Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid
Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid gen...
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fthindawi:oai:hindawi.com:10.1155/2014/756418 2023-05-15T14:01:25+02:00 Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh 2014 https://doi.org/10.1155/2014/756418 en eng The Scientific World Journal https://doi.org/10.1155/2014/756418 Copyright © 2014 Emilia Abdulmalek et al. Biotechnology Research Article 2014 fthindawi https://doi.org/10.1155/2014/756418 2019-05-25T23:01:45Z Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid generated was then utilised directly for in situ oxidation of alkenes. A variety of alkenes were oxidised with this system, resulting in 75–99% yield of the respective epoxides. On the other hand, the phenylacetic acid was recovered from the reaction media and reused for more epoxidation. Interestingly, the waste phenylacetic acid had the ability to be reused for epoxidation of the 1-nonene to 1-nonene oxide, giving an excellent yield of 90%. Article in Journal/Newspaper Antarc* Antarctica Hindawi Publishing Corporation The Scientific World Journal 2014 1 7 |
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Hindawi Publishing Corporation |
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English |
topic |
Biotechnology |
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Biotechnology Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
topic_facet |
Biotechnology |
description |
Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid generated was then utilised directly for in situ oxidation of alkenes. A variety of alkenes were oxidised with this system, resulting in 75–99% yield of the respective epoxides. On the other hand, the phenylacetic acid was recovered from the reaction media and reused for more epoxidation. Interestingly, the waste phenylacetic acid had the ability to be reused for epoxidation of the 1-nonene to 1-nonene oxide, giving an excellent yield of 90%. |
format |
Article in Journal/Newspaper |
author |
Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh |
author_facet |
Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh |
author_sort |
Emilia Abdulmalek |
title |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_short |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_full |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_fullStr |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_full_unstemmed |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_sort |
chemoenzymatic epoxidation of alkenes and reusability study of the phenylacetic acid |
publisher |
The Scientific World Journal |
publishDate |
2014 |
url |
https://doi.org/10.1155/2014/756418 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
https://doi.org/10.1155/2014/756418 |
op_rights |
Copyright © 2014 Emilia Abdulmalek et al. |
op_doi |
https://doi.org/10.1155/2014/756418 |
container_title |
The Scientific World Journal |
container_volume |
2014 |
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1 |
op_container_end_page |
7 |
_version_ |
1766271229456547840 |