Oxidative Stress and Bioindicators of Reproductive Function in Pulp and Paper Mill Effluent Exposed White Sucker
This study investigates oxidative stress and bioindicators of reproductive function in wild white sucker ( Catostomus commersoni ) collected from environments receiving pulp and paper mill effluent discharges in northern Ontario. Samples were collected over an eight year period adjacent to three pul...
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fthighwire:oai:open-archive.highwire.org:toxsci:kfg114v1 2023-05-15T17:13:15+02:00 Oxidative Stress and Bioindicators of Reproductive Function in Pulp and Paper Mill Effluent Exposed White Sucker Oakes, Ken D. McMaster, Mark E. Pryce, Andrea C. Munkittrick, Kelly R. Portt, Cam B. Hewitt, L. Mark MacLean, Dan D. Van Der Kraak, Glen J. 2003-05-02 13:08:06.0 text/html http://toxsci.oxfordjournals.org/cgi/content/short/kfg114v1 https://doi.org/10.1093/toxsci/kfg114 en eng Oxford University Press http://toxsci.oxfordjournals.org/cgi/content/short/kfg114v1 http://dx.doi.org/10.1093/toxsci/kfg114 Copyright (C) 2003, Society of Toxicology Environmental Toxicology TEXT 2003 fthighwire https://doi.org/10.1093/toxsci/kfg114 2013-05-26T13:18:16Z This study investigates oxidative stress and bioindicators of reproductive function in wild white sucker ( Catostomus commersoni ) collected from environments receiving pulp and paper mill effluent discharges in northern Ontario. Samples were collected over an eight year period adjacent to three pulp and paper mills using a variety of processing and bleaching techniques. Fish collected downstream of pulp and paper mills within the Moose River basin exhibited elevated hepatic and gonadal 2-thiobarbituric acid reactive substances (TBARS), the presence of which is indicative of oxidative stress in these tissues. Within the Jackfish Bay system, exposure to pulp and paper mill effluent did not elevate hepatic or gonadal TBARS. Hepatic cytochrome P4501A activity (CYP1A) and fatty acyl-CoA oxidase (FAO) activities were frequently increased in livers of Moose River basin fish exposed to pulp and paper mill effluent, while lower activities of both enzymes were found within fish from the Jackfish Bay system. This suggests that oxidative stress may be related to CYP1A and FAO activities. Within the Moose River system, increases in measures of oxidative stress (TBARS, FAO) were generally co-incident with decreased levels of 17 ß-estradiol; however, testosterone was often lower in Jackfish Bay system fish without any commensurate changes in oxidative stress. The suite of reproductive and oxidative stress parameters measured in this study varied between seasons and mills suggesting responses to effluent are dynamic and effects are complicated by different receiving environments. The relationship between gonad size, gonadal oxidative stress, and circulating plasma steroids remains unclear. Text Moose River HighWire Press (Stanford University) Jackfish ENVELOPE(-110.902,-110.902,58.434,58.434) Jackfish Bay ENVELOPE(-135.154,-135.154,61.023,61.023) Moose River ENVELOPE(-81.281,-81.281,50.810,50.810) Toxicological Sciences 74 1 51 65 |
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Open Polar |
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HighWire Press (Stanford University) |
op_collection_id |
fthighwire |
language |
English |
topic |
Environmental Toxicology |
spellingShingle |
Environmental Toxicology Oakes, Ken D. McMaster, Mark E. Pryce, Andrea C. Munkittrick, Kelly R. Portt, Cam B. Hewitt, L. Mark MacLean, Dan D. Van Der Kraak, Glen J. Oxidative Stress and Bioindicators of Reproductive Function in Pulp and Paper Mill Effluent Exposed White Sucker |
topic_facet |
Environmental Toxicology |
description |
This study investigates oxidative stress and bioindicators of reproductive function in wild white sucker ( Catostomus commersoni ) collected from environments receiving pulp and paper mill effluent discharges in northern Ontario. Samples were collected over an eight year period adjacent to three pulp and paper mills using a variety of processing and bleaching techniques. Fish collected downstream of pulp and paper mills within the Moose River basin exhibited elevated hepatic and gonadal 2-thiobarbituric acid reactive substances (TBARS), the presence of which is indicative of oxidative stress in these tissues. Within the Jackfish Bay system, exposure to pulp and paper mill effluent did not elevate hepatic or gonadal TBARS. Hepatic cytochrome P4501A activity (CYP1A) and fatty acyl-CoA oxidase (FAO) activities were frequently increased in livers of Moose River basin fish exposed to pulp and paper mill effluent, while lower activities of both enzymes were found within fish from the Jackfish Bay system. This suggests that oxidative stress may be related to CYP1A and FAO activities. Within the Moose River system, increases in measures of oxidative stress (TBARS, FAO) were generally co-incident with decreased levels of 17 ß-estradiol; however, testosterone was often lower in Jackfish Bay system fish without any commensurate changes in oxidative stress. The suite of reproductive and oxidative stress parameters measured in this study varied between seasons and mills suggesting responses to effluent are dynamic and effects are complicated by different receiving environments. The relationship between gonad size, gonadal oxidative stress, and circulating plasma steroids remains unclear. |
format |
Text |
author |
Oakes, Ken D. McMaster, Mark E. Pryce, Andrea C. Munkittrick, Kelly R. Portt, Cam B. Hewitt, L. Mark MacLean, Dan D. Van Der Kraak, Glen J. |
author_facet |
Oakes, Ken D. McMaster, Mark E. Pryce, Andrea C. Munkittrick, Kelly R. Portt, Cam B. Hewitt, L. Mark MacLean, Dan D. Van Der Kraak, Glen J. |
author_sort |
Oakes, Ken D. |
title |
Oxidative Stress and Bioindicators of Reproductive Function in Pulp and Paper Mill Effluent Exposed White Sucker |
title_short |
Oxidative Stress and Bioindicators of Reproductive Function in Pulp and Paper Mill Effluent Exposed White Sucker |
title_full |
Oxidative Stress and Bioindicators of Reproductive Function in Pulp and Paper Mill Effluent Exposed White Sucker |
title_fullStr |
Oxidative Stress and Bioindicators of Reproductive Function in Pulp and Paper Mill Effluent Exposed White Sucker |
title_full_unstemmed |
Oxidative Stress and Bioindicators of Reproductive Function in Pulp and Paper Mill Effluent Exposed White Sucker |
title_sort |
oxidative stress and bioindicators of reproductive function in pulp and paper mill effluent exposed white sucker |
publisher |
Oxford University Press |
publishDate |
2003 |
url |
http://toxsci.oxfordjournals.org/cgi/content/short/kfg114v1 https://doi.org/10.1093/toxsci/kfg114 |
long_lat |
ENVELOPE(-110.902,-110.902,58.434,58.434) ENVELOPE(-135.154,-135.154,61.023,61.023) ENVELOPE(-81.281,-81.281,50.810,50.810) |
geographic |
Jackfish Jackfish Bay Moose River |
geographic_facet |
Jackfish Jackfish Bay Moose River |
genre |
Moose River |
genre_facet |
Moose River |
op_relation |
http://toxsci.oxfordjournals.org/cgi/content/short/kfg114v1 http://dx.doi.org/10.1093/toxsci/kfg114 |
op_rights |
Copyright (C) 2003, Society of Toxicology |
op_doi |
https://doi.org/10.1093/toxsci/kfg114 |
container_title |
Toxicological Sciences |
container_volume |
74 |
container_issue |
1 |
container_start_page |
51 |
op_container_end_page |
65 |
_version_ |
1766070207562907648 |