Virus-Associated Cancers in Greenland: Frequent Hepatitis B Virus Infection But Low Primary Hepatocellular Carcinoma Incidence
The incidence of primary hepatocellular carcinoma (PHC) in Greenland between 1960 and 1981 was determined and compared with the rate of this disease in Denmark. The annual age and sex rate (per 100,000) was not significantly different (overall, 1.9 vs. 2.2) despite a large difference in the prevalen...
Published in: | JNCI: Journal of the National Cancer Institute |
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Oxford University Press
1984
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fthighwire:oai:open-archive.highwire.org:jnci:73/6/1267 2023-05-15T16:07:05+02:00 Virus-Associated Cancers in Greenland: Frequent Hepatitis B Virus Infection But Low Primary Hepatocellular Carcinoma Incidence Melbye, Mads Skinhèj, Peter Nielsen, Nils Høgaard Vestergaard, Bent Faber Ebbesen, Peter Hansen, Jens P. Hart Biggar, Robert J. 1984-12-01 00:00:00.0 text/html http://jnci.oxfordjournals.org/cgi/content/short/73/6/1267 https://doi.org/10.1093/jnci/73.6.1267 en eng Oxford University Press http://jnci.oxfordjournals.org/cgi/content/short/73/6/1267 http://dx.doi.org/10.1093/jnci/73.6.1267 Copyright (C) 1984, National Cancer Institute Investigations on Man TEXT 1984 fthighwire https://doi.org/10.1093/jnci/73.6.1267 2013-05-26T15:57:15Z The incidence of primary hepatocellular carcinoma (PHC) in Greenland between 1960 and 1981 was determined and compared with the rate of this disease in Denmark. The annual age and sex rate (per 100,000) was not significantly different (overall, 1.9 vs. 2.2) despite a large difference in the prevalence of hepatitis B surface antigen (HBsAg) and anti-HBs markers of hepatitis. On the basis of a recent report of a very strong risk of PHC among male HBsAg carriers, 4.0 cases of PHC per year were expected in male Eskimos, but only 0.2 cases per year were observed. The incidence rates of other cancers suggested to be virally associated, including nasopharyngeal carcinoma, salivary gland cancer, and carcinoma of the cervix, were all high in Greenland compared to rates for the Danish population, and these high incidence rates are in accord with the markedly higher prevalences in Greenland Eskimos of viruses with which these other cancers have been associated. Thus Greenland Eskimos do not have a high incidence of PHC despite a high prevalence of HBsAg carriers, which suggests that other carcinogenic factors in this environment may be absent or that protective factors are present. Text eskimo* Greenland HighWire Press (Stanford University) Greenland JNCI: Journal of the National Cancer Institute |
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HighWire Press (Stanford University) |
op_collection_id |
fthighwire |
language |
English |
topic |
Investigations on Man |
spellingShingle |
Investigations on Man Melbye, Mads Skinhèj, Peter Nielsen, Nils Høgaard Vestergaard, Bent Faber Ebbesen, Peter Hansen, Jens P. Hart Biggar, Robert J. Virus-Associated Cancers in Greenland: Frequent Hepatitis B Virus Infection But Low Primary Hepatocellular Carcinoma Incidence |
topic_facet |
Investigations on Man |
description |
The incidence of primary hepatocellular carcinoma (PHC) in Greenland between 1960 and 1981 was determined and compared with the rate of this disease in Denmark. The annual age and sex rate (per 100,000) was not significantly different (overall, 1.9 vs. 2.2) despite a large difference in the prevalence of hepatitis B surface antigen (HBsAg) and anti-HBs markers of hepatitis. On the basis of a recent report of a very strong risk of PHC among male HBsAg carriers, 4.0 cases of PHC per year were expected in male Eskimos, but only 0.2 cases per year were observed. The incidence rates of other cancers suggested to be virally associated, including nasopharyngeal carcinoma, salivary gland cancer, and carcinoma of the cervix, were all high in Greenland compared to rates for the Danish population, and these high incidence rates are in accord with the markedly higher prevalences in Greenland Eskimos of viruses with which these other cancers have been associated. Thus Greenland Eskimos do not have a high incidence of PHC despite a high prevalence of HBsAg carriers, which suggests that other carcinogenic factors in this environment may be absent or that protective factors are present. |
format |
Text |
author |
Melbye, Mads Skinhèj, Peter Nielsen, Nils Høgaard Vestergaard, Bent Faber Ebbesen, Peter Hansen, Jens P. Hart Biggar, Robert J. |
author_facet |
Melbye, Mads Skinhèj, Peter Nielsen, Nils Høgaard Vestergaard, Bent Faber Ebbesen, Peter Hansen, Jens P. Hart Biggar, Robert J. |
author_sort |
Melbye, Mads |
title |
Virus-Associated Cancers in Greenland: Frequent Hepatitis B Virus Infection But Low Primary Hepatocellular Carcinoma Incidence |
title_short |
Virus-Associated Cancers in Greenland: Frequent Hepatitis B Virus Infection But Low Primary Hepatocellular Carcinoma Incidence |
title_full |
Virus-Associated Cancers in Greenland: Frequent Hepatitis B Virus Infection But Low Primary Hepatocellular Carcinoma Incidence |
title_fullStr |
Virus-Associated Cancers in Greenland: Frequent Hepatitis B Virus Infection But Low Primary Hepatocellular Carcinoma Incidence |
title_full_unstemmed |
Virus-Associated Cancers in Greenland: Frequent Hepatitis B Virus Infection But Low Primary Hepatocellular Carcinoma Incidence |
title_sort |
virus-associated cancers in greenland: frequent hepatitis b virus infection but low primary hepatocellular carcinoma incidence |
publisher |
Oxford University Press |
publishDate |
1984 |
url |
http://jnci.oxfordjournals.org/cgi/content/short/73/6/1267 https://doi.org/10.1093/jnci/73.6.1267 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland |
genre_facet |
eskimo* Greenland |
op_relation |
http://jnci.oxfordjournals.org/cgi/content/short/73/6/1267 http://dx.doi.org/10.1093/jnci/73.6.1267 |
op_rights |
Copyright (C) 1984, National Cancer Institute |
op_doi |
https://doi.org/10.1093/jnci/73.6.1267 |
container_title |
JNCI: Journal of the National Cancer Institute |
_version_ |
1766403086298906624 |