An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis

• Published in: Rheumatology
• Main Authors: Jiang, Xia, Källberg, Henrik, Chen, Zuomei, Ärlestig, Lisbeth, Rantapää-Dahlqvist, Solbritt, Davila, Sonia, Klareskog, Lars, Padyukov, Leonid, Alfredsson, Lars
• Format: Text
• Language: English
• Published: Oxford University Press 2016
• Subjects: BASIC AND TRANSLATIONAL SCIENCE; Eira; Northern Sweden
• Online Access: http://rheumatology.oxfordjournals.org/cgi/content/short/55/1/149; https://doi.org/10.1093/rheumatology/kev285

Objective. To investigate the gene–environment interaction between smoking and single nucleotide polymorphisms (SNPs), using Immunochip material, on the risk of developing either of two serologically defined subsets of RA. Methods. Interaction between smoking and 133 648 genetic markers from the Imm...