Prostate Cancer Progression and Survival in BRCA2 Mutation Carriers
Background Mutations in the BRCA2 gene are associated with an increased risk of prostate cancer, but it is not known whether they are associated with progression of the disease. We compared prostate cancer–specific survival, disease stage, and tumor grade between prostate cancer patients carrying th...
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fthighwire:oai:open-archive.highwire.org:jnci:99/12/929 2023-05-15T16:52:29+02:00 Prostate Cancer Progression and Survival in BRCA2 Mutation Carriers Tryggvadóttir, Laufey Vidarsdóttir, Linda Thorgeirsson, Tryggvi Jonasson, Jon Gunnlaugur Ólafsdóttir, Elinborg Jona Ólafsdóttir, Gudridur Helga Rafnar, Thorunn Thorlacius, Steinunn Jonsson, Eirikur Eyfjord, Jorunn Erla Tulinius, Hrafn 2007-06-19 text/html http://jnci.oxfordjournals.org/cgi/content/short/99/12/929 https://doi.org/10.1093/jnci/djm005 en eng Oxford University Press http://jnci.oxfordjournals.org/cgi/content/short/99/12/929 http://dx.doi.org/10.1093/jnci/djm005 Copyright (C) 2007, National Cancer Institute ARTICLES TEXT 2007 fthighwire https://doi.org/10.1093/jnci/djm005 2007-06-24T15:47:22Z Background Mutations in the BRCA2 gene are associated with an increased risk of prostate cancer, but it is not known whether they are associated with progression of the disease. We compared prostate cancer–specific survival, disease stage, and tumor grade between prostate cancer patients carrying the Icelandic BRCA2 999del5 founder mutation and noncarriers. Methods Using population-based registries, we identified all 596 prostate cancer patients who were diagnosed in Iceland during 1955 through 2004 among 29603 male relatives of unselected breast cancer probands. BRCA2 mutation status could be determined for 527 patients (88.4%). Stage and grade were abstracted from original records, blindly with respect to mutation status, for a subgroup of 89 patients that included all mutation carriers and, for each carrier, two control patients without the BRCA2 999del5 mutation who were matched to the carrier on years of diagnosis and birth. Hazard ratios (HRs) and 95% confidence intervals (CIs) for prostate cancer–specific survival were estimated using multivariable regression models. All statistical tests were two-sided. Results The mutation was carried by 30 patients (5.7%). Compared with noncarriers, BRCA2 999del5 mutation carriers had a lower mean age at diagnosis (69.0 years versus 74.0 years; P = .002), more advanced tumor stage (stages 3 or 4, 79.3% versus 38.6%; P <.001), higher tumor grade (grades G3–4, 84.0% versus 52.7%, P = .007), and shorter median survival time (2.1 years, 95% CI = 1.4 to 3.6 years, versus 12.4 years, 95% CI = 9.9 to 19.7 years). Carrying the BRCA2 999del5 mutation was also associated with an increased risk of dying from prostate cancer (adjusting for year of diagnosis and birth, HR = 3.42, 95% CI = 2.12 to 5.51); the association remained after adjustment for stage and grade (HR = 2.35, 95% CI = 1.08 to 5.11). The prognosis of BRCA2 999del5 mutation carriers was not associated with period of diagnosis or with relatedness to breast cancer probands. Conclusions The Icelandic BRCA2 999del5 ... Text Iceland HighWire Press (Stanford University) JNCI Journal of the National Cancer Institute 99 12 929 935 |
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ARTICLES Tryggvadóttir, Laufey Vidarsdóttir, Linda Thorgeirsson, Tryggvi Jonasson, Jon Gunnlaugur Ólafsdóttir, Elinborg Jona Ólafsdóttir, Gudridur Helga Rafnar, Thorunn Thorlacius, Steinunn Jonsson, Eirikur Eyfjord, Jorunn Erla Tulinius, Hrafn Prostate Cancer Progression and Survival in BRCA2 Mutation Carriers |
