Three Neuropeptide Y Receptor Genes in the Spiny Dogfish, Squalus acanthias, Support en Bloc Duplications in Early Vertebrate Evolution
It has been debated whether the increase in gene number during early vertebrate evolution was due to multiple independent gene duplications or synchronous duplications of many genes. We describe here the cloning of three neuropeptide Y (NPY) receptor genes belonging to the Y1 subfamily in the spiny...
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fthighwire:oai:open-archive.highwire.org:molbiolevol:20/8/1271 2023-05-15T18:51:06+02:00 Three Neuropeptide Y Receptor Genes in the Spiny Dogfish, Squalus acanthias, Support en Bloc Duplications in Early Vertebrate Evolution Salaneck, Erik Ardell, David H. Larson, Earl T. Larhammar, Dan 2003-08-01 00:00:00.0 text/html http://mbe.oxfordjournals.org/cgi/content/short/20/8/1271 https://doi.org/10.1093/molbev/msg133 en eng Oxford University Press http://mbe.oxfordjournals.org/cgi/content/short/20/8/1271 http://dx.doi.org/10.1093/molbev/msg133 Copyright (C) 2003, Society for Molecular Biology and Evolution Original Articles TEXT 2003 fthighwire https://doi.org/10.1093/molbev/msg133 2007-06-24T16:34:44Z It has been debated whether the increase in gene number during early vertebrate evolution was due to multiple independent gene duplications or synchronous duplications of many genes. We describe here the cloning of three neuropeptide Y (NPY) receptor genes belonging to the Y1 subfamily in the spiny dogfish, Squalus acanthias , a cartilaginous fish. The three genes are orthologs of the mammalian subtypes Y1, Y4, and Y6, which are located in paralogous gene regions on different chromosomes in mammals. Thus, these genes arose by duplications of a chromosome region before the radiation of gnathostomes (jawed vertebrates). Estimates of duplication times from linearized trees together with evidence from other gene families supports two rounds of chromosome duplications or tetraploidizations early in vertebrate evolution. The anatomical distribution of mRNA was determined by reverse-transcriptase PCR and was found to differ from mammals, suggesting differential functional diversification of the new gene copies during the radiation of the vertebrate classes. Text spiny dogfish Squalus acanthias HighWire Press (Stanford University) Molecular Biology and Evolution 20 8 1271 1280 |
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English |
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Original Articles |
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Original Articles Salaneck, Erik Ardell, David H. Larson, Earl T. Larhammar, Dan Three Neuropeptide Y Receptor Genes in the Spiny Dogfish, Squalus acanthias, Support en Bloc Duplications in Early Vertebrate Evolution |
topic_facet |
Original Articles |
description |
It has been debated whether the increase in gene number during early vertebrate evolution was due to multiple independent gene duplications or synchronous duplications of many genes. We describe here the cloning of three neuropeptide Y (NPY) receptor genes belonging to the Y1 subfamily in the spiny dogfish, Squalus acanthias , a cartilaginous fish. The three genes are orthologs of the mammalian subtypes Y1, Y4, and Y6, which are located in paralogous gene regions on different chromosomes in mammals. Thus, these genes arose by duplications of a chromosome region before the radiation of gnathostomes (jawed vertebrates). Estimates of duplication times from linearized trees together with evidence from other gene families supports two rounds of chromosome duplications or tetraploidizations early in vertebrate evolution. The anatomical distribution of mRNA was determined by reverse-transcriptase PCR and was found to differ from mammals, suggesting differential functional diversification of the new gene copies during the radiation of the vertebrate classes. |
format |
Text |
author |
Salaneck, Erik Ardell, David H. Larson, Earl T. Larhammar, Dan |
author_facet |
Salaneck, Erik Ardell, David H. Larson, Earl T. Larhammar, Dan |
author_sort |
Salaneck, Erik |
title |
Three Neuropeptide Y Receptor Genes in the Spiny Dogfish, Squalus acanthias, Support en Bloc Duplications in Early Vertebrate Evolution |
title_short |
Three Neuropeptide Y Receptor Genes in the Spiny Dogfish, Squalus acanthias, Support en Bloc Duplications in Early Vertebrate Evolution |
title_full |
Three Neuropeptide Y Receptor Genes in the Spiny Dogfish, Squalus acanthias, Support en Bloc Duplications in Early Vertebrate Evolution |
title_fullStr |
Three Neuropeptide Y Receptor Genes in the Spiny Dogfish, Squalus acanthias, Support en Bloc Duplications in Early Vertebrate Evolution |
title_full_unstemmed |
Three Neuropeptide Y Receptor Genes in the Spiny Dogfish, Squalus acanthias, Support en Bloc Duplications in Early Vertebrate Evolution |
title_sort |
three neuropeptide y receptor genes in the spiny dogfish, squalus acanthias, support en bloc duplications in early vertebrate evolution |
publisher |
Oxford University Press |
publishDate |
2003 |
url |
http://mbe.oxfordjournals.org/cgi/content/short/20/8/1271 https://doi.org/10.1093/molbev/msg133 |
genre |
spiny dogfish Squalus acanthias |
genre_facet |
spiny dogfish Squalus acanthias |
op_relation |
http://mbe.oxfordjournals.org/cgi/content/short/20/8/1271 http://dx.doi.org/10.1093/molbev/msg133 |
op_rights |
Copyright (C) 2003, Society for Molecular Biology and Evolution |
op_doi |
https://doi.org/10.1093/molbev/msg133 |
container_title |
Molecular Biology and Evolution |
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20 |
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8 |
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1271 |
op_container_end_page |
1280 |
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1766244897836236800 |