Induction of Epidermal and Hepatic Ornithine Decarboxylase by a Prudhoe Bay Crude Oil

• Published in: Toxicological Sciences
• Main Authors: RAHIMTULA, A. D., LEE, Y.-Z., SILVA, J.
• Format: Text
• Language: English
• Published: Oxford University Press 1987
• Subjects: Articles; Prudhoe Bay
• Online Access: http://toxsci.oxfordjournals.org/cgi/content/short/8/3/408; https://doi.org/10.1093/toxsci/8.3.408

Induction of Epidermal and Hepatic Ornithine Decarboxylase by a Prudhoe Bay Crude Oil. RAHIMTULA, A. D., LEE, Y.-Z. and SILVA, J. (1987). Fundam. Appl. Toxicol . 8 , 408–414. Application of a Prudhoe Bay crude oil (PBCO) to the backs of mice caused a rapid induction of epidermal ornithine decarboxylase (ODC). A maximum induction of over 60-fold was seen at 6 hr after ap plication of 50 μl of PBCO. Concurrently, epidermal putrescine levels were elevated 4.7-fold over controls. Intraperitoneal administration of PBCO led to a 15-20-fold increase in hepatic ODC activity but to a 45% decrease in the renal enzyme activity. Maximum induction of ODC was seen at 12 hr following the administration of 4 ml/kg body wt of PBCO. Hepatic putrescine levels were elevated 34-fold over controls. Pretreatment of mice with the protein synthesis inhibitor cycloheximide abolished both epidermal and hepatic ODC induction.