Prognostic Value of IL-5 in Sinus Lavage in Patients with Chronic Maxillary Sinusitis
The aim of the study was to evaluate subjective outcomes in patients with chronic rhinosinusitis after steroid/antibiotic endosinusal treatment and to test the hypothesis that pretreatment levels of the cytokine interleukin-5 in sinus fluid could predict response to endosinusal steroid/antibiotic tr...
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Sestre Milosrdnice University hospital and Institute of Clinical Medical Research; acta@kbcsm.hr
2003
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Online Access: | http://hrcak.srce.hr/14694 http://hrcak.srce.hr/file/22453 |
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fthrcak:oai:hrcak.srce.hr:14694 |
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Hrčak - Portal of scientific journals of Croatia |
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fthrcak |
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English |
topic |
Maxillary sinusitis - drug therapy Chronic disease Sinusitis - complications Cytokines - metabolism Maksilarni sinusitis - medikamentno liječenje Kronična bolest Sinusitis - komplikacije Citokini - metabolizam |
spellingShingle |
Maxillary sinusitis - drug therapy Chronic disease Sinusitis - complications Cytokines - metabolism Maksilarni sinusitis - medikamentno liječenje Kronična bolest Sinusitis - komplikacije Citokini - metabolizam Drviš, Petar Kalogjera, Livije Baudoin, Tomislav Prognostic Value of IL-5 in Sinus Lavage in Patients with Chronic Maxillary Sinusitis |
topic_facet |
Maxillary sinusitis - drug therapy Chronic disease Sinusitis - complications Cytokines - metabolism Maksilarni sinusitis - medikamentno liječenje Kronična bolest Sinusitis - komplikacije Citokini - metabolizam |
description |
The aim of the study was to evaluate subjective outcomes in patients with chronic rhinosinusitis after steroid/antibiotic endosinusal treatment and to test the hypothesis that pretreatment levels of the cytokine interleukin-5 in sinus fluid could predict response to endosinusal steroid/antibiotic treatment. Twenty-four patients with symptoms of chronic rhinosinusitis were recruited for the study. Inclusion criteria were sinusitis symptoms persisting for more than three months and maxillary sinus mucosa thickening by >6 mm, considered as maxillary sinusitis. Patients with asthma, polyposis, recent infection, systemic steroid therapy or previous sinus surgery were excluded. Patients were treated endosinusally with 2 mg dexamethasone and 40 mg gentamicin per maxillary sinus daily for 5 days. Patients rated nasal/chronic rhinosinusitis disease-specific symptoms and completed a self-administered questionnaire concerning sinusitis symptoms at inclusion and after 30 days. Sinus lavage collected at inclusion was analyzed for interleukin-5 concentration. Endonasal treatment led to improvement with symptom alleviation in ten (52.6%) patients (responders), whereas unchanged or worsened condition was recorded in nine (47.4%) patients (nonresponders). Significant improvement was noted for overall sinusitis symptom score (p=0.02), and for obstruction, postnasal drip, headache, sneezing and cough (p<0.05) in the study group as a whole. There was a positive correlation of baseline interleukin-5 level in sinus lavage with the improvement rate of overall sinusitis symptom score (p<0.01) and improvement rate of nasal secretion score (p<0.01). Results indicated the increased interleukin-5 levels in sinus fluid to predict good response to endosinusal steroid/antibiotic treatment. Cilj studije bio je procijeniti subjektivne ishode u bolesnika s kroničnim rinosinusitisom nakon endosinusne steroidne/ antibiotske terapije, te