Potential Use of Atlantic Cod Trypsin in Biomedicine
Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be...
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fthindawi:oai:hindawi.com:10.1155/2013/749078 2023-05-15T15:27:11+02:00 Potential Use of Atlantic Cod Trypsin in Biomedicine Ágústa Gudmundsdóttir Hilmar Hilmarsson Bjarki Stefansson 2013 https://doi.org/10.1155/2013/749078 en eng BioMed Research International https://doi.org/10.1155/2013/749078 Copyright © 2013 Ágústa Gudmundsdóttir et al. Biochemistry Review Article 2013 fthindawi https://doi.org/10.1155/2013/749078 2019-05-25T23:34:25Z Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be 3–12 times more effective in degrading large native proteins than its mesophilic analogue, bovine trypsin. This is in agreement with previous findings where cod trypsin was found to be the most active among twelve different proteases in cleaving various cytokines and pathological proteins. Furthermore, our results show that cod trypsin has high efficacy against herpes simplex virus type 1 (HSV-1) and the respiratory syncytial virus (RSV) in vitro. The results on the antipathogenic properties of cod trypsin are important because rhinovirus, RSV, and influenza are the most predominant pathogenic viruses in upper respiratory tract infections. Results from a clinical study presented in this paper show that a specific formulation containing cod trypsin was preferred for wound healing over other methods used in the study. Apparently, the high digestive ability of the cold-adapted cod trypsin towards large native proteins plays a role in its efficacy against pathogens and its positive effects on wounds. Review atlantic cod Gadus morhua Hindawi Publishing Corporation BioMed Research International 2013 1 11 |
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Biochemistry |
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Biochemistry Ágústa Gudmundsdóttir Hilmar Hilmarsson Bjarki Stefansson Potential Use of Atlantic Cod Trypsin in Biomedicine |
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Biochemistry |
description |
Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be 3–12 times more effective in degrading large native proteins than its mesophilic analogue, bovine trypsin. This is in agreement with previous findings where cod trypsin was found to be the most active among twelve different proteases in cleaving various cytokines and pathological proteins. Furthermore, our results show that cod trypsin has high efficacy against herpes simplex virus type 1 (HSV-1) and the respiratory syncytial virus (RSV) in vitro. The results on the antipathogenic properties of cod trypsin are important because rhinovirus, RSV, and influenza are the most predominant pathogenic viruses in upper respiratory tract infections. Results from a clinical study presented in this paper show that a specific formulation containing cod trypsin was preferred for wound healing over other methods used in the study. Apparently, the high digestive ability of the cold-adapted cod trypsin towards large native proteins plays a role in its efficacy against pathogens and its positive effects on wounds. |
format |
Review |
author |
Ágústa Gudmundsdóttir Hilmar Hilmarsson Bjarki Stefansson |
author_facet |
Ágústa Gudmundsdóttir Hilmar Hilmarsson Bjarki Stefansson |
author_sort |
Ágústa Gudmundsdóttir |
title |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_short |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_full |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_fullStr |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_full_unstemmed |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_sort |
potential use of atlantic cod trypsin in biomedicine |
publisher |
BioMed Research International |
publishDate |
2013 |
url |
https://doi.org/10.1155/2013/749078 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_relation |
https://doi.org/10.1155/2013/749078 |
op_rights |
Copyright © 2013 Ágústa Gudmundsdóttir et al. |
op_doi |
https://doi.org/10.1155/2013/749078 |
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BioMed Research International |
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2013 |
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1 |
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11 |
_version_ |
1766357642148577280 |