The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease
It has long been recognized from epidemiological studies that Greenland Eskimos have substantially reduced rates of acute myocardial infarction (MI) compared with Western controls. From these epidemiological observations, the benefits of fatty fish consumption have been explored in cell culture and...
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2003
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fthighwire:oai:open-archive.highwire.org:qjmed:96/7/465 2023-05-15T16:07:22+02:00 The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease Lee, K.W. Lip, G.Y.H. 2003-07-01 00:00:00.0 text/html http://qjmed.oxfordjournals.org/cgi/content/short/96/7/465 https://doi.org/10.1093/qjmed/hcg092 en eng Oxford University Press http://qjmed.oxfordjournals.org/cgi/content/short/96/7/465 http://dx.doi.org/10.1093/qjmed/hcg092 Copyright (C) 2003, Association of Physicians Reviews TEXT 2003 fthighwire https://doi.org/10.1093/qjmed/hcg092 2016-11-16T17:36:53Z It has long been recognized from epidemiological studies that Greenland Eskimos have substantially reduced rates of acute myocardial infarction (MI) compared with Western controls. From these epidemiological observations, the benefits of fatty fish consumption have been explored in cell culture and animal studies, as well as randomized controlled trials investigating the cardioprotective effects of omega-3 fatty acids. Dietary omega-3 fatty acids seem to stabilize the myocardium electrically, resulting in reduced susceptibility to ventricular arrhythmias, thereby reducing the risk of sudden death. These fatty acids also have potent anti-inflammatory effects, and may also be antithrombotic and anti-atherogenic. Furthermore, the recent GISSI-Prevention study of 11 324 patients showed a marked decrease in risk of sudden cardiac death as well as a reduction in all-cause mortality in the group taking a highly purified form of omega-3 fatty acids, despite the use of other secondary prevention drugs, including beta-blockers and lipid-lowering therapy. The use of omega-3 fatty acids should be considered as part of a comprehensive secondary prevention strategy post-myocardial infarction. Text eskimo* Greenland HighWire Press (Stanford University) Greenland QJM 96 7 465 480 |
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Reviews Lee, K.W. Lip, G.Y.H. The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease |
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Reviews |
description |
It has long been recognized from epidemiological studies that Greenland Eskimos have substantially reduced rates of acute myocardial infarction (MI) compared with Western controls. From these epidemiological observations, the benefits of fatty fish consumption have been explored in cell culture and animal studies, as well as randomized controlled trials investigating the cardioprotective effects of omega-3 fatty acids. Dietary omega-3 fatty acids seem to stabilize the myocardium electrically, resulting in reduced susceptibility to ventricular arrhythmias, thereby reducing the risk of sudden death. These fatty acids also have potent anti-inflammatory effects, and may also be antithrombotic and anti-atherogenic. Furthermore, the recent GISSI-Prevention study of 11 324 patients showed a marked decrease in risk of sudden cardiac death as well as a reduction in all-cause mortality in the group taking a highly purified form of omega-3 fatty acids, despite the use of other secondary prevention drugs, including beta-blockers and lipid-lowering therapy. The use of omega-3 fatty acids should be considered as part of a comprehensive secondary prevention strategy post-myocardial infarction. |
format |
Text |
author |
Lee, K.W. Lip, G.Y.H. |
author_facet |
Lee, K.W. Lip, G.Y.H. |
author_sort |
Lee, K.W. |
title |
The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease |
title_short |
The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease |
title_full |
The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease |
title_fullStr |
The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease |
title_full_unstemmed |
The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease |
title_sort |
role of omega-3 fatty acids in the secondary prevention of cardiovascular disease |
publisher |
Oxford University Press |
publishDate |
2003 |
url |
http://qjmed.oxfordjournals.org/cgi/content/short/96/7/465 https://doi.org/10.1093/qjmed/hcg092 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland |
genre_facet |
eskimo* Greenland |
op_relation |
http://qjmed.oxfordjournals.org/cgi/content/short/96/7/465 http://dx.doi.org/10.1093/qjmed/hcg092 |
op_rights |
Copyright (C) 2003, Association of Physicians |
op_doi |
https://doi.org/10.1093/qjmed/hcg092 |
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QJM |
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96 |
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7 |
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465 |
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480 |
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1766403455043239936 |