ispitati pretpostavku prema kojoj bi se iz prijeterapijske razine citokina interleukina-5 u sinusnoj tekućini mogao predvidjeti odgovor na ovu vrst liječenja. U studiju je bilo uključeno 24 bolesnika sa simptomima kroničnog rinosinusitisa. Kriteriji za uključivanje u studiju bili su trajanje simptoma sinusitisa duže od tri mjeseca i zadebljanje sluznice maksilarnih sinusa za više od 6 mm, tj. maksilarni sinusitis. Bolesnici s astmom, polipozom, nedavnom infekcijom, sistemskom uporabom steroida ili prethodnom operacijom sinusa bili su isključeni. Bolesnici su endosinusno primali 2 mg deksametazona i 40 mg gentamicina po maksilarnom sinusu kroz 5 dana. Bolesnici su ocjenjivali nosne simptome i simptome specifične za kronični rinosinusitis, i sami ispunili anketni obrazac o simptomima sinusitisa na početku i 30 dana nakon ispitivanja. Koncentracija interleukina-5 analizirana je u sinusnom ispirku uzetom na početku studije. U desetoro (52,6%) bolesnika je nakon endonazalne terapije nastupilo poboljšanje s ublaženjem simptoma (bolesnici s terapijskim odgovorom), dok je u devetoro (47,4%) bolesnika stanje ostalo nepromijenjeno ili se je pogoršalo (bolesnici bez terapijskog odgovora). Značajno je poboljšanje zabilježeno za ukupni zbroj simptoma sinusitisa (p=0,02), te za opstrukciju, postnazalni drip, glavobolju, kihanje i kašalj (p<0,05) u cijeloj skupini. Nađena je pozitivna korelacija između bazalne razine interleukina-5 u sinusnom ispirku i stope poboljšanja sveukupnog zbroja simptoma sinusitisa (p<0,01), kao i stope poboljšanja zbroja za nazalnu sekreciju (p<0,01). Rezultati su pokazali kako povišene razine interleukina-5 u sinusnoj tekućini predskazuju dobar odgovor na endosinusnu steroidnu/antibiotsku terapiju. |
format |
Text |
author |
Drviš, Petar Kalogjera, Livije Baudoin, Tomislav |
author_facet |
Drviš, Petar Kalogjera, Livije Baudoin, Tomislav |
author_sort |
Drviš, Petar |
title |
Prognostic Value of IL-5 in Sinus Lavage in Patients with Chronic Maxillary Sinusitis |
title_short |
Prognostic Value of IL-5 in Sinus Lavage in Patients with Chronic Maxillary Sinusitis |
title_full |
Prognostic Value of IL-5 in Sinus Lavage in Patients with Chronic Maxillary Sinusitis |
title_fullStr |
Prognostic Value of IL-5 in Sinus Lavage in Patients with Chronic Maxillary Sinusitis |
title_full_unstemmed |
Prognostic Value of IL-5 in Sinus Lavage in Patients with Chronic Maxillary Sinusitis |
title_sort |
prognostic value of il-5 in sinus lavage in patients with chronic maxillary sinusitis |
publisher |
Sestre Milosrdnice University hospital and Institute of Clinical Medical Research; acta@kbcsm.hr |
publishDate |
2003 |
url |
http://hrcak.srce.hr/14694 http://hrcak.srce.hr/file/22453 |
genre |
sami |
genre_facet |
sami |
op_source |
Acta Clinica Croatica (acta@kbcsm.hr); Vol.42 No.4 |
op_relation |
http://hrcak.srce.hr/14694 http://hrcak.srce.hr/file/22453 |
_version_ |
1766186881043660800 |
spelling |
fthrcak:oai:hrcak.srce.hr:14694 2023-05-15T18:14:10+02:00 Prognostic Value of IL-5 in Sinus Lavage in Patients with Chronic Maxillary Sinusitis Prognostička vrijednost IL-5 u sinusnom ispirku kod bolesnika s kroničnim maksilarnim sinusitisom Drviš, Petar Kalogjera, Livije Baudoin, Tomislav 2003-12-01 pdf http://hrcak.srce.hr/14694 http://hrcak.srce.hr/file/22453 en eng Sestre Milosrdnice University hospital and Institute of Clinical Medical Research; acta@kbcsm.hr http://hrcak.srce.hr/14694 http://hrcak.srce.hr/file/22453 Acta Clinica Croatica (acta@kbcsm.hr); Vol.42 No.4 Maxillary sinusitis - drug therapy Chronic disease Sinusitis - complications Cytokines - metabolism Maksilarni sinusitis - medikamentno liječenje Kronična bolest Sinusitis - komplikacije Citokini - metabolizam text 2003 fthrcak 