Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice
The health benefits of eicosapentaenoic acid (EPA)-enriched phospholipids (PL) have witnessed a recent upsurge. In the present study, PL from starfish Asterias amurensis (SFP) and sea cucumber Cucumaria frondosa (SCP) were extracted and the liposomes were prepared. Both SFP and SCP liposomes showed...
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fthokunivhus:oai:eprints.lib.hokudai.ac.jp:2115/63704 2023-05-15T15:59:38+02:00 Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice Du, Lei Yang, Yu-Hong Wang, Yu-Ming Xue, Chang-Hu Kurihara, Hideyuki Takahashi, Koretaro http://hdl.handle.net/2115/63704 https://doi.org/10.1016/j.jff.2015.06.061 eng eng Elsevier http://hdl.handle.net/2115/63704 Journal of functional foods, 19: 970-982 http://dx.doi.org/10.1016/j.jff.2015.06.061 © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CC-BY-NC-ND EPA-enriched phospholipids Liposomes S180 ascitic tumour Antioxidant Mitochondrial apoptotic pathways 660 article (author version) fthokunivhus https://doi.org/10.1016/j.jff.2015.06.061 2022-11-18T01:03:41Z The health benefits of eicosapentaenoic acid (EPA)-enriched phospholipids (PL) have witnessed a recent upsurge. In the present study, PL from starfish Asterias amurensis (SFP) and sea cucumber Cucumaria frondosa (SCP) were extracted and the liposomes were prepared. Both SFP and SCP liposomes showed antitumour effects in vitro and exhibited high transport and uptake effects in small intestinal epithelial cell models. The results also demonstrated that dietary SFP and SCP liposomes prolonged the life span and ameliorated oxidative stress status of S180 ascitic tumour-bearing mice. Results also showed that dietary SFP and SCP liposomes up-regulated the expression of Bax and down-regulated Bcl-2 level in tumour cells, then induced release of cytochrome c from mitochondria to cytosol, thus the activation of caspase 9 and caspase 3. Taken together, these findings suggest that SFP and SCP liposomes exert antitumour effects mainly via activation of mitochondrial apoptotic pathways in tumour-bearing mice. (C) 2015 Elsevier Ltd. All rights reserved. Article in Journal/Newspaper Cucumaria frondosa Hokkaido University Collection of Scholarly and Academic Papers (HUSCAP) Journal of Functional Foods 19 970 982 |
institution |
Open Polar |
collection |
Hokkaido University Collection of Scholarly and Academic Papers (HUSCAP) |
op_collection_id |
fthokunivhus |
language |
English |
topic |
EPA-enriched phospholipids Liposomes S180 ascitic tumour Antioxidant Mitochondrial apoptotic pathways 660 |
spellingShingle |
EPA-enriched phospholipids Liposomes S180 ascitic tumour Antioxidant Mitochondrial apoptotic pathways 660 Du, Lei Yang, Yu-Hong Wang, Yu-Ming Xue, Chang-Hu Kurihara, Hideyuki Takahashi, Koretaro Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice |
topic_facet |
EPA-enriched phospholipids Liposomes S180 ascitic tumour Antioxidant Mitochondrial apoptotic pathways 660 |
description |
The health benefits of eicosapentaenoic acid (EPA)-enriched phospholipids (PL) have witnessed a recent upsurge. In the present study, PL from starfish Asterias amurensis (SFP) and sea cucumber Cucumaria frondosa (SCP) were extracted and the liposomes were prepared. Both SFP and SCP liposomes showed antitumour effects in vitro and exhibited high transport and uptake effects in small intestinal epithelial cell models. The results also demonstrated that dietary SFP and SCP liposomes prolonged the life span and ameliorated oxidative stress status of S180 ascitic tumour-bearing mice. Results also showed that dietary SFP and SCP liposomes up-regulated the expression of Bax and down-regulated Bcl-2 level in tumour cells, then induced release of cytochrome c from mitochondria to cytosol, thus the activation of caspase 9 and caspase 3. Taken together, these findings suggest that SFP and SCP liposomes exert antitumour effects mainly via activation of mitochondrial apoptotic pathways in tumour-bearing mice. (C) 2015 Elsevier Ltd. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Du, Lei Yang, Yu-Hong Wang, Yu-Ming Xue, Chang-Hu Kurihara, Hideyuki Takahashi, Koretaro |
author_facet |
Du, Lei Yang, Yu-Hong Wang, Yu-Ming Xue, Chang-Hu Kurihara, Hideyuki Takahashi, Koretaro |
author_sort |
Du, Lei |
title |
Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice |
title_short |
Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice |
title_full |
Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice |
title_fullStr |
Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice |
title_full_unstemmed |
Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice |
title_sort |
antitumour activity of epa-enriched phospholipids liposomes against s180 ascitic tumour-bearing mice |
publisher |
Elsevier |
url |
http://hdl.handle.net/2115/63704 https://doi.org/10.1016/j.jff.2015.06.061 |
genre |
Cucumaria frondosa |
genre_facet |
Cucumaria frondosa |
op_relation |
http://hdl.handle.net/2115/63704 Journal of functional foods, 19: 970-982 http://dx.doi.org/10.1016/j.jff.2015.06.061 |
op_rights |
© 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.jff.2015.06.061 |
container_title |
Journal of Functional Foods |
container_volume |
19 |
container_start_page |
970 |
op_container_end_page |
982 |
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1766395567637790720 |