Mixed Anhydrides of Penicillinic and Cephalosporinic Acids with N-Acyl Carbamic Acid

Mixed anhydrides with penicillinic acids (III) were unstable and gave N-acyl, amides IV. Only III with butyrolactam was stable and reacted with alcohols to give esters V. All anhydrides with cephalosporinic acids (VIlI) yielded symmetric anhydrides IX. Alcoholysis of IX gave cephalosporinic ester X,...

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Bibliographic Details
Main Authors: Kovačević, Miće, Herak, Jure J., Gašpert, Branimir
Format: Article in Journal/Newspaper
Language:English
Published: Croatian Chemical Society 1985
Subjects:
Carbonic acid
Online Access:http://hrcak.srce.hr/177771
http://hrcak.srce.hr/file/262003
Description
Summary:Mixed anhydrides with penicillinic acids (III) were unstable and gave N-acyl, amides IV. Only III with butyrolactam was stable and reacted with alcohols to give esters V. All anhydrides with cephalosporinic acids (VIlI) yielded symmetric anhydrides IX. Alcoholysis of IX gave cephalosporinic ester X, while aminolysis yielded amide. Formation of postulated isomeric mixed anhydride with O-imino carbonic acid ester XlIIb is discussed.

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