2012-10-27T10:04:50Z The aim of the study was to evaluate subjective outcomes in patients with chronic rhinosinusitis after steroid/antibiotic endosinusal treatment and to test the hypothesis that pretreatment levels of the cytokine interleukin-5 in sinus fluid could predict response to endosinusal steroid/antibiotic treatment. Twenty-four patients with symptoms of chronic rhinosinusitis were recruited for the study. Inclusion criteria were sinusitis symptoms persisting for more than three months and maxillary sinus mucosa thickening by >6 mm, considered as maxillary sinusitis. Patients with asthma, polyposis, recent infection, systemic steroid therapy or previous sinus surgery were excluded. Patients were treated endosinusally with 2 mg dexamethasone and 40 mg gentamicin per maxillary sinus daily for 5 days. Patients rated nasal/chronic rhinosinusitis disease-specific symptoms and completed a self-administered questionnaire concerning sinusitis symptoms at inclusion and after 30 days. Sinus lavage collected at inclusion was analyzed for interleukin-5 concentration. Endonasal treatment led to improvement with symptom alleviation in ten (52.6%) patients (responders), whereas unchanged or worsened condition was recorded in nine (47.4%) patients (nonresponders). Significant improvement was noted for overall sinusitis symptom score (p=0.02), and for obstruction, postnasal drip, headache, sneezing and cough (p<0.05) in the study group as a whole. There was a positive correlation of baseline interleukin-5 level in sinus lavage with the improvement rate of overall sinusitis symptom score (p<0.01) and improvement rate of nasal secretion score (p<0.01). Results indicated the increased interleukin-5 levels in sinus fluid to predict good response to endosinusal steroid/antibiotic treatment. Cilj studije bio je procijeniti subjektivne ishode u bolesnika s kroničnim rinosinusitisom nakon endosinusne steroidne/ antibiotske terapije, te ispitati pretpostavku prema kojoj bi se iz prijeterapijske razine citokina interleukina-5 u sinusnoj tekućini mogao predvidjeti odgovor na ovu vrst liječenja. U studiju je bilo uključeno 24 bolesnika sa simptomima kroničnog rinosinusitisa. Kriteriji za uključivanje u studiju bili su trajanje simptoma sinusitisa duže od tri mjeseca i zadebljanje sluznice maksilarnih sinusa za više od 6 mm, tj. maksilarni sinusitis. Bolesnici s astmom, polipozom, nedavnom infekcijom, sistemskom uporabom steroida ili prethodnom operacijom sinusa bili su isključeni. Bolesnici su endosinusno primali 2 mg deksametazona i 40 mg gentamicina po maksilarnom sinusu kroz 5 dana. Bolesnici su ocjenjivali nosne simptome i simptome specifične za kronični rinosinusitis, i sami ispunili anketni obrazac o simptomima sinusitisa na početku i 30 dana nakon ispitivanja. Koncentracija interleukina-5 analizirana je u sinusnom ispirku uzetom na početku studije. U desetoro (52,6%) bolesnika je nakon endonazalne terapije nastupilo poboljšanje s ublaženjem simptoma (bolesnici s terapijskim odgovorom), dok je u devetoro (47,4%) bolesnika stanje ostalo nepromijenjeno ili se je pogoršalo (bolesnici bez terapijskog odgovora). Značajno je poboljšanje zabilježeno za ukupni zbroj simptoma sinusitisa (p=0,02), te za opstrukciju, postnazalni drip, glavobolju, kihanje i kašalj (p<0,05) u cijeloj skupini. Nađena je pozitivna korelacija između bazalne razine interleukina-5 u sinusnom ispirku i stope poboljšanja sveukupnog zbroja simptoma sinusitisa (p<0,01), kao i stope poboljšanja zbroja za nazalnu sekreciju (p<0,01). Rezultati su pokazali kako povišene razine interleukina-5 u sinusnoj tekućini predskazuju dobar odgovor na endosinusnu steroidnu/antibiotsku terapiju. Text sami Hrčak - Portal of scientific journals of Croatia |