Severe Respiratory Syncytial Virus Disease in Alaska Native Children
Hospitalization rates for respiratory syncytial virus (RSV) infection range from 1 to 20/1000 infants. To determine the rate and severity of RSV infections requiring hospitalization for infants in the Yukon-Kuskokwim (YK) Delta of Alaska, a 3-year prospective surveillance study was conducted. The an...
Published in: | The Journal of Infectious Diseases |
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fthighwire:oai:open-archive.highwire.org:jinfdis:180/1/41 2023-05-15T17:05:39+02:00 Severe Respiratory Syncytial Virus Disease in Alaska Native Children Karron, Ruth A. Singleton, Rosalyn J. Bulkow, Lisa Parkinson, Alan Kruse, Donn DeSmet, Irma Indorf, Carol Petersen, Kenneth M. Leombruno, Donna Hurlburt, Debra Santosham, Mathuram Harrison, Lee H. for the RSV Alaska Study Group 1999-07-01 00:00:00.0 text/html http://jid.oxfordjournals.org/cgi/content/short/180/1/41 https://doi.org/10.1086/314841 en eng Oxford University Press http://jid.oxfordjournals.org/cgi/content/short/180/1/41 http://dx.doi.org/10.1086/314841 Copyright (C) 1999, Infectious Diseases Society of America Major Articles TEXT 1999 fthighwire https://doi.org/10.1086/314841 2013-05-27T02:00:19Z Hospitalization rates for respiratory syncytial virus (RSV) infection range from 1 to 20/1000 infants. To determine the rate and severity of RSV infections requiring hospitalization for infants in the Yukon-Kuskokwim (YK) Delta of Alaska, a 3-year prospective surveillance study was conducted. The annual rate of RSV hospitalization for YK Delta infants <1 year of age was 53–249/1000. RSV infection was the most frequent cause of infant hospitalization. RSV disease severity did not differ among non—high-risk infants in the YK Delta and at Johns Hopkins Hospital (JHH). On average, 1/125 infants born in the YK Delta required mechanical ventilation for RSV infection. During the peak season, ∼$1034/child <3 years of age was spent on RSV hospitalization in the YK Delta. In YK Delta infants ⩽6 months old, RSV micro-neutralizing antibody titers <1200 were associated with severe disease (odds, ratio = 6.2 P = .03). In the YK Delta and at JHH, newborns may be at greater risk for severe RSV illness than previously thought. Text Kuskokwim Alaska Yukon HighWire Press (Stanford University) Yukon The Journal of Infectious Diseases 180 1 41 49 |
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HighWire Press (Stanford University) |
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English |
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Major Articles |
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Major Articles Karron, Ruth A. Singleton, Rosalyn J. Bulkow, Lisa Parkinson, Alan Kruse, Donn DeSmet, Irma Indorf, Carol Petersen, Kenneth M. Leombruno, Donna Hurlburt, Debra Santosham, Mathuram Harrison, Lee H. for the RSV Alaska Study Group Severe Respiratory Syncytial Virus Disease in Alaska Native Children |
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Major Articles |
description |
Hospitalization rates for respiratory syncytial virus (RSV) infection range from 1 to 20/1000 infants. To determine the rate and severity of RSV infections requiring hospitalization for infants in the Yukon-Kuskokwim (YK) Delta of Alaska, a 3-year prospective surveillance study was conducted. The annual rate of RSV hospitalization for YK Delta infants <1 year of age was 53–249/1000. RSV infection was the most frequent cause of infant hospitalization. RSV disease severity did not differ among non—high-risk infants in the YK Delta and at Johns Hopkins Hospital (JHH). On average, 1/125 infants born in the YK Delta required mechanical ventilation for RSV infection. During the peak season, ∼$1034/child <3 years of age was spent on RSV hospitalization in the YK Delta. In YK Delta infants ⩽6 months old, RSV micro-neutralizing antibody titers <1200 were associated with severe disease (odds, ratio = 6.2 P = .03). In the YK Delta and at JHH, newborns may be at greater risk for severe RSV illness than previously thought. |
format |
Text |
author |
Karron, Ruth A. Singleton, Rosalyn J. Bulkow, Lisa Parkinson, Alan Kruse, Donn DeSmet, Irma Indorf, Carol Petersen, Kenneth M. Leombruno, Donna Hurlburt, Debra Santosham, Mathuram Harrison, Lee H. for the RSV Alaska Study Group |
author_facet |
Karron, Ruth A. Singleton, Rosalyn J. Bulkow, Lisa Parkinson, Alan Kruse, Donn DeSmet, Irma Indorf, Carol Petersen, Kenneth M. Leombruno, Donna Hurlburt, Debra Santosham, Mathuram Harrison, Lee H. for the RSV Alaska Study Group |
author_sort |
Karron, Ruth A. |
title |
Severe Respiratory Syncytial Virus Disease in Alaska Native Children |
title_short |
Severe Respiratory Syncytial Virus Disease in Alaska Native Children |
title_full |
Severe Respiratory Syncytial Virus Disease in Alaska Native Children |
title_fullStr |
Severe Respiratory Syncytial Virus Disease in Alaska Native Children |
title_full_unstemmed |
Severe Respiratory Syncytial Virus Disease in Alaska Native Children |
title_sort |
severe respiratory syncytial virus disease in alaska native children |
publisher |
Oxford University Press |
publishDate |
1999 |
url |
http://jid.oxfordjournals.org/cgi/content/short/180/1/41 https://doi.org/10.1086/314841 |
geographic |
Yukon |
geographic_facet |
Yukon |
genre |
Kuskokwim Alaska Yukon |
genre_facet |
Kuskokwim Alaska Yukon |
op_relation |
http://jid.oxfordjournals.org/cgi/content/short/180/1/41 http://dx.doi.org/10.1086/314841 |
op_rights |
Copyright (C) 1999, Infectious Diseases Society of America |
op_doi |
https://doi.org/10.1086/314841 |
container_title |
The Journal of Infectious Diseases |
container_volume |
180 |
container_issue |
1 |
container_start_page |
41 |
op_container_end_page |
49 |
_version_ |
1766060348784246784 |