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Background Mutations in the BRCA2 gene are associated with an increased risk of prostate cancer, but it is not known whether they are associated with progression of the disease. We compared prostate cancer–specific survival, disease stage, and tumor grade between prostate cancer patients carrying the Icelandic BRCA2 999del5 founder mutation and noncarriers. Methods Using population-based registries, we identified all 596 prostate cancer patients who were diagnosed in Iceland during 1955 through 2004 among 29603 male relatives of unselected breast cancer probands. BRCA2 mutation status could be determined for 527 patients (88.4%). Stage and grade were abstracted from original records, blindly with respect to mutation status, for a subgroup of 89 patients that included all mutation carriers and, for each carrier, two control patients without the BRCA2 999del5 mutation who were matched to the carrier on years of diagnosis and birth. Hazard ratios (HRs) and 95% confidence intervals (CIs) for prostate cancer–specific survival were estimated using multivariable regression models. All statistical tests were two-sided. Results The mutation was carried by 30 patients (5.7%). Compared with noncarriers, BRCA2 999del5 mutation carriers had a lower mean age at diagnosis (69.0 years versus 74.0 years; P = .002), more advanced tumor stage (stages 3 or 4, 79.3% versus 38.6%; P <.001), higher tumor grade (grades G3–4, 84.0% versus 52.7%, P = .007), and shorter median survival time (2.1 years, 95% CI = 1.4 to 3.6 years, versus 12.4 years, 95% CI = 9.9 to 19.7 years). Carrying the BRCA2 999del5 mutation was also associated with an increased risk of dying from prostate cancer (adjusting for year of diagnosis and birth, HR = 3.42, 95% CI = 2.12 to 5.51); the association remained after adjustment for stage and grade (HR = 2.35, 95% CI = 1.08 to 5.11). The prognosis of BRCA2 999del5 mutation carriers was not associated with period of diagnosis or with relatedness to breast cancer probands. Conclusions The Icelandic BRCA2 999del5 ... |
format |
Text |
author |
Tryggvadóttir, Laufey Vidarsdóttir, Linda Thorgeirsson, Tryggvi Jonasson, Jon Gunnlaugur Ólafsdóttir, Elinborg Jona Ólafsdóttir, Gudridur Helga Rafnar, Thorunn Thorlacius, Steinunn Jonsson, Eirikur Eyfjord, Jorunn Erla Tulinius, Hrafn |
author_facet |
Tryggvadóttir, Laufey Vidarsdóttir, Linda Thorgeirsson, Tryggvi Jonasson, Jon Gunnlaugur Ólafsdóttir, Elinborg Jona Ólafsdóttir, Gudridur Helga Rafnar, Thorunn Thorlacius, Steinunn Jonsson, Eirikur Eyfjord, Jorunn Erla Tulinius, Hrafn |
author_sort |
Tryggvadóttir, Laufey |
title |
Prostate Cancer Progression and Survival in BRCA2 Mutation Carriers |
title_short |
Prostate Cancer Progression and Survival in BRCA2 Mutation Carriers |
title_full |
Prostate Cancer Progression and Survival in BRCA2 Mutation Carriers |
title_fullStr |
Prostate Cancer Progression and Survival in BRCA2 Mutation Carriers |
title_full_unstemmed |
Prostate Cancer Progression and Survival in BRCA2 Mutation Carriers |
title_sort |
prostate cancer progression and survival in brca2 mutation carriers |
publisher |
Oxford University Press |
publishDate |
2007 |
url |
http://jnci.oxfordjournals.org/cgi/content/short/99/12/929 https://doi.org/10.1093/jnci/djm005 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://jnci.oxfordjournals.org/cgi/content/short/99/12/929 http://dx.doi.org/10.1093/jnci/djm005 |
op_rights |
Copyright (C) 2007, National Cancer Institute |
op_doi |
https://doi.org/10.1093/jnci/djm005 |
container_title |
JNCI Journal of the National Cancer Institute |
container_volume |
99 |
container_issue |
12 |
container_start_page |
929 |
op_container_end_page |
935 |
_version_ |
1766042777393561600 |