown bear (ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation |
publisher |
Elsevier |
publishDate |
2011 |
url |
http://hdl.handle.net/11250/134346 https://doi.org/10.1016/j.scr.2011.03.003 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
89-95 7 Stem Cell Research 1 |
op_relation |
Fink, T. Rasmussen, J.G., Emmersen, J., Fahlman, Å., Brunberg, S., Josefsson, J., Arnemo, J.M., Zachar, V., Swenson, J.E. & Fröbert, O. (2011). Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation. Stem Cell Research 7(1), 89-95 http://hdl.handle.net/11250/134346 http://dx.doi.org/10.1016/j.scr.2011.03.003 |
op_doi |
https://doi.org/10.1016/j.scr.2011.03.003 |
container_title |
Stem Cell Research |
container_volume |
7 |
container_issue |
1 |
container_start_page |
89 |
op_container_end_page |
95 |
_version_ |
1792506482642649088 |