Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress
This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes. An ethyl acetate extract of E. nigrum (ENE) increased cell viability decreased by exposure to UVB rays. ENE also absorbed UVB radiation and scavenged UVB-induced intrac...
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fthindawi:oai:hindawi.com:10.1155/2013/983609 2023-05-15T16:06:03+02:00 Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress Ki Cheon Kim Daeshin Kim Sang Cheol Kim Eunsun Jung Deokhoon Park Jin Won Hyun 2013 https://doi.org/10.1155/2013/983609 en eng Evidence-Based Complementary and Alternative Medicine https://doi.org/10.1155/2013/983609 Copyright © 2013 Ki Cheon Kim et al. Research Article 2013 fthindawi https://doi.org/10.1155/2013/983609 2019-05-26T04:06:55Z This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes. An ethyl acetate extract of E. nigrum (ENE) increased cell viability decreased by exposure to UVB rays. ENE also absorbed UVB radiation and scavenged UVB-induced intracellular reactive oxygen species (ROS) in HaCaT keratinocytes. In addition, ENE shielded HaCaT keratinocytes from damage to cellular components (e.g., peroxidation of lipids, modification of proteins, and breakage of DNA strands) following UVB irradiation. Furthermore, ENE protected against UVB-induced apoptotic cell death, as determined by a reduction in the numbers of apoptotic bodies and sub-G1 hypodiploid cells, as well as by the recovery of mitochondrial membrane potential. The results of the current study therefore suggest that ENE safeguards human keratinocytes against UVB-induced cellular damage via the absorption of UVB ray and scavenging of UVB-generated ROS. Article in Journal/Newspaper Empetrum nigrum Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine 2013 1 10 |
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This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes. An ethyl acetate extract of E. nigrum (ENE) increased cell viability decreased by exposure to UVB rays. ENE also absorbed UVB radiation and scavenged UVB-induced intracellular reactive oxygen species (ROS) in HaCaT keratinocytes. In addition, ENE shielded HaCaT keratinocytes from damage to cellular components (e.g., peroxidation of lipids, modification of proteins, and breakage of DNA strands) following UVB irradiation. Furthermore, ENE protected against UVB-induced apoptotic cell death, as determined by a reduction in the numbers of apoptotic bodies and sub-G1 hypodiploid cells, as well as by the recovery of mitochondrial membrane potential. The results of the current study therefore suggest that ENE safeguards human keratinocytes against UVB-induced cellular damage via the absorption of UVB ray and scavenging of UVB-generated ROS. |
format |
Article in Journal/Newspaper |
author |
Ki Cheon Kim Daeshin Kim Sang Cheol Kim Eunsun Jung Deokhoon Park Jin Won Hyun |
spellingShingle |
Ki Cheon Kim Daeshin Kim Sang Cheol Kim Eunsun Jung Deokhoon Park Jin Won Hyun Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
author_facet |
Ki Cheon Kim Daeshin Kim Sang Cheol Kim Eunsun Jung Deokhoon Park Jin Won Hyun |
author_sort |
Ki Cheon Kim |
title |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_short |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_full |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_fullStr |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_full_unstemmed |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_sort |
empetrum nigrum var. japonicum extract suppresses ultraviolet b-induced cell damage via absorption of radiation and inhibition of oxidative stress |
publisher |
Evidence-Based Complementary and Alternative Medicine |
publishDate |
2013 |
url |
https://doi.org/10.1155/2013/983609 |
genre |
Empetrum nigrum |
genre_facet |
Empetrum nigrum |
op_relation |
https://doi.org/10.1155/2013/983609 |
op_rights |
Copyright © 2013 Ki Cheon Kim et al. |
op_doi |
https://doi.org/10.1155/2013/983609 |
container_title |
Evidence-Based Complementary and Alternative Medicine |
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2013 |
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1 |
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10 |
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1766401969153376256 |