Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)

The most common cardiac tumors of heart muscle are rhabdomyomas, solitary or multiple benign tumors of striated muscle origin. While cardiac rhabdomyomas are well described in human medical literature, limited information depicting the occurrence of cardiac rhabdomyomas in veterinary species exists....

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Published in:Case Reports in Veterinary Medicine
Main Authors: G. Krafsur, E. J. Ehrhart, J. Ramos-Vara, G. Mason, F. Sarren, B. Adams, C. Hanns, T. Spraker, C. Duncan
Format: Report
Language:English
Published: Case Reports in Veterinary Medicine 2014
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Online Access:https://doi.org/10.1155/2014/103279
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spelling fthindawi:oai:hindawi.com:10.1155/2014/103279 2023-05-15T15:40:03+02:00 Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus) G. Krafsur E. J. Ehrhart J. Ramos-Vara G. Mason F. Sarren B. Adams C. Hanns T. Spraker C. Duncan 2014 https://doi.org/10.1155/2014/103279 en eng Case Reports in Veterinary Medicine https://doi.org/10.1155/2014/103279 Copyright © 2014 G. Krafsur et al. Case Report 2014 fthindawi https://doi.org/10.1155/2014/103279 2019-05-26T03:27:13Z The most common cardiac tumors of heart muscle are rhabdomyomas, solitary or multiple benign tumors of striated muscle origin. While cardiac rhabdomyomas are well described in human medical literature, limited information depicting the occurrence of cardiac rhabdomyomas in veterinary species exists. A case of multiple firm white nonencapsulated nodules in the heart of a bearded seal is described. Microscopic findings included cytoplasmic vacuolization with formation of spider cells, glycogen vacuoles, and striated myofibrils. These cells expressed immunoreactivity for neuron-specific enolase and protein gene product 9.5, a marker for neuronal tissue and Purkinje fiber cells. Immunoreactivity for protein gene product 9.5 along with other microscopic findings substantiates Purkinje fiber cell origin of the cardiac rhabdomyoma in the bearded seal and use of the term purkinjeoma to describe this lesion. Report bearded seal Erignathus barbatus Hindawi Publishing Corporation Case Reports in Veterinary Medicine 2014 1 4
institution Open Polar
collection Hindawi Publishing Corporation
op_collection_id fthindawi
language English
description The most common cardiac tumors of heart muscle are rhabdomyomas, solitary or multiple benign tumors of striated muscle origin. While cardiac rhabdomyomas are well described in human medical literature, limited information depicting the occurrence of cardiac rhabdomyomas in veterinary species exists. A case of multiple firm white nonencapsulated nodules in the heart of a bearded seal is described. Microscopic findings included cytoplasmic vacuolization with formation of spider cells, glycogen vacuoles, and striated myofibrils. These cells expressed immunoreactivity for neuron-specific enolase and protein gene product 9.5, a marker for neuronal tissue and Purkinje fiber cells. Immunoreactivity for protein gene product 9.5 along with other microscopic findings substantiates Purkinje fiber cell origin of the cardiac rhabdomyoma in the bearded seal and use of the term purkinjeoma to describe this lesion.
format Report
author G. Krafsur
E. J. Ehrhart
J. Ramos-Vara
G. Mason
F. Sarren
B. Adams
C. Hanns
T. Spraker
C. Duncan
spellingShingle G. Krafsur
E. J. Ehrhart
J. Ramos-Vara
G. Mason
F. Sarren
B. Adams
C. Hanns
T. Spraker
C. Duncan
Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)
author_facet G. Krafsur
E. J. Ehrhart
J. Ramos-Vara
G. Mason
F. Sarren
B. Adams
C. Hanns
T. Spraker
C. Duncan
author_sort G. Krafsur
title Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)
title_short Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)
title_full Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)
title_fullStr Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)
title_full_unstemmed Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)
title_sort histomorphologic and immunohistochemical characterization of a cardiac purkinjeoma in a bearded seal (erignathus barbatus)
publisher Case Reports in Veterinary Medicine
publishDate 2014
url https://doi.org/10.1155/2014/103279
genre bearded seal
Erignathus barbatus
genre_facet bearded seal
Erignathus barbatus
op_relation https://doi.org/10.1155/2014/103279
op_rights Copyright © 2014 G. Krafsur et al.
op_doi https://doi.org/10.1155/2014/103279
container_title Case Reports in Veterinary Medicine
container_volume 2014
container_start_page 1
op_container_end_page 4
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