History of Cesarean Section Associated with Childhood Onset of T1DM in Newfoundland and Labrador, Canada
Objectives. Newfoundland and Labrador (NL) has one of the highest incidences of Type 1 diabetes mellitus (T1DM) worldwide. Rates of T1DM are increasing and the search for environmental factors that may be contributing to this increase is continuing. Methods. This was a population-based case control...
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fthindawi:oai:hindawi.com:10.1155/2012/635097 2023-05-15T17:21:39+02:00 History of Cesarean Section Associated with Childhood Onset of T1DM in Newfoundland and Labrador, Canada J. Phillips N. Gill K. Sikdar S. Penney L. A. Newhook 2012 https://doi.org/10.1155/2012/635097 en eng Journal of Environmental and Public Health https://doi.org/10.1155/2012/635097 Copyright © 2012 J. Phillips et al. Research Article 2012 fthindawi https://doi.org/10.1155/2012/635097 2019-05-26T04:41:35Z Objectives. Newfoundland and Labrador (NL) has one of the highest incidences of Type 1 diabetes mellitus (T1DM) worldwide. Rates of T1DM are increasing and the search for environmental factors that may be contributing to this increase is continuing. Methods. This was a population-based case control design involving the linkage of data from a diabetes database with live birth registration data. 266 children aged 0–15 years with T1DM were compared to age- and gender-matched controls. Chi-square analysis and multivariate conditional logistic regression were carried out to assess maternal and infant factors (including maternal age, marital status, education, T1DM, hypertension, birth order, delivery method, gestational age, size-for-gestational-age, and birth weight). Results. Cases of T1DM were more likely to be large-for-gestational-age (P=0.024) and delivered by C-section (P=0.009) as compared to controls. C-section delivery was associated with increased risk of T1DM (HR 1.41, P=0.015) when birth weight and gestational age were included in the model, but not when size-for-gestational-age was included (HR 1.3, P=0.076). Conclusions. Birth by C-section was found to be a risk factor for the development of T1DM in a region with high rates of T1DM and birth by C-section. These findings may have an impact on health practice, health care planning, and future research. Article in Journal/Newspaper Newfoundland Hindawi Publishing Corporation Canada Newfoundland Journal of Environmental and Public Health 2012 1 6 |
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Objectives. Newfoundland and Labrador (NL) has one of the highest incidences of Type 1 diabetes mellitus (T1DM) worldwide. Rates of T1DM are increasing and the search for environmental factors that may be contributing to this increase is continuing. Methods. This was a population-based case control design involving the linkage of data from a diabetes database with live birth registration data. 266 children aged 0–15 years with T1DM were compared to age- and gender-matched controls. Chi-square analysis and multivariate conditional logistic regression were carried out to assess maternal and infant factors (including maternal age, marital status, education, T1DM, hypertension, birth order, delivery method, gestational age, size-for-gestational-age, and birth weight). Results. Cases of T1DM were more likely to be large-for-gestational-age (P=0.024) and delivered by C-section (P=0.009) as compared to controls. C-section delivery was associated with increased risk of T1DM (HR 1.41, P=0.015) when birth weight and gestational age were included in the model, but not when size-for-gestational-age was included (HR 1.3, P=0.076). Conclusions. Birth by C-section was found to be a risk factor for the development of T1DM in a region with high rates of T1DM and birth by C-section. These findings may have an impact on health practice, health care planning, and future research. |
format |
Article in Journal/Newspaper |
author |
J. Phillips N. Gill K. Sikdar S. Penney L. A. Newhook |
spellingShingle |
J. Phillips N. Gill K. Sikdar S. Penney L. A. Newhook History of Cesarean Section Associated with Childhood Onset of T1DM in Newfoundland and Labrador, Canada |
author_facet |
J. Phillips N. Gill K. Sikdar S. Penney L. A. Newhook |
author_sort |
J. Phillips |
title |
History of Cesarean Section Associated with Childhood Onset of T1DM in Newfoundland and Labrador, Canada |
title_short |
History of Cesarean Section Associated with Childhood Onset of T1DM in Newfoundland and Labrador, Canada |
title_full |
History of Cesarean Section Associated with Childhood Onset of T1DM in Newfoundland and Labrador, Canada |
title_fullStr |
History of Cesarean Section Associated with Childhood Onset of T1DM in Newfoundland and Labrador, Canada |
title_full_unstemmed |
History of Cesarean Section Associated with Childhood Onset of T1DM in Newfoundland and Labrador, Canada |
title_sort |
history of cesarean section associated with childhood onset of t1dm in newfoundland and labrador, canada |
publisher |
Journal of Environmental and Public Health |
publishDate |
2012 |
url |
https://doi.org/10.1155/2012/635097 |
geographic |
Canada Newfoundland |
geographic_facet |
Canada Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
https://doi.org/10.1155/2012/635097 |
op_rights |
Copyright © 2012 J. Phillips et al. |
op_doi |
https://doi.org/10.1155/2012/635097 |
container_title |
Journal of Environmental and Public Health |
container_volume |
2012 |
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1 |
op_container_end_page |
6 |
_version_ |
1766106996964065280 |