The epidemiology of Wegener's granulomatosis and microscopic polyangiitis in a Southern Hemisphere region
Objective . To determine the prevalence of Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) in the province of Canterbury, New Zealand. Method . Three hospital clinical databases and the immunology laboratory database were searched and case notes reviewed for patients fulfilling...
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fthighwire:oai:open-archive.highwire.org:rheumatology:45/5/624 2023-05-15T17:43:39+02:00 The epidemiology of Wegener's granulomatosis and microscopic polyangiitis in a Southern Hemisphere region Gibson, A. Stamp, L. K. Chapman, P. T. O'Donnell, J. L. 2006-05-01 00:00:00.0 text/html http://rheumatology.oxfordjournals.org/cgi/content/short/45/5/624 https://doi.org/10.1093/rheumatology/kei259 en eng Oxford University Press http://rheumatology.oxfordjournals.org/cgi/content/short/45/5/624 http://dx.doi.org/10.1093/rheumatology/kei259 Copyright (C) 2006, British Society for Rheumatology CLINICAL TEXT 2006 fthighwire https://doi.org/10.1093/rheumatology/kei259 2007-06-24T13:41:00Z Objective . To determine the prevalence of Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) in the province of Canterbury, New Zealand. Method . Three hospital clinical databases and the immunology laboratory database were searched and case notes reviewed for patients fulfilling either the 1990 American College of Rheumatology (ACR) criteria for WG or a modification of those criteria that allowed for antineutrophil cytoplasmic antibody (ANCA) positivity in the absence of granulomatous vasculitis. MPA was defined by the Chapel Hill consensus definition; however, in the absence of histological evidence of pauci-immune glomerulonephritis, ANCA positivity in association with evidence of active glomerular disease was included as a criterion. The point prevalence at 31 December 2003 and the 5-yr period prevalence for the interval 1 January 1999 to 31 December 2003 were calculated. Results . Seventy-three patients with WG and 28 patients with MPA fulfilled the inclusion criteria. A 5-yr period prevalence of 152 WG cases/million [95% confidence interval (CI) 117–186] and 58 MPA cases/million (95% CI 37–80) was calculated using 2001 census data as denominator. Nineteen patients with WG died and 10 patients with MPA died during the study period, resulting in a point prevalence for survivors at 31 December 2003 of 112 cases/million (95% CI 82–142) and 37 cases/million (95% CI 20–55), respectively. Using unmodified ACR criteria the 5-yr period and point prevalence for WG were 131/million (95% CI 99–163) and 93.5/million (95% CI 66–121), respectively. Apart from respiratory tract involvement, which formed part of the case definition of WG, organ involvement was similar in both diseases. Conclusion. The prevalence of WG and MPA in Canterbury is the highest reported to date. Restricting the case definition of WG to the ACR classification criteria we found a prevalence equivalent to that described in northern Norway. The clinical severity and serological characteristics were similar to descriptions in other WG ... Text Northern Norway HighWire Press (Stanford University) Chapel Hill ENVELOPE(-57.976,-57.976,-63.685,-63.685) New Zealand Norway Rheumatology 45 5 624 628 |
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HighWire Press (Stanford University) |
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English |
topic |
CLINICAL |
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CLINICAL Gibson, A. Stamp, L. K. Chapman, P. T. O'Donnell, J. L. The epidemiology of Wegener's granulomatosis and microscopic polyangiitis in a Southern Hemisphere region |
topic_facet |
CLINICAL |
description |
Objective . To determine the prevalence of Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) in the province of Canterbury, New Zealand. Method . Three hospital clinical databases and the immunology laboratory database were searched and case notes reviewed for patients fulfilling either the 1990 American College of Rheumatology (ACR) criteria for WG or a modification of those criteria that allowed for antineutrophil cytoplasmic antibody (ANCA) positivity in the absence of granulomatous vasculitis. MPA was defined by the Chapel Hill consensus definition; however, in the absence of histological evidence of pauci-immune glomerulonephritis, ANCA positivity in association with evidence of active glomerular disease was included as a criterion. The point prevalence at 31 December 2003 and the 5-yr period prevalence for the interval 1 January 1999 to 31 December 2003 were calculated. Results . Seventy-three patients with WG and 28 patients with MPA fulfilled the inclusion criteria. A 5-yr period prevalence of 152 WG cases/million [95% confidence interval (CI) 117–186] and 58 MPA cases/million (95% CI 37–80) was calculated using 2001 census data as denominator. Nineteen patients with WG died and 10 patients with MPA died during the study period, resulting in a point prevalence for survivors at 31 December 2003 of 112 cases/million (95% CI 82–142) and 37 cases/million (95% CI 20–55), respectively. Using unmodified ACR criteria the 5-yr period and point prevalence for WG were 131/million (95% CI 99–163) and 93.5/million (95% CI 66–121), respectively. Apart from respiratory tract involvement, which formed part of the case definition of WG, organ involvement was similar in both diseases. Conclusion. The prevalence of WG and MPA in Canterbury is the highest reported to date. Restricting the case definition of WG to the ACR classification criteria we found a prevalence equivalent to that described in northern Norway. The clinical severity and serological characteristics were similar to descriptions in other WG ... |
format |
Text |
author |
Gibson, A. Stamp, L. K. Chapman, P. T. O'Donnell, J. L. |
author_facet |
Gibson, A. Stamp, L. K. Chapman, P. T. O'Donnell, J. L. |
author_sort |
Gibson, A. |
title |
The epidemiology of Wegener's granulomatosis and microscopic polyangiitis in a Southern Hemisphere region |
title_short |
The epidemiology of Wegener's granulomatosis and microscopic polyangiitis in a Southern Hemisphere region |
title_full |
The epidemiology of Wegener's granulomatosis and microscopic polyangiitis in a Southern Hemisphere region |
title_fullStr |
The epidemiology of Wegener's granulomatosis and microscopic polyangiitis in a Southern Hemisphere region |
title_full_unstemmed |
The epidemiology of Wegener's granulomatosis and microscopic polyangiitis in a Southern Hemisphere region |
title_sort |
epidemiology of wegener's granulomatosis and microscopic polyangiitis in a southern hemisphere region |
publisher |
Oxford University Press |
publishDate |
2006 |
url |
http://rheumatology.oxfordjournals.org/cgi/content/short/45/5/624 https://doi.org/10.1093/rheumatology/kei259 |
long_lat |
ENVELOPE(-57.976,-57.976,-63.685,-63.685) |
geographic |
Chapel Hill New Zealand Norway |
geographic_facet |
Chapel Hill New Zealand Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_relation |
http://rheumatology.oxfordjournals.org/cgi/content/short/45/5/624 http://dx.doi.org/10.1093/rheumatology/kei259 |
op_rights |
Copyright (C) 2006, British Society for Rheumatology |
op_doi |
https://doi.org/10.1093/rheumatology/kei259 |
container_title |
Rheumatology |
container_volume |
45 |
container_issue |
5 |
container_start_page |
624 |
op_container_end_page |
628 |
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1766145788722806784 |