Pathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System Exposure
Background Epidemiologic, clinical, and laboratory data suggest that H5N1 influenza viruses are transmitted through and predominantly affect the respiratory system of mammals. Some data suggest digestive system involvement. However, direct evidence of alimentary transmission and infection in mammals...
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fthighwire:oai:open-archive.highwire.org:jinfdis:199/5/717 2023-05-15T18:44:12+02:00 Pathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System Exposure Lipatov, Aleksandr S. Kwon, Yong Kuk Pantin-Jackwood, Mary J. Swayne, David E. 2009-03-01 00:00:00.0 text/html http://jid.oxfordjournals.org/cgi/content/short/199/5/717 https://doi.org/10.1086/596740 en eng Oxford University Press http://jid.oxfordjournals.org/cgi/content/short/199/5/717 http://dx.doi.org/10.1086/596740 Copyright (C) 2009, Infectious Diseases Society of America Major Article TEXT 2009 fthighwire https://doi.org/10.1086/596740 2013-05-27T14:48:55Z Background Epidemiologic, clinical, and laboratory data suggest that H5N1 influenza viruses are transmitted through and predominantly affect the respiratory system of mammals. Some data suggest digestive system involvement. However, direct evidence of alimentary transmission and infection in mammals is lacking Methods Infection with and pathogenesis of 4 H5N1 viruses were assessed in mice and ferrets inoculated intranasally or intragastrically with virus in liquid. In addition, ferrets were fed infected raw chicken meat or minced meat administered into the stomach by gavage with a tube Results Only one virus, A/Whooper swan/Mongolia/244/05, was able to infect mice after intragastric inoculation in liquid, whereas no evidence of infection was observed in ferrets after intragastric inoculation. Consumption of infected meat by ferrets resulted in respiratory system infection only (due to A/Muscovy duck/Vietnam/209/05 and A/Whooper swan/Mongolia/244/05 viruses) or in both severe respiratory and systemic infection with predominant involvement of the liver, pancreas, and large and small intestine (due to A/Vietnam/1203/04 virus). Direct intragastric exposure to infected meat (A/Vietnam/1203/04 virus) resulted in lethal systemic disease mainly affecting the intestine, liver, and pancreas but not involving the lungs Conclusions Our results demonstrated that exposure of the digestive system to H5N1 influenza viruses could initiate infection either through the tonsil, with spread to respiratory tissues, or through intestinal infection, with spread to the liver and pancreas Text Whooper Swan HighWire Press (Stanford University) Journal of Infectious Diseases 199 5 717 725 |
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Major Article Lipatov, Aleksandr S. Kwon, Yong Kuk Pantin-Jackwood, Mary J. Swayne, David E. Pathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System Exposure |
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Major Article |
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Background Epidemiologic, clinical, and laboratory data suggest that H5N1 influenza viruses are transmitted through and predominantly affect the respiratory system of mammals. Some data suggest digestive system involvement. However, direct evidence of alimentary transmission and infection in mammals is lacking Methods Infection with and pathogenesis of 4 H5N1 viruses were assessed in mice and ferrets inoculated intranasally or intragastrically with virus in liquid. In addition, ferrets were fed infected raw chicken meat or minced meat administered into the stomach by gavage with a tube Results Only one virus, A/Whooper swan/Mongolia/244/05, was able to infect mice after intragastric inoculation in liquid, whereas no evidence of infection was observed in ferrets after intragastric inoculation. Consumption of infected meat by ferrets resulted in respiratory system infection only (due to A/Muscovy duck/Vietnam/209/05 and A/Whooper swan/Mongolia/244/05 viruses) or in both severe respiratory and systemic infection with predominant involvement of the liver, pancreas, and large and small intestine (due to A/Vietnam/1203/04 virus). Direct intragastric exposure to infected meat (A/Vietnam/1203/04 virus) resulted in lethal systemic disease mainly affecting the intestine, liver, and pancreas but not involving the lungs Conclusions Our results demonstrated that exposure of the digestive system to H5N1 influenza viruses could initiate infection either through the tonsil, with spread to respiratory tissues, or through intestinal infection, with spread to the liver and pancreas |
format |
Text |
author |
Lipatov, Aleksandr S. Kwon, Yong Kuk Pantin-Jackwood, Mary J. Swayne, David E. |
author_facet |
Lipatov, Aleksandr S. Kwon, Yong Kuk Pantin-Jackwood, Mary J. Swayne, David E. |
author_sort |
Lipatov, Aleksandr S. |
title |
Pathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System Exposure |
title_short |
Pathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System Exposure |
title_full |
Pathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System Exposure |
title_fullStr |
Pathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System Exposure |
title_full_unstemmed |
Pathogenesis of H5N1 Influenza Virus Infections in Mice and Ferret Models Differs According to Respiratory Tract or Digestive System Exposure |
title_sort |
pathogenesis of h5n1 influenza virus infections in mice and ferret models differs according to respiratory tract or digestive system exposure |
publisher |
Oxford University Press |
publishDate |
2009 |
url |
http://jid.oxfordjournals.org/cgi/content/short/199/5/717 https://doi.org/10.1086/596740 |
genre |
Whooper Swan |
genre_facet |
Whooper Swan |
op_relation |
http://jid.oxfordjournals.org/cgi/content/short/199/5/717 http://dx.doi.org/10.1086/596740 |
op_rights |
Copyright (C) 2009, Infectious Diseases Society of America |
op_doi |
https://doi.org/10.1086/596740 |
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Journal of Infectious Diseases |
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199 |
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5 |
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717 |
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725 |
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1766234788074618880 |