Glucose metabolism in midlife predicts participation in working life: a Northern Finland Birth Cohort 1966 study
Objective To evaluate how clinically measured glucose metabolism categories predict registered participation in working life. Methods In the 46-year follow-up of Northern Finland Birth Cohort 1966 (n=5328, 2342 men and 2986 women), we used oral glucose tolerance tests, surveys and glycated haemoglob...
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fthighwire:oai:open-archive.highwire.org:oemed:77/5/324 2023-05-15T17:42:23+02:00 Glucose metabolism in midlife predicts participation in working life: a Northern Finland Birth Cohort 1966 study Varanka-Ruuska, Tuulia Tolvanen, Mimmi Vaaramo, Eeva Keinänen-Kiukaanniemi, Sirkka Sebert, Sylvain Rautio, Nina Ala-Mursula, Leena 2020-05-01 00:00:00.0 text/html http://oem.bmj.com/cgi/content/short/77/5/324 https://doi.org/10.1136/oemed-2019-106170 en eng BMJ Publishing Group Ltd http://oem.bmj.com/cgi/content/short/77/5/324 http://dx.doi.org/10.1136/oemed-2019-106170 Copyright (C) 2020, BMJ Publishing Group Ltd Workplace TEXT 2020 fthighwire https://doi.org/10.1136/oemed-2019-106170 2020-04-25T10:49:33Z Objective To evaluate how clinically measured glucose metabolism categories predict registered participation in working life. Methods In the 46-year follow-up of Northern Finland Birth Cohort 1966 (n=5328, 2342 men and 2986 women), we used oral glucose tolerance tests, surveys and glycated haemoglobin to determine glucose metabolism categorised as normal, pre-diabetes, screen-detected and previous type 2 diabetes (T2D). Consequent participation in working life during the 2-year follow-up period was measured as registered disability, unemployment and employment days, for which incidence rate ratios (IRRs) with 95% CIs were calculated using Poisson regression, adjusted for baseline employment and socioeconomic, health-related and behavioural factors. Results In comparison to normal glucose, all categories of impaired glucose metabolism were associated with poorer participation in working life in the unadjusted models. After adjustments, the risks (IRR (95% CI)) of disability days remained heightened by both screen-detected and previous T2D among men (1.3 (1.3 to 1.4) and 1.5 (1.4 to 1.5), respectively), whereas among women the risks were lowered (0.9 (0.8 to 0.9) and 0.9 (0.9 to 1.0), respectively). The risks of unemployment were consistently higher in all categories of impaired glucose metabolism, and were the highest among women with previous T2D (1.6 (1.5 to 1.6)). Correspondingly, the rates of total employment days were lower in relation to screen-detected T2D among men and women (5% and 6%, respectively), and previous T2D (6% and 3%). Conclusions Overall, impaired glucose metabolism associated with deteriorated working life participation already in middle age. The high prevalence of impaired glucose metabolism emphasises the need for actions to support sustainable working careers. Text Northern Finland HighWire Press (Stanford University) Occupational and Environmental Medicine 77 5 324 332 |
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Workplace Varanka-Ruuska, Tuulia Tolvanen, Mimmi Vaaramo, Eeva Keinänen-Kiukaanniemi, Sirkka Sebert, Sylvain Rautio, Nina Ala-Mursula, Leena Glucose metabolism in midlife predicts participation in working life: a Northern Finland Birth Cohort 1966 study |
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Workplace |
description |
Objective To evaluate how clinically measured glucose metabolism categories predict registered participation in working life. Methods In the 46-year follow-up of Northern Finland Birth Cohort 1966 (n=5328, 2342 men and 2986 women), we used oral glucose tolerance tests, surveys and glycated haemoglobin to determine glucose metabolism categorised as normal, pre-diabetes, screen-detected and previous type 2 diabetes (T2D). Consequent participation in working life during the 2-year follow-up period was measured as registered disability, unemployment and employment days, for which incidence rate ratios (IRRs) with 95% CIs were calculated using Poisson regression, adjusted for baseline employment and socioeconomic, health-related and behavioural factors. Results In comparison to normal glucose, all categories of impaired glucose metabolism were associated with poorer participation in working life in the unadjusted models. After adjustments, the risks (IRR (95% CI)) of disability days remained heightened by both screen-detected and previous T2D among men (1.3 (1.3 to 1.4) and 1.5 (1.4 to 1.5), respectively), whereas among women the risks were lowered (0.9 (0.8 to 0.9) and 0.9 (0.9 to 1.0), respectively). The risks of unemployment were consistently higher in all categories of impaired glucose metabolism, and were the highest among women with previous T2D (1.6 (1.5 to 1.6)). Correspondingly, the rates of total employment days were lower in relation to screen-detected T2D among men and women (5% and 6%, respectively), and previous T2D (6% and 3%). Conclusions Overall, impaired glucose metabolism associated with deteriorated working life participation already in middle age. The high prevalence of impaired glucose metabolism emphasises the need for actions to support sustainable working careers. |
format |
Text |
author |
Varanka-Ruuska, Tuulia Tolvanen, Mimmi Vaaramo, Eeva Keinänen-Kiukaanniemi, Sirkka Sebert, Sylvain Rautio, Nina Ala-Mursula, Leena |
author_facet |
Varanka-Ruuska, Tuulia Tolvanen, Mimmi Vaaramo, Eeva Keinänen-Kiukaanniemi, Sirkka Sebert, Sylvain Rautio, Nina Ala-Mursula, Leena |
author_sort |
Varanka-Ruuska, Tuulia |
title |
Glucose metabolism in midlife predicts participation in working life: a Northern Finland Birth Cohort 1966 study |
title_short |
Glucose metabolism in midlife predicts participation in working life: a Northern Finland Birth Cohort 1966 study |
title_full |
Glucose metabolism in midlife predicts participation in working life: a Northern Finland Birth Cohort 1966 study |
title_fullStr |
Glucose metabolism in midlife predicts participation in working life: a Northern Finland Birth Cohort 1966 study |
title_full_unstemmed |
Glucose metabolism in midlife predicts participation in working life: a Northern Finland Birth Cohort 1966 study |
title_sort |
glucose metabolism in midlife predicts participation in working life: a northern finland birth cohort 1966 study |
publisher |
BMJ Publishing Group Ltd |
publishDate |
2020 |
url |
http://oem.bmj.com/cgi/content/short/77/5/324 https://doi.org/10.1136/oemed-2019-106170 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://oem.bmj.com/cgi/content/short/77/5/324 http://dx.doi.org/10.1136/oemed-2019-106170 |
op_rights |
Copyright (C) 2020, BMJ Publishing Group Ltd |
op_doi |
https://doi.org/10.1136/oemed-2019-106170 |
container_title |
Occupational and Environmental Medicine |
container_volume |
77 |
container_issue |
5 |
container_start_page |
324 |
op_container_end_page |
332 |
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1766144229120147456 |