Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus
The aim of study was to investigate the toxic effect of triptolide fed in bait on reproduction of male house rat, Rattus rattus. Feeding of cereal based bait containing 0.2% triptolide to male R. rattus for 5 days in no-choice feeding test, leading to mean daily ingestion of 20.45 mg/kg bw of tripto...
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fthindawi:oai:hindawi.com:10.1155/2014/879405 2023-05-15T18:04:47+02:00 Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus Neena Singla Swati Challana 2014 https://doi.org/10.1155/2014/879405 en eng The Scientific World Journal https://doi.org/10.1155/2014/879405 Copyright © 2014 Neena Singla and Swati Challana. Toxicology Research Article 2014 fthindawi https://doi.org/10.1155/2014/879405 2019-05-26T01:14:55Z The aim of study was to investigate the toxic effect of triptolide fed in bait on reproduction of male house rat, Rattus rattus. Feeding of cereal based bait containing 0.2% triptolide to male R. rattus for 5 days in no-choice feeding test, leading to mean daily ingestion of 20.45 mg/kg bw of triptolide, was found effective in significantly (P≤0.05) reducing sperm motility and viability in cauda epididymal fluid by 80.65 and 75.14%, respectively, from that of untreated rats. Pregnancy rates were decreased by 100% in untreated cyclic female rats paired with male rats treated with 0.2% triptolide. Present studies suggest the potential of 0.2% triptolide bait in regulating reproductive output of R. rattus. Article in Journal/Newspaper Rattus rattus Hindawi Publishing Corporation The Scientific World Journal 2014 1 6 |
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Hindawi Publishing Corporation |
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English |
topic |
Toxicology |
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Toxicology Neena Singla Swati Challana Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
topic_facet |
Toxicology |
description |
The aim of study was to investigate the toxic effect of triptolide fed in bait on reproduction of male house rat, Rattus rattus. Feeding of cereal based bait containing 0.2% triptolide to male R. rattus for 5 days in no-choice feeding test, leading to mean daily ingestion of 20.45 mg/kg bw of triptolide, was found effective in significantly (P≤0.05) reducing sperm motility and viability in cauda epididymal fluid by 80.65 and 75.14%, respectively, from that of untreated rats. Pregnancy rates were decreased by 100% in untreated cyclic female rats paired with male rats treated with 0.2% triptolide. Present studies suggest the potential of 0.2% triptolide bait in regulating reproductive output of R. rattus. |
format |
Article in Journal/Newspaper |
author |
Neena Singla Swati Challana |
author_facet |
Neena Singla Swati Challana |
author_sort |
Neena Singla |
title |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_short |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_full |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_fullStr |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_full_unstemmed |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_sort |
reproductive toxicity of triptolide in male house rat, rattus rattus |
publisher |
The Scientific World Journal |
publishDate |
2014 |
url |
https://doi.org/10.1155/2014/879405 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
https://doi.org/10.1155/2014/879405 |
op_rights |
Copyright © 2014 Neena Singla and Swati Challana. |
op_doi |
https://doi.org/10.1155/2014/879405 |
container_title |
The Scientific World Journal |
container_volume |
2014 |
container_start_page |
1 |
op_container_end_page |
6 |
_version_ |
1766176204433391616 |