Genotyping of Pseudohermaphrodite Polar Bears in Nunavut and Advances in DNA Sexing Techniques
Female pseudohermaphroditism is characterized by gonads consistent with chromosomal sex combined with ambiguous, masculinized external genitalia. Recognized in many mammals, this condition results from fetal exposure to androgens that can be embryonic, maternal, or environmental in origin. Female ps...
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fthighwire:oai:open-archive.highwire.org:jmammal:86/1/160 2023-05-15T17:48:00+02:00 Genotyping of Pseudohermaphrodite Polar Bears in Nunavut and Advances in DNA Sexing Techniques Carmichael, Lindsey E. Krizan, Peter Blum, Susan Polischuk Strobeck, Curtis 2005-02-15 00:00:00.0 text/html http://jmammal.oxfordjournals.org/cgi/content/short/86/1/160 https://doi.org/10.1644/1545-1542(2005)086<0160:GOPPBI>2.0.CO;2 en eng Oxford University Press http://jmammal.oxfordjournals.org/cgi/content/short/86/1/160 http://dx.doi.org/10.1644/1545-1542(2005)086<0160:GOPPBI>2.0.CO;2 Copyright (C) 2005, Oxford University Press Feature Articles TEXT 2005 fthighwire https://doi.org/10.1644/1545-1542(2005)086<0160:GOPPBI>2.0.CO;2 2018-04-07T06:26:05Z Female pseudohermaphroditism is characterized by gonads consistent with chromosomal sex combined with ambiguous, masculinized external genitalia. Recognized in many mammals, this condition results from fetal exposure to androgens that can be embryonic, maternal, or environmental in origin. Female pseudohermaphrodite black and brown bears ( Ursus americanus and U. arctos ) from Alberta, Canada, and polar bears ( U. maritimus ) from Svalbard, Norway, have been identified. Recent population surveys in Nunavut, Canada, led to the discovery of 11 additional female pseudohermaphrodite polar bears. Each bear was screened for the presence of sex-determining region- Y ( Sry ) and amelogenin-7 ( AMELY ) genes as indicators of Y-chromosome DNA. One bear possessed both genes, implying that trisomy or a chromosomal rearrangement may account for her virilized phenotype. Preliminary data suggested that Sry was also present in the other 10 bears; further testing disproved that result, revealed an important source of error when using polymerase chain reaction (PCR) to screen for the Sry gene, and led to the development of new amelogenin primers that provide superior sex information for bears. Ultimately, these extensive screens also supported the conclusion that 10 of 11 morphologically abnormal individuals may possess no genuine male-specific DNA. Therefore, nongenetic mechanisms such as maternal tumors, freemartinism, or endocrinological effects of environmental contaminants may also influence the development of the female pseudohermaphrodite phenotype in Nunavut polar bears. Text Nunavut Svalbard HighWire Press (Stanford University) Svalbard Nunavut Canada Norway |
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HighWire Press (Stanford University) |
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English |
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Feature Articles |
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Feature Articles Carmichael, Lindsey E. Krizan, Peter Blum, Susan Polischuk Strobeck, Curtis Genotyping of Pseudohermaphrodite Polar Bears in Nunavut and Advances in DNA Sexing Techniques |
topic_facet |
Feature Articles |
description |
Female pseudohermaphroditism is characterized by gonads consistent with chromosomal sex combined with ambiguous, masculinized external genitalia. Recognized in many mammals, this condition results from fetal exposure to androgens that can be embryonic, maternal, or environmental in origin. Female pseudohermaphrodite black and brown bears ( Ursus americanus and U. arctos ) from Alberta, Canada, and polar bears ( U. maritimus ) from Svalbard, Norway, have been identified. Recent population surveys in Nunavut, Canada, led to the discovery of 11 additional female pseudohermaphrodite polar bears. Each bear was screened for the presence of sex-determining region- Y ( Sry ) and amelogenin-7 ( AMELY ) genes as indicators of Y-chromosome DNA. One bear possessed both genes, implying that trisomy or a chromosomal rearrangement may account for her virilized phenotype. Preliminary data suggested that Sry was also present in the other 10 bears; further testing disproved that result, revealed an important source of error when using polymerase chain reaction (PCR) to screen for the Sry gene, and led to the development of new amelogenin primers that provide superior sex information for bears. Ultimately, these extensive screens also supported the conclusion that 10 of 11 morphologically abnormal individuals may possess no genuine male-specific DNA. Therefore, nongenetic mechanisms such as maternal tumors, freemartinism, or endocrinological effects of environmental contaminants may also influence the development of the female pseudohermaphrodite phenotype in Nunavut polar bears. |
format |
Text |
author |
Carmichael, Lindsey E. Krizan, Peter Blum, Susan Polischuk Strobeck, Curtis |
author_facet |
Carmichael, Lindsey E. Krizan, Peter Blum, Susan Polischuk Strobeck, Curtis |
author_sort |
Carmichael, Lindsey E. |
title |
Genotyping of Pseudohermaphrodite Polar Bears in Nunavut and Advances in DNA Sexing Techniques |
title_short |
Genotyping of Pseudohermaphrodite Polar Bears in Nunavut and Advances in DNA Sexing Techniques |
title_full |
Genotyping of Pseudohermaphrodite Polar Bears in Nunavut and Advances in DNA Sexing Techniques |
title_fullStr |
Genotyping of Pseudohermaphrodite Polar Bears in Nunavut and Advances in DNA Sexing Techniques |
title_full_unstemmed |
Genotyping of Pseudohermaphrodite Polar Bears in Nunavut and Advances in DNA Sexing Techniques |
title_sort |
genotyping of pseudohermaphrodite polar bears in nunavut and advances in dna sexing techniques |
publisher |
Oxford University Press |
publishDate |
2005 |
url |
http://jmammal.oxfordjournals.org/cgi/content/short/86/1/160 https://doi.org/10.1644/1545-1542(2005)086<0160:GOPPBI>2.0.CO;2 |
geographic |
Svalbard Nunavut Canada Norway |
geographic_facet |
Svalbard Nunavut Canada Norway |
genre |
Nunavut Svalbard |
genre_facet |
Nunavut Svalbard |
op_relation |
http://jmammal.oxfordjournals.org/cgi/content/short/86/1/160 http://dx.doi.org/10.1644/1545-1542(2005)086<0160:GOPPBI>2.0.CO;2 |
op_rights |
Copyright (C) 2005, Oxford University Press |
op_doi |
https://doi.org/10.1644/1545-1542(2005)086<0160:GOPPBI>2.0.CO;2 |
_version_ |
1766153138315722752 |